558 results for “Reaction Department”, page 25 of 28
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Medical study · Medical research · 1997
Thoracic complications in patients undergoing intraperitoneal heated chemotherapy with mitomycin following cytoreductive surgery
The purpose of this study was to determine the incidence and severity of thoracic reactions in patients undergoing intraperitoneal heated chemotherapy (IPHC). Forty-two patients who had intraperitoneal disseminated malignancies were treated with cytoreductive surgery (CS…
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Medical study · Medical research · 2017
Absence of in vivo mutagenicity of multi-walled carbon nanotubes in single intratracheal instillation study using F344 gpt delta rats
…particles of micrometer length, such as carbon nanotubes, which have same dimensions as asbestos, are carcinogenic. Carcinogenicity of nanomaterials is strongly related to inflammatory reactions; however, the genotoxicity mechanism(s) is unclear. Indeed, inconsistent results on…
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Medical study · Medical research · 2017
The Lost City Hydrothermal Field: A Spectroscopic and Astrobiological Analogue for Nili Fossae, Mars
…temperature serpentinization is a critical process with respect to Earth's habitability and the Solar System. Exothermic serpentinization reactions commonly produce hydrogen as a direct by-product and typically produce short-chained organic compounds indirectly. Here…
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Medical study · Medical research · 2016
Pemetrexed-induced scleroderma-like conditions in the lower legs of a patient with non-small cell lung carcinoma
Pemetrexed, which is used for the treatment of non-small cell lung carcinoma and malignant mesothelioma, induces cutaneous adverse reactions in approximately 20% of patients. There are also reports of the induction of fibrosing disorders. We…
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Medical study · Medical research · 2019
Carbonic anhydrase 9 confers resistance to ferroptosis/apoptosis in malignant mesothelioma under hypoxia
…and acidity provide microenvironment for selection under evolutionary pressure and proliferation in cancer cells. Carbonic anhydrases (CAs) are a superfamily of metalloenzymes present in all life kingdoms, equilibrating the reactions among CO2, bicarbonate and H+. CA9…
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Medical study · Medical research · 1991
Radiological features of asbestos-related visceral pleural changes
…Generally, visceral pleural reactions follow the mesothelial cells response to various injurious substances, including asbestos, and even saline. The changes are nonspecific. They may occur subsequent to pleural reactions associated with many conditions, which include tuberculosis…
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Medical study · Medical research · 2013
Pemetrexed-induced eyelid edema in lung cancer
…small cell lung cancer. Although pemetrexed is a safe drug, some adverse effects such as myelosupression and cutaneous reactions are observed. Pemetrexed-induced eyelid edema is a rare side effect of pemetrexed treatment, and until this…
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Medical study · Medical research · 1983
Failure of macrophage activation to induce pulmonary fibrosis in asbestos-exposed guinea-pigs
…a diffuse pulmonary mononuclear-cell infiltration of the interstitium and air space. The severity of the reactions to the various insults was dependent on the treatment given. Although there was no histological evidence of increased collagen…
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Medical study · Medical research · 2013
Cytotoxicity induced by exposure to natural and synthetic tremolite asbestos: an in vitro pilot study
…the etiology of the pathological effects of asbestos, cellular reactions to natural and synthetic asbestos fibers were compared using a lung alveolar cancer cell line (A549 epithelial cells), considered the first target of inhaled micro-environmental…
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Medical study · Medical research · 1997
Pleural disease during treatment with bromocriptine in patients previously exposed to asbestos
Bromocriptine, which is used in the treatment of Parkinson's disease, can cause adverse pleuropulmonary reactions. Exposure to asbestos can result in similar lesions. Fifteen patients with former exposure to asbestos, who developed pleural fibrosis after…
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Medical study · Medical research · 2011
Potent anti-tumor killing activity of the multifunctional Treg cell line HOZOT against human tumors with diverse origins
The T cell line HOZOT has a unique FOXP3+CD4+ CD8+CD25+ phenotype, exhibits suppressive activity in allogeneic mixed lymphocyte reactions (MLR), and produces IL-10, defining HOZOT as regulatory T cells (Tregs). Interestingly, in addition…
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Medical study · Medical research · 2013
Mantle wedge infiltrated with saline fluids from dehydration and decarbonation of subducting slab
…derived fluids play an important role in heat and material transfer in subduction zones. Dehydration and decarbonation reactions of minerals in the subducting slab have been investigated using phase equilibria and modeling of fluid flow. Nevertheless…
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Medical study · Medical research · 2003
beta1-integrin mediates asbestos-induced phosphorylation of AKT and ERK1/2 in a rat pleural mesothelial cell line
…In studies here, we examined signal transduction events associated with integrin-directed cell reactions triggered by crocidolite asbestos in the pleural mesothelial cell line 4/4 RM-4. Crocidolite fibres induced a significant time- and dose…
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Medical study · Medical research · 2015
A Single Aspiration of Rod-like Carbon Nanotubes Induces Asbestos-like Pulmonary Inflammation Mediated in Part by the IL-1 Receptor
…product development and potential risks on health. We investigated the difference of two different CNT and asbestos in inducing proinflammatory reactions in C57BL/6 mice after single pharyngeal aspiration exposure. We used long tangled and long…
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Medical study · Medical research · 1991
Selective differences in macrophage populations and monokine production in resolving pulmonary granuloma and fibrosis
Alveolar macrophages (AM) and their production of interleukin-1-like activity (IL-1) and macrophage-derived growth factor for fibroblasts (MDGF) were examined during chronic inflammatory reactions leading to either granuloma formation or fibrosis. Groups of…
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Medical study · Medical research · 1985
Asbestos-induced decomposition of hydrogen peroxide
…radicals in this process was delineated employing the OH radical scavenger dimethyl sulfoxide (DMSO). A mechanism involving the Fenton and Haber-Weiss reactions as the pathway for the H2O2 decomposition and OH radical production is postulated.
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Medical study · Medical research · 2020
The Current Understanding Of Asbestos-Induced Epigenetic Changes Associated With Lung Cancer
…to epigenetic changes and lung cancer is incomplete. It has been shown that oxidoreduction reactions on fibre surfaces generate reactive oxygen species (ROS) which in turn damage DNA, leading to genetic and epigenetic alterations that reduce…
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Medical study · Medical research · 2018
Persistent Pleural Lesions and Inflammation by Pulmonary Exposure of Multiwalled Carbon Nanotubes
…spraying, the rats were sacrificed for histological examination of the lung and chest wall; pleural cavity lavage was also collected at sacrifice for observation of pleural inflammatory reactions. The results indicated that intratracheally sprayed MWCNTs, like…
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Medical study · Medical research · 2019
The Effect of pH and Biogenic Ligands on the Weathering of Chrysotile Asbestos: The Pivotal Role of Tetrahedral Fe in Dissolution Kinetics and Radical Formation
…octahedra (Fe[6]), and FeIII substitutes Si tetrahedra (Fe[4]). Fe on fiber surfaces can generate hydroxyl radicals (HO. ) in Fenton reactions, which damage biomolecules. To better understand chrysotile weathering in soils, net Mg and Si…
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Medical study · Medical research · 2019
Iron addiction with ferroptosis-resistance in asbestos-induced mesothelial carcinogenesis: Toward the era of mesothelioma prevention
…caused by modern industrial development. The major pathogenic mechanisms include oxidative stress either via catalytic reactions against the asbestos surface or frustrated phagocytosis of macrophages, and specific adsorption of hemoglobin and histones by asbestos fibers in…