85 results for “Reaction Department”, page 4 of 5
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Medical study · Medical research · 1998
Phase I study of paclitaxel as a radiation sensitizer in the treatment of mesothelioma and non-small-cell lung cancer
…gastrointestinal (GI) toxicity (nausea and vomiting) was also observed at 120 mg/m2. Three of 30 patients developed a hypersensitivity reaction. Six patients had grade 2 lung injury manifested by a persistent cough that required antitussives…
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Medical study · Medical research · 1995
Polymorphism of glutathione S-transferase M1 and lung cancer risk among African-Americans and Caucasians in Los Angeles County, California
…Los Angeles County). Samples of white blood cell DNA sufficient for determination of the GSTM1 genotype by a polymerase chain reaction-based assay were obtained from 342 case patients and 716 control subjects. The odds ratios…
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Medical study · Medical research · 2019
Tumour Treating Fields in combination with pemetrexed and cisplatin or carboplatin as first-line treatment for unresectable malignant pleural mesothelioma (STELLAR): a multicentre, single-arm phase 2 trial
…9%]), and thrombocytopenia (four [5%]). Skin reaction was the only adverse event associated with TTFields and was reported as grade 1-2 in 53 (66%) patients, and as grade 3 in four (5%) patients. No treatment…
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Medical study · Medical research · 1998
Exposure to carbon black: a cancer risk?
…tissues. It is therefore quite understandable that many researchers propose to interpret the changes observed in rat lung tissues after inhalation of carbon black as rat-specific reaction mechanisms that cannot be applied to human tissues…
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Court case · Illinois Appellate Court · December 7, 2021 · in the opinion
Jones v. Pneumo Abex LLC (2021)
…Id. Therefore, he did not anticipate any unfavorable reaction. Id. He further indicated that he would be unable to attend the meeting at Johns-Manville and requested that Brown represent American Brake Shoe Company in connection…
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Court case · Pennsylvania Superior Court · April 15, 2009 · in the opinion
Daley v. AW Chesterton, Inc. (2009)
…become imbedded in lung or other tissue. The reaction consists of the body "walling off" the foreign matter with fibrous cells such that it eventually produces scar-like tissue which builds up over many years. \ \ \ Pulmonary…
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Court case · Pennsylvania Superior Court · July 20, 1992 · in the opinion
Marinari v. Asbestos Corp., Ltd. (1992)
…become imbedded in lung or other tissue. The reaction consists of the body "walling off" the foreign matter with fibrous cells such that it eventually produces scar-like tissue which builds up over many years. ..... Pulmonary…
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Medical study · Medical research · 2018
New Insights on Diagnostic Reproducibility of Biphasic Mesotheliomas: A Multi-Institutional Evaluation by the International Mesothelioma Panel From the MESOPATH Reference Center
…the usefulness of FISH detection of CDKN2A(p16) HD compared to BAP1 loss on the spindle cell component for the separation in ambiguous cases between benign florid stromal reaction from true sarcomatoid component of biphasic mesothelioma…
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Court case · U.S. District Court, Eastern District of Texas · November 12, 1990 · in the opinion
Cimino v. Raymark Industries, Inc. (1990)
…Asbestos fibers, once inhaled, remain in place in the lung, causing a tissue reaction that is slowly progressive and irreversible. Typically, the disease does not manifest itself until years after initial exposure to asbestos fibers. The…
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Court case · U.S. Court of Appeals, Fifth Circuit · August 17, 1998 · in the opinion
Cimino v. Raymark Industries, Inc. (1998)
…the judge. When the proceedings resumed, the district court reprimanded plaintiffs' counsel. Pittsburgh Corning mentions adverse audience reaction on a couple of occasions, but the district court properly handled those matters. Neither of these occurrences, or…
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Court case · Mississippi Supreme Court · February 15, 2018 · in the opinion
Illinois Central Railroad Company v. Oakes EX rel. Hagan (2018)
…the Supreme Court noted that a setoff had occurred in Ayers, and there was no negative reaction or treatment of the setoff in the opinion. According to Ayers: "After reduction for three claimants' comparative negligence from…
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Medical study · Medical research · 2016
New Markers for Separating Benign From Malignant Mesothelial Proliferations: Are We There Yet?
This was a literature review of laboratory tests for telling malignant mesothelioma from benign mesothelial reactions. The authors wrote that five older stains (GLUT-1, p53, IMP-3, epithelial membrane antigen and desmin) worked only in…
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Medical study · Medical research · 2019
Treatment status and safety of crizotinib in 2028 Japanese patients with ALK-positive NSCLC in clinical settings
…included 2028 Japanese patients, and more than half of the patients (56.4%) were nonsmokers. The incidence of adverse drug reactions (ADRs) was 91.6%, and common ADRs (incidence ≥15%) were nausea (32.2%), diarrhea (24…
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Medical study · Medical research · 2019
Phase I study of YS110, a recombinant humanized monoclonal antibody to CD26, in Japanese patients with advanced malignant pleural mesothelioma
…toxicity. Corticosteroid, antihistamine, and acetaminophen administration before each infusion was adopted to limit infusion-related reactions (IRRs). Nine Japanese patients (seven men and two women, mean age of 62.2 years), three in each dosing cohort…
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Medical study · Medical research · 2000
Serologic responses in patients with malignant mesothelioma: evidence for both public and private specificities
…protein. Antibodies to topoisomerase II beta were found in 13 of 14 patients and in 6 of 16 volunteers, though the volunteers' reactions were generally weak. Antibodies to U2AF(65) were found in two patients. Each…
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Medical study · Medical research · 2016
Utility of BAP1 Immunohistochemistry and p16 (CDKN2A) FISH in the Diagnosis of Malignant Mesothelioma in Effusion Cytology Specimens
…might also be useful in effusion cytology specimens, we examined 15 biopsies of epithelial mesotheliomas and 3 benign mesothelial reactions and corresponding effusion cytology paraffin-embedded cell blocks. Four cytology specimens were too scanty for p16…
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Medical study · Medical research · 2014
Randomized phase II trial of pemetrexed/cisplatin with or without CBP501 in patients with advanced malignant pleural mesothelioma
…in the two arms, aside from infusion reactions which occurred in 70% of patients treated with CBP501. While this randomized phase II trial met its primary endpoint of PFS at 4 months, other parameters such as…
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Medical study · Medical research · 1998
Reactive oxygen species: their relation to pneumoconiosis and carcinogenesis
…caused lung immune cells to release an inflammatory signaling protein (TNF-alpha), which the authors linked to metal-driven free radical reactions. The authors concluded that their studies support the hypothesis that ROS are involved in…
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Medical study · Medical research · 2016
Pemetrexed-induced scleroderma-like conditions in the lower legs of a patient with non-small cell lung carcinoma
Pemetrexed, which is used for the treatment of non-small cell lung carcinoma and malignant mesothelioma, induces cutaneous adverse reactions in approximately 20% of patients. There are also reports of the induction of fibrosing disorders. We…
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Medical study · Medical research · 2019
Carbonic anhydrase 9 confers resistance to ferroptosis/apoptosis in malignant mesothelioma under hypoxia
…and acidity provide microenvironment for selection under evolutionary pressure and proliferation in cancer cells. Carbonic anhydrases (CAs) are a superfamily of metalloenzymes present in all life kingdoms, equilibrating the reactions among CO2, bicarbonate and H+. CA9…