54 results for “Reaction Department”, page 2 of 3
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Medical study · Medical research · 1987
The stimulatory effects of asbestos on NADPH-dependent lipid peroxidation in rat liver microsomes
…It is not inhibited by superoxide dismutase, catalase and mannitol, indicating that oxygen radicals are not involved in the reaction. It is also not inhibited by desferrioxamine, indicating that it is not due to a release…
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Medical study · Medical research · 2011
A₃ receptors are overexpressed in pleura from patients with mesothelioma and reduce cell growth via Akt/nuclear factor-κB pathway
…between adenosine and MM, the presence and functionality of ARs were explored in human healthy mesothelial cells (HMC) and in malignant mesothelioma cells (MMC). ARs were analyzed by using reverse transcriptase-polymerase chain reaction, Western blotting…
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Medical study · Medical research · 2005
Potential toxicity of nonregulated asbestiform minerals: balangeroite from the western Alps. Part 3: Depletion of antioxidant defenses
…crocidolite incubation. This effect was not related to any increased content of oxidized glutathione, or to any enhanced efflux of glutathione, suggesting that balangeroite fibers, like crocidolite, might favor the reaction of GSH with other molecules.
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Medical study · Medical research · 1984
Asbestos catalyzes hydroxyl and superoxide radical generation from hydrogen peroxide
…hydroxyl radicals from a normal byproduct of tissue metabolism, hydrogen peroxide. The iron chelator desferroxamine inhibits this reaction, indicating a major role for iron in the catalytic process, and suggesting a possible mechanism by which asbestos…
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Medical study · Medical research · 1998
Modulation of mitochondrial gene expression in pulmonary epithelial cells exposed to oxidants
…RNA was extracted, reverse transcribed, and amplified by polymerase chain reaction with degenerate primers to visualize alterations in gene expression. The seven clones obtained were sequenced and encoded the mitochondrial genes, NADH dehydrogenase subunits ND5 and…
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Medical study · Medical research · 2003
Oxalate deposition on asbestos bodies
…vitro generated approximately 42 nmol of oxalate in 24 hours. Oxalate generation was diminished significantly by the inclusion of either deferoxamine or dimethylthiourea in the reaction mixture. Incubation of asbestos bodies and uncoated fibers isolated from…
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Medical study · Medical research · 2000
Crocidolite induces cell transformation and p53 gene mutation in BALB/c-3T3 cells
…foci and subjected to mutational analysis. Eleven exons of the p53 gene from eight transformed cell lines were analyzed for alterations using polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP). Alterations were found in seven…
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Medical study · Medical research · 1994
Asbestos fibers and interferon-gamma up-regulate nitric oxide production in rat alveolar macrophages
…in macrophage conditioned medium, was assayed by the Griess reaction. Production of NO2- by AM was significantly increased by both chrysotile (P < 0.01) and crocidolite (P < 0.05) asbestos fibers (10 micrograms/ml…
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Medical study · Medical research · 1996
A study of the synergistic interaction of asbestos fibers with cigarette tar extracts for the generation of hydroxyl radicals in aqueous buffer solution
…This enhancement progressed with time, probably due to the reaction of the extracted iron with the slow released hydrogen peroxide from tar extracts. It was observed a fivefold increase in the ESR signal (for crocidolite and…
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Medical study · Medical research · 2023
Microbe-Mineral Interactions between Asbestos and Thermophilic Chemolithoautotrophic Anaerobes
…structure of the asbestos mineral fibers. Further constraints on the relationships between elemental release rates, amount of starting asbestos, reaction volumes, and incubation times will be required to better compare asbestos dissolution treatments studied to date.
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Medical study · Medical research · 2018
Fibrous nanocellulose, crystalline nanocellulose, carbon nanotubes, and crocidolite asbestos elicit disparate immune responses upon pharyngeal aspiration in mice
…BAL cells. The results revealed that pulmonary exposure to fibrous materials led to discrete local immune cell polarization patterns with a TH2-like response caused by ASB and TH1-like immune reaction to NCF, while CNT…
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Medical study · Medical research · 2000
In vitro cleavage by asbestos fibers of the fifth component of human complement through free-radical generation and kallikrein activation
…role in inflammatory reactions characteristic of asbestosis through mechanisms involving iron ions, hydroxyl radicals, and oxidized C5-ike fragments. The ferrous ions present at the asbestos fiber surface trigger this activation and catalyze, via Fenton reaction…
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Medical study · Medical research · 2009
Absence of carcinogenic response to multiwall carbon nanotubes in a 2-year bioassay in the peritoneal cavity of the rat
…fibers have been suggested. We previously reported that multiwall carbon nanotubes (MWCNT) induced lung inflammation, granulomas and fibrotic reactions. The same MWCNT also caused mutations in epithelial cells in vitro and in vivo. These inflammatory and…
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Medical study · Medical research · 2007
Calcitonin gene-related peptide (CGRP) as hazard marker for lung injury induced by dusts
…fibrosis were present in those exposed to SiCW and PT-1. The expression of CGRP in rat lung was observed by reverse-transcription polymerase chain reaction (RT-PCR) and enzyme immunometric assay (EIA). In RT-PCR…
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Medical study · Medical research · 1997
Pleural macrophage recruitment and activation in asbestos-induced pleural injury
…by scanning electron microscopy. Pleural macrophage supernatants were assayed for production of nitric oxide (NO) (by the Griess reaction) and tumor necrosis factor alpha (TNF-alpha) (by an enzyme-linked immunosorbent assay method). Significantly greater amounts…
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Medical study · Medical research · 1997
Short-term inhalation and in vitro tests as predictors of fiber pathogenicity
…and SiC. However, measurements of BrdU uptake into lung cells showed that amosite and SiC produced a greater reaction than code 100/475, which itself caused no more proliferation than that seen in untreated lungs. These…
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Court case · Texas Court of Appeals · December 19, 2019 · in the opinion
Union Carbide Corporation v. Torres (2019)
…the inhalation of asbestos fibers and the penetration of the fibers through the air sac of the lung. He explained that the body's inflammatory reaction to the fibers causes genetic damage. As the damage accumulates…
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Court case · Louisiana Supreme Court · April 13, 1999 · in the opinion
Ruckstuhl v. Owens Corning Fiberglas Corp. (1999)
…3201, listed specific activities by a defendant which would subject it to the personal jurisdiction of this state.\[2\] In reaction to [\885] the decision of the United States Supreme Court in World-Wide Volkswagen Corp…
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Medical study · Medical research · 1988
Cooperative stimulation by sulfite and crocidolite asbestos fibres of enzyme catalyzed production of reactive oxygen species
…plus the chemical EDTA produced 2160 pmol of ethylene, against 683 pmol for EDTA alone and 29 pmol for crocidolite alone. The authors stated that these model reactions are no proof of reactions in the body.
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Medical study · Medical research · 2001
Localised spontaneous regression in mesothelioma -- possible immunological mechanism
…lobe. Blood samples from her last 11 months showed antibodies against mesothelioma. Two of these reactions faded and one stayed stable. The authors judged this strong circumstantial evidence linking the immune cells to the regression. They…