13 results for “Reaction Department”
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Medical study · Medical research · 1983
Acute lung response to amosite asbestos: a morphological study
This was an animal experiment in guinea pigs. It examined the lung's reaction during the week after amosite asbestos was placed in the windpipe. Exposed animals received 17.5 mg of ground commercial-grade amosite…
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Medical study · Medical research · 1994
Iron associated with asbestos bodies is responsible for the formation of single strand breaks in phi X174 RFI DNA
…iron was responsible. Amosite fibres (5000 fibres/reaction), with a similar length distribution to that of the asbestos bodies, did not catalyse detectable amounts of single strand breaks in DNA under identical reaction conditions. The results…
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Medical study · Medical research · 1985
Pathologic changes in the small airways of the guinea pig after amosite asbestos exposure
… where these fibers penetrated the airway walls, an interstitial inflammatory and fibrotic reaction (asbestosis) occurred. It is concluded that 1) amosite asbestos produces diffuse abnormalities throughout the noncartilagenous airways and possibly the cartilagenous airways as well…
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Medical study · Medical research · 1998
Mineral dusts directly induce epithelial and interstitial fibrogenic mediators and matrix components in the airway wall
…titanium dioxide. Explants were then maintained in air organ culture, and the expression of genes encoding for various mediators and matrix components assessed by reverse transcriptase-polymerase chain reaction (RT-PCR). At 7 d, all dusts…
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Medical study · Medical research · 1983
Effect of intrabronchially instilled amosite on lavagable lung and pleural cells
…the study. No pleural reaction was seen in the saline instilled group. The inflammatory reactions indicated by the composition of the lavaged cells of the lung represent the in vivo toxicity of intrabronchially instilled amosite. The…
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Medical study · Medical research · 1984
Asbestos catalyzes hydroxyl and superoxide radical generation from hydrogen peroxide
…hydroxyl radicals from a normal byproduct of tissue metabolism, hydrogen peroxide. The iron chelator desferroxamine inhibits this reaction, indicating a major role for iron in the catalytic process, and suggesting a possible mechanism by which asbestos…
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Medical study · Medical research · 2001
Sorption of nonpolar aromatic contaminants by chlorosilane surface modified natural minerals
…headgroups and chemical properties. Silanol groups of the diatomite and zeolite were modified by chemical reaction with the chlorosilanes resulting in a stable covalent attachment of the organosilanes to the mineral surface. The alteration of surface…
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Medical study · Medical research · 2009
Renal, vascular and cardiac fibrosis in rats exposed to passive smoking and industrial dust fibre amosite
…apparent particularly in changes of vascular structure. Advanced oxidation protein products, the plasma marker of the myeloperoxidase reaction in activated monocytes/macrophages, were increased in all exposed groups, whereas the inflammatory cytokines did not differ between…
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Medical study · Medical research · 1989
Lung cell reactions in guinea pigs after inhalation of asbestos (amosite)
…blood vessels and in connection with the bronchioles. The data suggest that amosite at low doses ultimately causes fibrosis with a reaction pattern different from that seen in silicosis. The inflammation and fibrosis seems to develop…
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Medical study · Medical research · 1997
Short-term inhalation and in vitro tests as predictors of fiber pathogenicity
…and SiC. However, measurements of BrdU uptake into lung cells showed that amosite and SiC produced a greater reaction than code 100/475, which itself caused no more proliferation than that seen in untreated lungs. These…
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Medical study · Medical research · 2003
Long and short fiber amosite asbestos alters at a different extent the redox metabolism in human lung epithelial cells
…cells A549, long amosite fibers, more effectively than the short ones, initiate free radical reactions, inhibit the glucose 6-phosphate dehydrogenase activity and the pentose phosphate pathway, decrease the intracellular level of reduced glutathione, and increase…
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Medical study · Medical research · 1986
Studies on the role of oxygen radicals in asbestos-induced cytopathology of cultured human lung mesothelial cells
…after exposure to amosite asbestos, although oxygen radicals were readily detected in cells exposed to menadione, an uncoupler of oxidation-reduction reactions. Cellular thiol levels were reduced after exposure to menadione, but were not affected by…
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Medical study · Medical research · 1981
Comparative pulmonary responses to inhaled inorganic fibers with asbestos and fiberglass
…rats and hamsters but not in guinea pigs. Fine fiberglass particles were not fibrogenic. Rats revealed more fibrogenic pulmonary reactions than guinea pigs or hamsters. A few pulmonary tumors developed in animals exposed to asbestos, Fybex…