1,074 results for “Reaction Department”, page 26 of 54
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Medical study · Medical research · 2009
Beta-carotene metabolites enhance inflammation-induced oxidative DNA damage in lung epithelial cells
…Moreover, BC and BCM were able to increase (.)OH formation from H(2)O(2) in the Fenton reaction (determined by electron spin resonance spectroscopy). Addition of Vit A and RA to lung epithelial cells that…
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Medical study · Medical research · 2011
MicroRNAs dysregulation in human malignant pleural mesothelioma
…with microarray approach. These results were confirmed by real-time quantitative reverse-transcriptase polymerase chain reaction and Western blotting. A comparative analysis of miRNA expression in MPM and HMCs was carried out. Microarray profiling showed different…
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Medical study · Medical research · 2005
Potential toxicity of nonregulated asbestiform minerals: balangeroite from the western Alps. Part 3: Depletion of antioxidant defenses
…crocidolite incubation. This effect was not related to any increased content of oxidized glutathione, or to any enhanced efflux of glutathione, suggesting that balangeroite fibers, like crocidolite, might favor the reaction of GSH with other molecules.
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Medical study · Medical research · 2014
Epidermal growth factor receptor mutations in 510 Finnish non--small-cell lung cancer patients
…embedded, formalin-fixed tumor material using the following real-time polymerase chain reaction-based kits: Therascreen EGFR PCR Kit and cobas EGFR Mutation Test. EGFR mutation frequency was 11.4% and all positive cases were adenocarcinomas…
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Medical study · Medical research · 1978
The adsorption of biological macromolecules by mineral dusts
…strong” adsorption reactions were noted with serum proteins, the latter being considered as the most specific for each mineral and perhaps the most important physiologically. The implications of the observed adsorption phenomena to the reaction between…
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Medical study · Medical research · 1985
An assessment of the fibrogenic potential of very short 4T30 chrysotile by intratracheal instillation in rats
…structure, and surface charge, the lung tissue reaction differed considerably. Lungs of animals exposed to UICC chrysotile B showed significant pathological alterations as early as 7 days following treatment. The lesions were localized in and around…
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Medical study · Medical research · 2014
Well-differentiated papillary mesothelioma of the tunica vaginalis: a case study and review of the literature
…structures with focal coagulative necrosis were present. In addition to immunohistochemistry, simian virus 40 DNA was also tested by polymerase chain reaction. This report presents one case of this rare entity, its clinical and macroscopic features…
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Medical study · Medical research · 2000
Presence and expression of the simian virus-40 genome in human giant cell tumors of bone
…tumors (GCTs), moderately benign bone tumors that in some cases can progress to a malignant phenotype. Polymerase chain reaction (PCR), using primers that amplify the RB1 pocket binding domain and the intron of Tag, was used…
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Medical study · Medical research · 2011
EphrinA1 inhibits malignant mesothelioma tumor growth via let-7 microRNA-mediated repression of the RAS oncogene
…repression of RAS proto-oncogene and the attenuation of MM tumor growth. The expression of miRNAs was determined by reverse transcription-quantitative polymerase chain reaction and in situ hybridization. RAS expression was determined by q-PCR…
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Medical study · Medical research · 2002
Despite some expression of folate receptor alpha in human mesothelioma cells, internalization of methotrexate is predominantly carrier mediated
…expression analysis for the carrier and receptor gene was done by using real-time reverse transcriptase-polymerase chain reaction in the above-mentioned cell lines and mesothelioma tumor tissues obtained from patients. Internalization of tritiated methotrexate…
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Medical study · Medical research · 2013
Metabolic response to pegylated arginine deiminase in mesothelioma with promoter methylation of argininosuccinate synthetase
…1 (ASS1). Immunohistochemistry showed his tumor was ASS1-deficient, and methylation-specific polymerase chain reaction confirmed ASS1 promoter methylation. He was randomly assigned to 320 IU/m2/wk of ADI-PEG20 by intramuscular injection. After 3…
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Medical study · Medical research · 2001
K-ras and rho A mutations in malignant pleural effusion
…and have been proposed to be a prognostic factor. The K-ras mutation in codon 12 is detectable even in cell-free fluids by using the enriched polymerase chain reaction (PCR) technique. On the other hand…
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Medical study · Medical research · 2012
Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells
…cells from 6TG and 5FU, consistent with the idea that adenine produced from the MTAP reaction competes with 6TG and 5FU for a rate limiting pool of phosphoribosyl-1-pyrophosphate (PRPP), which is required for the…
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Medical study · Medical research · 2013
No detection of simian virus 40 in malignant mesothelioma in Korea
…We analyzed 62 cases of available paraffin-blocks enrolled through the Korean Malignant Mesothelioma Surveillance System and performed immunohistochemistry for SV40 protein and real-time polymerase chain reaction (PCR) for SV40 DNA. Of 62 total cases…
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Medical study · Medical research · 1994
Polyclonal human T-cell activation by silicate in vitro
…to silicate dust. T-cell receptor (TcR) V beta gene analysis on CD4- CD8- double-negative alpha beta T cells from scleroderma patients, using polymerase chain reaction (PCR), showed that certain V beta genes, V beta…
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Medical study · Medical research · 2001
Atypical carcinoid presenting as mesothelioma
…of the lung. In one case, pleural spread of tumor was seen while in the other an extensive fibrotic pleural reaction existed. To our knowledge these cases represent the first examples of atypical carcinoid causing pseudomesothelioma.
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Medical study · Medical research · 2014
Correlation between TS, MTHFR, and ERCC1 gene polymorphisms and the efficacy of platinum in combination with pemetrexed first-line chemotherapy in mesothelioma patients
…combination with pemetrexed or pemetrexed monotherapy were enrolled. Genomic DNA was isolated from peripheral blood. Using polymerase chain reaction and high resolution melt methods, the variable number of tandem repeat, the G>C single nucleotide polymorphism (SNP…
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Medical study · Medical research · 2005
The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer
…genes that are regulated by mineral dusts. Using a differential display reverse transcription polymerase chain reaction technique and mRNAs of alveolar macrophages from both normal individuals and coal miners, we identified a novel mineral dust-induced…
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Medical study · Medical research · 1984
Asbestos catalyzes hydroxyl and superoxide radical generation from hydrogen peroxide
…hydroxyl radicals from a normal byproduct of tissue metabolism, hydrogen peroxide. The iron chelator desferroxamine inhibits this reaction, indicating a major role for iron in the catalytic process, and suggesting a possible mechanism by which asbestos…
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Medical study · Medical research · 1987
Congenital polycystic tumor of the atrioventricular node (endodermal heterotopia, mesothelioma): a histogenetic appraisal with evidence for its endodermal origin
…similar distribution to that of the argyrophil cells. A positive reaction of different distribution from that of the argyrophil cells was noted in a varying number of tubule-lining cells for carcinoembryonic antigen, epithelial membrane antigen…