558 results for “Reaction Department”, page 26 of 28
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Medical study · Medical research · 2022
In vivo genotoxicity assessment of a multiwalled carbon nanotube in a mouse ex vivo culture
… however, only MWNT-7 is classified into Group 2B by The International Agency for Research on Cancer. MWNT-7's carcinogenicity is strongly related to inflammatory reactions. On the other hand, inconsistent results on MWNT-7…
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Medical study · Medical research · 2003
Cell signaling and transcription factor activation by asbestos in lung injury and disease
…through receptor-mediated events or integrins. Alternatively, they may be stimulated by oxidants generated both during phagocytosis of minerals and/or by redox reactions on the mineral surface. Once initiated, these pathways can lead to promotion…
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Medical study · Medical research · 1973
Acute and chronic effects of intraperitoneal injection of two types of asbestos in rats with a study of the histopathogenesis and ultrastructure of resulting mesotheliomas
…approximately 40% mortality, within 8 days after the injection associated with acute peritonities. Tissue reactions to these two types of asbestos were significantly different. Crocidolite fibers were easily seen by light microscopy, in the tissue sections…
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Medical study · Medical research · 2000
Scanning electron microscopical investigations of broncho-alveolar casts after intratracheal asbestos fibre instillation
…the pleural space could not be explained satisfactorily. Histomorphological examinations showed that intratracheal instillation of asbestos fibres leads to parabronchial and intraalveolar granulomatous tissue reactions and bronchial epithelial regenerations. For further elucidation of the pathogenesis of…
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Medical study · Medical research · 2012
Surface reactivity and cell responses to chrysotile asbestos nanofibers
…Alps. Electron microscopy, X-ray diffraction, and fluorescence spectroscopy revealed that the procedure does not affect mineralogical and chemical composition. Surface reactions related to oxidative stress, free radical generation, bioavailability of iron, and antioxidant depletion, revealed…
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Medical study · Medical research · 2014
Erionite induces production of autoantibodies and IL-17 in C57BL/6 mice
…is little known about its effects on the immune system. We performed this study to determine whether erionite evokes autoimmune reactions in mice. Bone marrow derived macrophages (BMDM) were used to measure toxicity induced by erionite…
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Medical study · Medical research · 2003
Long and short fiber amosite asbestos alters at a different extent the redox metabolism in human lung epithelial cells
…cells A549, long amosite fibers, more effectively than the short ones, initiate free radical reactions, inhibit the glucose 6-phosphate dehydrogenase activity and the pentose phosphate pathway, decrease the intracellular level of reduced glutathione, and increase…
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Medical study · Medical research · 1989
Tobacco-borne siderophoric activity
…Indeed, elements in tobacco smoke and asbestos synergistically damage DNA through reactions mediated by the (probably iron-dependent) formation of hydroxyl radical. These considerations prompted the hypothesis that tobacco smoke might contain substances capable of "delocalizing…
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Medical study · Medical research · 1983
Biochemical components of bronchoalveolar lavage in early experimental asbestosis of the sheep: phospholipase A2 activity, prostaglandin E2 and proteins
…significantly increased in both low and high dose groups. These changes in protein and lipid components of BAL following asbestos exposure constitute early indices of lung inflammatory reactions which may contribute to the development of asbestosis.
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Medical study · Medical research · 1978
Corpora amylacea in mesothelioma of the atrioventricular node
… ortochromasia and red birefringence with standardised toluidine blue; positive DMAB-nitrite and diazotisation coupling reactions and spontaneous autofluorescence. It is suggested that these bodies are derived from spontaneous assembly or polymerisation of microfibrils of desquamated cells…
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Medical study · Medical research · 1983
Asbestos-related increase in pulmonary levels of vasoactive intestinal peptide (VIP)
…the pathogenesis of asbestos-related diseases. Exposure to asbestos causes chronic inflammatory reactions in the lung which may lead to fibrosis (1) and increase the incidence of pleuropulmonary cancers (2). Little is known concerning the biochemical…
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Medical study · Medical research · 2000
Role of Iron in the Cellular Effects of Asbestos
…investigations. Asbestos catalyzes many of the same reactions that iron does, including lipid peroxidation and DNA damage. At physiological pH, mobilization of iron from the fibers by a low-molecular-weight chelator greatly enhances these reactions…
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Medical study · Medical research · 1998
The value of anti-calretinin antibody in the differential diagnosis of normal and reactive mesothelia versus metastatic tumors in effusion cytology
…effusions. Metastatic carcinoma cells were detected with anti-Ber-EP4 in 83% of malignant effusions. Non-specific positive reactions for Ber-EP4 in single mesothelial cells were observed in 16% of all cases and, moreover, frequently…
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Medical study · Medical research · 1997
The role of oxygen free radicals in occupational and environmental lung diseases
…ROS-induced lung injury at different target levels may contribute to similar patterns of cell injury and alterations at the molecular level by initiation, propagation, and autocatalytic chain reactions. Intracellular signalling, activation and inactivation of enzymes…
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Medical study · Medical research · 1992
NHLBI workshop summary. Environmental lung diseases. Relationship between acute inflammatory responses to air pollutants and chronic lung disease
…included microdosimetry of inhaled gases and particles, the transfer of ozone and nitrogen dioxide across the air-tissue interface, oxidative reactions involving nitric oxide, early events leading to lung fibrosis, chronic injury in the proximal alveolar…
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Medical study · Medical research · 2013
Cyclooxygenase-2, epidermal growth factor receptor, and aromatase signaling in inflammation and mesothelioma
…asbestos fibers can cross the membrane barriers inside the body and cause inflammatory and fibrotic reactions. Such reactions are believed to be the mechanism by which asbestos fibers may trigger malignant mesothelioma in the pleural membrane…
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Medical study · Medical research · 1997
Mechanism of asbestos-mediated DNA damage: role of heme and heme proteins
…in the presence of asbestos and hydrogen peroxide/organic peroxide/hydroperoxides. HRP catalyzes oxidation reactions in a manner similar to that of prostaglandin H synthetase. Iron released from asbestos is only partially responsible for DNA damage…
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Medical study · Medical research · 1997
Mechanisms of fiber-induced genotoxicity
…during phagocytosis. Secondary molecules that are more stable than ROS are probably involved in DNA damage. Oxidoreduction reactions originating from cells can induce mutations. Genotoxicity is also demonstrated by chromosomal damage associated with impaired mitosis, as…
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Medical study · Medical research · 1997
Cell signaling pathways elicited by asbestos
…integrins. Alternatively, signaling pathways may be stimulated by active oxygen species generated both during phagocytosis of minerals and by redox reactions on the mineral surface. At least two signaling cascades linked to activation of transcription factors…
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Medical study · Medical research · 2005
Respiratory toxicity of multi-wall carbon nanotubes
…inflammation and fibrosis biochemically and histologically. CNT and ground CNT were still present in the lung after 60 days (80% and 40% of the lowest dose) and both induced inflammatory and fibrotic reactions. At 2 months…