985 results for “General Electric”, page 44 of 50
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Medical study · Medical research · 2020
Distinct autophagy-apoptosis related pathways activated by Multi-walled (NM 400) and Single-walled carbon nanotubes (NIST-SRM2483) in human bronchial epithelial (16HBE14o-) cells
…While the present study design provides mechanistic understanding after an acute exposure for the tested CNTs, we believe that the information obtained here would have relevance in better understanding of CNT toxicity and pathogenesis in general.
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Medical study · Medical research · 2021
Generation of human embryonic stem cell models to exploit the EWSR1-CREB fusion promiscuity as a common pathway of transformation in human tumors
…suppressor TP53. We expect the generation of isogenic lines carrying oncogenic fusions in various cell lineages to expand our general understanding of how those single genetic events drive tumorigenesis while providing valuable resources for drug discovery.
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Medical study · Medical research · 2018
Oxidative and cytotoxic stress induced by inorganic granular and fibrous particles
…significantly increase ROS production in A549 cells, but elevated gene expression of SOD2 was observed. The results demonstrated that in general, the ability of particles to generate ROS depends on their number and crystal phase. Therefore…
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Medical study · Medical research · 2024
Asbestos ban policies and mesothelioma mortality in Greece
…31/100000person-years (2010-2019). After 2011, the ASMR for men and the general population stabilized. This stability is important since mesothelioma in men is associated with occupational asbestos exposure. The intriguing discovery of a lower…
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Medical study · Medical research · 2018
Assessment of the potential hazard represented by natural raw materials containing mineral fibres-The case of the feldspar from Orani, Sardinia (Italy)
…the Orani's mine. The procedure proposed herein may be a general tool suitable to identify the mineralogical nature of fibrous minerals in raw materials and assess if they may represent a potential health/environmental hazard.
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Medical study · Medical research · 2024
Colorectal Cancer and Asbestos Exposure: A Women's Health Perspective
…tumor in 47 out of 92 cases. Three women were also affected by synchronous or metachronous peritoneal mesotheliomas. This study revealed a general methodological "gender bias" in scientific research. A significantly higher representation of women in…
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Medical study · Medical research · 2018
Nanomaterial exposure and sterile inflammatory reactions
…nanomaterial modes of action in sterile inflammation could provide early indicators of the biological reactivity of nano-sized chemicals and could direct "safe by design" efforts for improving occupational safety and that of the general population…
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Medical study · Medical research · 1988
Mortality and cancer incidence among marine engineers and machinists in Iceland
…at any particular site. A special survey of smoking status showed that cigarette smoking was not as common among the subjects of the cohort as among the general male population in Reykjavik. These results support the…
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Medical study · Medical research · 1984
Long fibre asbestos in a chrysotile textile worker
…worker and a less pronounced but probably significant shift for the tremolite group. They noted general agreement that long fibres are associated with disease. On that basis they concluded that their findings offered an explanation for…
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Medical study · Medical research · 1981
Asbestos--can it be used safely?
…to crocidolite. For Quebec chrysotile miners and millers, the mesothelioma risk was perhaps three to six times that of the general population, compared with 100-200 times in insulation workers exposed to mixed fibres. Some data…
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Medical study · Medical research · 2015
Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma
…H28 cells), pRB1 (H28 cells) and E2F1 and TYMS activity (except H226 cells) were also evident. E2F1 knockdown decreased cell viability more significantly than TYMS knockdown. In general, thymidine kinase 1, ribonucleotide reductase M1, c-myc…
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Medical study · Medical research · 2012
Unusual DNA mismatch repair-deficient tumors in Lynch syndrome: a report of new cases and review of the literature
…yet, however, there are no data to support the inclusion of these tumors into general screening guidelines for detecting Lynch syndrome, nor are there data to warrant surveillance for these tumors in patients with Lynch syndrome.
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Medical study · Medical research · 2004
Pathological anatomy and molecular pathology
…A reliable pathological diagnosis is the basis for therapeutic, prognostic, and medicolegal consequences. In general, it can be achieved by thoracoscopic inspection with specifically directed biopsy. Furthermore, a description of the peculiarities of each mesothelioma by…
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Medical study · Medical research · 2000
Environmental exposure to asbestos and risk of pleural mesothelioma: review and meta-analysis
…mesothelioma following high environmental exposure to asbestos; however, the available data are insufficient to estimate the magnitude of the excess risk at the levels of environmental exposure commonly encountered by the general population in industrial countries.
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Medical study · Medical research · 2016
Consensus Report of the 2015 Weinman International Conference on Mesothelioma
…as high mobility group box 1 and fibulin-3, are promising. There was general agreement that current treatment for MM, which is based on surgery and standard chemotherapy, has a modest effect on the overall survival…
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Medical study · Medical research · 2012
Bringing together evolution on serpentine and polyploidy: spatiotemporal history of the diploid-tetraploid complex of Knautia arvensis (Dipsacaceae)
…via independent polyplodization and hybridization. The complex eco-geographical pattern together with the incidence of both primary and secondary diploid-tetraploid contact zones makes K. arvensis a unique system for addressing general questions of polyploid research.
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Medical study · Medical research · 1992
Cytotoxicity and anaphase aberrations induced by mineral fibres in cultured human mesothelial cells
…milled rock wool, milled glass wool and coarse rock wool. In general, the MMMF samples were less toxic than the asbestos and erionite samples. All three asbestos types studied induced anaphase aberrations at high (near toxic…
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Medical study · Medical research · 2001
Malignant mesothelioma and asbestos exposure among auto mechanics: appraisal of scientific evidence
…Occupational regulatory policies and guidelines, when based on proper scientific evidence, are invaluable and can prevent avoidable diseases in workers or other exposed individuals in the general public. On the other hand, it is the regulators…
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Medical study · Medical research · 2003
Cape Asbestos, Barking, health and environment: 1928-1946
…Barking, and that its exhaust ventilation was quite up to the general standard and constantly being improved. Reports on the factory environment and information on the health of Cape's workforce that are available for the…
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Medical study · Medical research · 2004
The doctors and the dockers
…The Registrar General's occupational mortality report for 1951, noted excess tumors of the lung and stomach for dockers. Elevated Standardized Mortality Ratios for lung cancer had consistently been calculated by the Registrar General for the…