193 results for “Reaction Department”, page 9 of 10
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Biochemical and Biophysical Research Communications
…solid particles and thus are greatly inhibited by desferrioxamine, a strong iron chelator. However, these reactions are not correlated. 1980s Effects of asbestos on membrane transport and metabolism of benzo(a)pyrene. C. Kandaswami, P.J…
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Biochimica et Biophysica Acta
…a chronic oxidative stress (i.e. smoke), it may behave as a prooxidant, propagating free radical-induced reactions, consuming endogenous antioxidants and inducing DNA oxidative damage. In this context, it may regulate cell growth and death…
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Cancer Science
…patchy parietal mesothelial proliferation lesions. In addition, MWCNT-L induced stronger inflammatory reactions including increased inflammatory cell number and cytokine/chemokine levels in the pleural cavity lavage than MWCNT-S. In contrast, MWCNT-S induced stronger…
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Clinical Cancer Research
…patients received amatuximab maintenance. Combination therapy resulted in no overlapping toxicities. Eleven patients (12.4%) had amatuximab-related hypersensitivity reactions. Responses included partial responses in 33 (40%) and stable disease in 42 (51%). Six-month PFS…
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Critical Reviews in Toxicology
…asbestos. The mesothelium and its reactions: a review. D. Whitaker, J.M. Papadimitriou, M.N. Walters. 1982;10(2):81-144. Review PubMed · Publisher Abstract The origins, nature, and reactions of the mesothelium have intrigued investigators…
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Current Opinion in Pulmonary Medicine
…pulmonary emboli, asbestos exposure, and drug reactions. Differences in the clinical features suggest that a variety of mechanisms operate to induce eosinophilic pleural inflammation and pleural fluid accumulation. Human and animal studies indicate that interleukin (IL…
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Experimental and Molecular Pathology
…results indicate that asbestos-induced TNFalpha gene expression is mediated through a process that involves NF-kappaB activation and free radical reactions. Copyright 1999 Academic Press. 1980s Experimental lesions in rats corresponding to advanced human asbestosis…
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Frontiers in Immunology
…combined with CTLA-4 inhibitors have shown effective clinical responses in the treatment of Diffuse Pleural Mesothelioma (DPM). Although the incidence of adverse reactions is high, they are generally tolerable. Systematic Review Registration: www.inplasy.com…
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Frontiers in Oncology
…lesion remained stable. Imaging assessments indicated stable disease (SD). Throughout the treatment course, no severe adverse reactions resulting in mortality were observed, with only grade II bone marrow suppression and intermittent dry, scaly, and peeling skin…
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Histology and Histopathology
…damage the cytoplasmic membrane resulting in loss of cell elements and exposure of underlying capillaries, and eventually in a series of reactions including macrophage activation, possible release of growth factors and metaplasic reconstruction of lung alveoli…
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Investigational New Drugs
…mg/kg and used for cohort expansion. The most common treatment-related adverse events (AEs) were nausea (56%), decreased appetite (36%), infusion reactions (36%), decreased neutrophil counts (36%), and fatigue (33%). The confirmed ORR was 39%…
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Japanese Journal of Cancer Research
…chelate, ferric nitrilotriacetate (Fe-NTA, induces renal proximal tubular damage, a consequence of iron-catalyzed free radical reactions, that finally leads to a high incidence of renal cell carcinoma (RCC) in rodents. Previous studies have identified…
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Japanese Journal of Clinical Oncology
…included 2028 Japanese patients, and more than half of the patients (56.4%) were nonsmokers. The incidence of adverse drug reactions (ADRs) was 91.6%, and common ADRs (incidence ≥15%) were nausea (32.2%), diarrhea (24…
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Journal of Environmental Monitoring
…as it has developed in the United States of America and elsewhere, including some superficial insights into the reactions of communities to the presence of NOA. These responses to 'contamination' by nature deserve further in-depth…
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Journal of Leukocyte Biology
…TNF-alpha resulted from inhibition at the gene expression level and provide evidence for bidirectional modulation of TNF-alpha production by AMs during inflammatory reactions. Inhibition of alveolar macrophage cytotoxicity by asbestos: possible role of prostaglandins…
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Journal of Occupational Medicine and Toxicology
…and public health issues including regulations and compensation necessitate ongoing alertness, corrections and appropriate reactions in scientific as well as public media and policy advisory bodies. Global use of asbestos - legitimate and illegitimate issues. A.L…
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Life Sciences
…the pathogenesis of asbestos-related diseases. Exposure to asbestos causes chronic inflammatory reactions in the lung which may lead to fibrosis (1) and increase the incidence of pleuropulmonary cancers (2). Little is known concerning the biochemical…
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Medical Hypotheses
…enterocolitica infection should not be disregarded, as the infection may launch chronic immunological reactions resembling those observed among asbestos workers. Cell proliferation and carcinogenesis may share a common basis of permeable plasma membrane clusters. J.A…
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Molecular and Cellular Biochemistry
…77. PubMed Abstract In vivo electron spin resonance (ESR) spectroscopy and whole body imaging were used to investigate the toxicity of biological reactions and organ specific oxidative changes associated with the development of acute asbestosis. Pathogen…
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Molecular Cancer Therapeutics
…asbestos fibers can cross the membrane barriers inside the body and cause inflammatory and fibrotic reactions. Such reactions are believed to be the mechanism by which asbestos fibers may trigger malignant mesothelioma in the pleural membrane…