558 results for “Reaction Department”, page 22 of 28
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Medical study · Medical research · 1987
Immunocytological staining reactions of anti-carcinoembryonic antigen, Ca, and anti-human milk fat globule monoclonal antibodies on benign and malignant exfoliated mesothelial cells
This laboratory study tested whether three antibody stains could help tell mesothelioma apart from lung cancer and from benign conditions, using cells shed into body-cavity fluid (pleural or peritoneal effusions). The stains detected…
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Medical study · Medical research · 2004
Varying risk comparison elements: effects on public reactions
…found format variations swamped in their effect by concern about asbestos, with the absence of a narrative and the parental role being the only attributes that increased negative risk reactions. Multiple regression analyses found that multidimensionality…
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Medical study · Medical research · 1993
Pathogenesis of mesothelial reactions to asbestos fibers. Monocyte recruitment and macrophage activation
Exposure to asbestos fibers leads to a variety of mesothelial reactions: pleural effusions, fibrotic pleural plaques, and malignant mesotheliomas. An animal model was developed to reproduce these lesions in C57B1/6 mice using weekly intraperitoneal injections…
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Medical study · Medical research · 2018
Nanomaterial exposure and sterile inflammatory reactions
…and that of the general population. Moreover, the possible pathological consequences of nanomaterial-induced sterile inflammatory reactions need to be clarified in order to define suitable preventive measures to protect the health of chronically exposed subjects.
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Medical study · Medical research · 2016
Single-dose dexamethasone for the prevention of pemetrexed associated cutaneous adverse reactions
…non-small-cell-lung-cancer. Cutaneous adverse reactions are common side effects of pemetrexed for which the manufacturer recommends 3-day premedication with dexamethasone 4 mg by mouth twice daily-(the day before, the day of…
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Medical study · Medical research · 1954
Experimental Studies In Metal Carcinogenesis: Vi. Tissue Reactions In Rats And Rabbits After Parenteral Introduction Of Suspensions Of Arsenic, Beryllium, Or Asbestos In Lanolin
…pleural cavity had no tumors in the lungs, pleurae or chest wall, and the nasal sinus rats showed no specific reactions to the asbestos. Across all 250 rats, the sarcoma rate at injection sites was 0…
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Medical study · Medical research · 1985
Characterization of the bronchoalveolar cellular response in experimental asbestosis. Different reactions depending on the fibrogenic potential
This was an animal experiment in male Wistar rats. Each rat received a single injection into the windpipe of saline (control), 5 mg of UICC chrysotile B asbestos, or 5 mg of very short 4T30 chrysotile fibers. Lung washings (bronchoalveolar lavage)…
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Medical study · Medical research · 2002
Stability and inoculation of risk comparisons' effects under conflict: replicating and extending the "asbestos jury" study by Slovic et al
This experiment studied reactions to risk comparisons, not asbestos disease. The author replicated and extended a 1990 experiment by Slovic and colleagues. Participants played jurors in a hypothetical school board lawsuit against an asbestos installer. Students…
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Medical study · Medical research · 2016
Immunogenicity of therapeutic recombinant immunotoxins
This article was a review by National Cancer Institute researchers of immune reactions to recombinant immunotoxins, experimental cancer drugs that join an antibody fragment to part of a Pseudomonas bacterial toxin. It did not study asbestos…
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Medical study · Medical research · 2016
New Markers for Separating Benign From Malignant Mesothelial Proliferations: Are We There Yet?
This was a literature review of laboratory tests for telling malignant mesothelioma from benign mesothelial reactions. The authors wrote that five older stains (GLUT-1, p53, IMP-3, epithelial membrane antigen and desmin) worked only in…
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Medical study · Medical research · 2013
Asbestos-like pathogenicity of long carbon nanotubes alleviated by chemical functionalization
This was a short-term experiment in mice testing whether chemically modifying long multi-walled carbon nanotubes changes the asbestos-like reactions they cause. The authors took long, unmodified nanotubes previously used by another research group…
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Medical study · Medical research · 1998
Contribution of reactive oxygen and nitrogen species to particulate-induced lung injury
…reactive oxygen species (superoxide anion, hydrogen peroxide, hydroxyl radical formed through Fenton/Haber-Weiss reactions) and of reactive nitrogen species, in which nitric oxide reacts with superoxide to form peroxynitrite, an oxidant that nitrates tyrosine residues…
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Medical study · Medical research · 1955
Medicolegal Aspects Of Cancer
…timing to fit the tumor's growth rate. These changes could be presumed without direct evidence if an uninterrupted chain of tissue reactions led from injury to cancer. The author accepted that injury might speed an…
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Medical study · Medical research · 2018
Response to "An innovative mesothelioma treatment based on mir-16 mimic loaded EGFR targeted minicells (TargomiRs)"
…minicells by tumours. They agreed that pre- and post-treatment biopsies will be key. They could not exclude immune reactions to the minicells' LPS-containing surface as an explanation for anti-tumour activity. However, they noted…
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Medical study · Medical research · 2016
Drug fever after cancer chemotherapy is most commonly observed on posttreatment days 3 and 4
…31 %, p < 0.001). The febrile episodes that occurred on posttreatment days 3 and 4 were considered to represent adverse drug reactions after cancer chemotherapy. Physicians should be aware of this feature of chemotherapy-associated…
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Medical study · Medical research · 2022
Preliminary validation of a brief PROM assessing psychological distress in patients with malignant mesothelioma: The mesothelioma psychological distress tool-Patients
…interval factor loading standardized effect size fell outside of the region of practical equivalence. Bayesian exploratory factor analysis showed a two-factor structure: (1) Trauma-related reactions (TR, 13 items) and (2) Claim for justice (CJ…
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Medical study · Medical research · 1954
Effects Of Dusts And Fumes Upon Man
…such as silicosis and asbestosis, toxic dusts such as lead, metal-fume fever, and allergic reactions. On asbestosis, they described a diffuse fibrosis on X-ray without the nodules typical of silicosis. They also described asbestos…
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Medical study · Medical research · 2019
Treatment status and safety of crizotinib in 2028 Japanese patients with ALK-positive NSCLC in clinical settings
…included 2028 Japanese patients, and more than half of the patients (56.4%) were nonsmokers. The incidence of adverse drug reactions (ADRs) was 91.6%, and common ADRs (incidence ≥15%) were nausea (32.2%), diarrhea (24…
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Medical study · Medical research · 2019
Phase I study of YS110, a recombinant humanized monoclonal antibody to CD26, in Japanese patients with advanced malignant pleural mesothelioma
…toxicity. Corticosteroid, antihistamine, and acetaminophen administration before each infusion was adopted to limit infusion-related reactions (IRRs). Nine Japanese patients (seven men and two women, mean age of 62.2 years), three in each dosing cohort…
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Medical study · Medical research · 2020
A Phase II Study of Pazopanib in Patients with Malignant Pleural Mesothelioma: NCCTG N0623 (Alliance)
…had no earlier chemotherapy and 15 had received a pemetrexed-containing regimen. The main goal was the share alive and progression-free at 6 months without having stopped treatment for adverse reactions, refusal or other therapy…