74 results for “Reaction Department”, page 1 of 4
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Court case · New York Supreme Court · January 10, 2013 · in the opinion
Vega v. Georgia-Pacific, LLC (2013)
…s exhibit 20 is a 1966 study commissioned by UCC which revealed that rats had a more "severe reaction" to Calidria asbestos that had been mined by UCC in California than asbestos that had been mined…
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Court case · Maryland Court of Appeals · August 28, 1996 · in the opinion
Owens-Corning Fiberglas Corp. v. Garrett (1996)
…effect. That OCF had direct knowledge of the hazardous nature of asbestos was evident in 1941, when one of the lawyers in its Legal and Patent Department, having received a letter from a Saranac Doctor, expressed…
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Court case · Illinois Appellate Court · September 18, 2013 · in the opinion
Gillenwater v. Honeywell Intern., Inc. (2013)
…the 30 to 36 months \[sic\] period, however, definite indication of tissue reaction appeared in the lungs of animals inhaling Kaylo dust and therefore, I regret to say, our tentative conclusion quoted above must be altered…
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Medical study · Medical research · 1987
Hydroxyl radical production in the presence of fibres by a Fenton-type reaction
…of people who inhale them. Results in the present study however indicate that these fibres are able to produce hydroxyl radicals in the presence of hydrogen peroxide by a Fenton-type reaction. Since hydroxyl radical is…
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Medical study · Medical research · 2006
Analysis of asbestos-induced gene expression changes in bronchiolar epithelial cells using laser capture microdissection and quantitative reverse transcriptase-polymerase chain reaction
…Extraction of RNA from microdissected tissue followed by quantitative reverse transcriptase-polymerase chain (QRT-PCR) reaction permits the analysis of cell-type or microstructure-specific gene expression changes that occur in response to various stimuli in…
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Medical study · Medical research · 1987
Response of mouse lung to crocidolite asbestos. 1. Minimal fibrotic reaction to short fibres
This was an animal experiment from the University of Manitoba, Winnipeg, on how mouse lungs respond to short crocidolite asbestos fibres. The authors separated short fibres from a standard UICC crocidolite sample. These had a mean length of 0.6…
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Medical study · Medical research · 1992
Generation of hydroxyl radical by crocidolite asbestos is proportional to surface [Fe3+]
…in concentrations varying from 0 to 250 mM. Inclusion of deferoxamine in the reaction mixture provided similar results of diminishing both TBA reactive products and dihydroxybenzoic acid generation. We conclude that oxidant generation by crocidolite is…
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Medical study · Medical research · 1993
Activation of UICC crocidolite: the effect of conversion of some ferric ions to ferrous ions
…The amount of iron in asbestos fibers, its oxidation state, and its availability to specific chelating agents determine their ability to catalyze the aforementioned reactions. In the present study, the activation of UICC crocidolite was achieved…
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Medical study · Medical research · 2003
Asbestos bodies: clues to the mechanism of asbestos toxicity?
…lung, ascorbate was oxidized to oxalate in the presence of H2O2, a reaction inhibited by the iron chelator deferoxamine. The author called this a novel mechanism that may contribute to the pathogenicity of asbestos fibers. Oxidation…
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Medical study · Medical research · 2002
Early inflammatory response to asbestos exposure in rat and hamster lungs: role of inducible nitric oxide synthase
…inducible nitric oxide synthase (iNOS) plays a role in the development of asbestos-related pulmonary disorders. The pulmonary reactions of rats and hamsters upon exposure to asbestos fibers are well known to be disparate. In addition…
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Medical study · Medical research · 1983
Lipid peroxidation in microsomes induced by crocidolite fibres
…produced a concomitant induction in microsomal lipid peroxidation. This increase was very rapid as the reaction was almost complete within 10 min. The ability of these fibres to induce this process after a short period of…
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Medical study · Medical research · 2001
Study of inflammatory responses to crocidolite and basalt wool in the rat lung
…dehydrogenase (LDH) activity were determined in the bronchoalveolar lavage (BAL). Both types of fibers induced a prolonged inflammatory reaction in the lung. All the parameters studied in the experimental groups were more markedly elevated after 3…
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Medical study · Medical research · 1987
Enhanced lipid peroxidation and lysosomal enzyme activity in the lungs of rats with prolonged pulmonary deposition of crocidolite asbestos
…for example 75.87 versus 30.81 mg at three months), and microscopy showed granulomas containing fibres. The fibrotic reaction tended to diminish by seven months. Activity of two lysosomal enzymes, beta-glucuronidase and cathepsin D…
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Medical study · Medical research · 2003
Ascorbic acid modifies the surface of asbestos: possible implications in the molecular mechanisms of toxicity
…consequence of the erosion of the outmost layers while hydration of silica tetrahedra yields new silanol groups. The activity in the Fenton-like reaction (OH from H(2)O(2)) decreases following surface iron depauperation. Conversely…
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Medical study · Medical research · 2001
Free radical generation in the toxicity of inhaled mineral particles: the role of iron speciation at the surface of asbestos and silica
…1.3 to 29 nmol/mg. It also increased one radical reaction, breaking a carbon-hydrogen bond, about 3-fold, while heating in air fully stopped that reaction. The other reaction, hydroxyl radical release from hydrogen…
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Medical study · Medical research · 1987
Response of mouse lung to crocidolite asbestos. 2. Pulmonary fibrosis after long fibres
…These findings suggest that injury to bronchial and bronchiolar epithelium allows long fibres to reach the interstitium where subsequent macrophage-fibroblast interactions result in a severe fibrotic reaction that resembles the bronchiolar component of human asbestosis.
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Medical study · Medical research · 1987
Crocidolite-induced lipid peroxidation in rat lung microsomes. I. Role of different ions
…in rat lung microsomes both from rats pretreated with 3-methylcholanthrene and from untreated controls. This increase was dependent on the concentration of these ions in the reaction mixture. Crocidolite alone increased peroxidation in microsomal fractions…
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Medical study · Medical research · 2011
A 3-dimensional in vitro model of epithelioid granulomas induced by high aspect ratio nanomaterials
The most common causes of granulomatous inflammation are persistent pathogens and poorly-degradable irritating materials. A characteristic pathological reaction to intratracheal instillation, pharyngeal aspiration, or inhalation of carbon nanotubes is formation of epithelioid granulomas accompanied by…
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Court case · California Court of Appeal · March 17, 2017 · in the opinion
Phillips v. Honeywell International Inc. (2017)
…goal of installing brakes weakens the inference that Phillips reaction to a warning on the boxes of Bendix brakes would have been the same as his reaction to the warning on cigarette packaging when he started…
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Medical study · Medical research · 2021
MicroRNA expression in lung tissues of asbestos-exposed mice: Upregulation of miR-21 and downregulation of tumor suppressor genes Pdcd4 and Reck
…mice four times weekly. We extracted total RNA from lung tissues and performed microarray analysis for miRNA and gene expression. We also carried out real-time polymerase chain reaction (PCR), Western blotting, and immunohistochemistry to confirm…