43 results for “Reaction Department”, page 1 of 3
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Medical study · Medical research · 1984
Fiber localization and its relationship to lung reaction in rats after chronic inhalation of chrysotile asbestos
…with histologic changes indicating marked epithelial injury. Increased amounts of fibers are also localized in the lung interstitium with continued exposure to asbestos and are associated with a progressive interstitial fibrotic reaction. Following cessation of exposure…
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Medical study · Medical research · 1986
Gallium scanning in differentiating malignant from benign asbestos-related pleural disease
…no history of exposure. Scans were also positive in 3 of the 16 patients with benign disease (19%), and tissue removed from these three showed a strong inflammatory reaction. Among asbestos-exposed patients, the scan's…
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Medical study · Medical research · 1977
Immune adherence reactivity of rat alveolar macrophages following inhalation of crocidolite asbestos
…a statistically significant difference. Sheep red cells, which cannot take part in this reaction, stuck far less to macrophages from exposed rats. Treating the cells with antiserum against the complement component C3 reduced adherence to 4…
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Medical study · Medical research · 1985
Pathologic changes in the small airways of the guinea pig after amosite asbestos exposure
… where these fibers penetrated the airway walls, an interstitial inflammatory and fibrotic reaction (asbestosis) occurred. It is concluded that 1) amosite asbestos produces diffuse abnormalities throughout the noncartilagenous airways and possibly the cartilagenous airways as well…
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Medical study · Medical research · 2003
Asbestos bodies: clues to the mechanism of asbestos toxicity?
…lung, ascorbate was oxidized to oxalate in the presence of H2O2, a reaction inhibited by the iron chelator deferoxamine. The author called this a novel mechanism that may contribute to the pathogenicity of asbestos fibers. Oxidation…
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Medical study · Medical research · 2002
Early inflammatory response to asbestos exposure in rat and hamster lungs: role of inducible nitric oxide synthase
…inducible nitric oxide synthase (iNOS) plays a role in the development of asbestos-related pulmonary disorders. The pulmonary reactions of rats and hamsters upon exposure to asbestos fibers are well known to be disparate. In addition…
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Medical study · Medical research · 1982
A study of macrophage-mediated initiation of fibrosis by asbestos and silica using a diffusion chamber technique
…the chamber) from the target tissue. Fibrous reactions surrounding the chambers were quantitated by macroscopic and histological scoring, and by measurement of 14C glycine incorporated at the reaction site. Using this model the fibrogenicity of Rhodesian…
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Medical study · Medical research · 2004
Re: Controlled use of asbestos
…which were not published, reported fibrotic lesions or lung damage; in 1966 the Coalinga sample produced the most severe reaction. The authors stated that UCC consultants misrepresented Pinkerton's data. Their review of King City mine…
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Medical study · Medical research · 1965
Asbestos and neoplasia: diffuse mesothelial tumors. Criteria for diagnosis of diffuse mesothelial tumors
…periodic acid-Schiff reaction was nearly always negative. A colleague found hyaluronidase-removable acid mucopolysaccharide in all 17 mesotheliomas examined and in none of 20 adenocarcinomas. However, the author had seen an identical reaction in pleural…
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Medical study · Medical research · 1989
Reactions of asbestos-exposed workers to notification and screening
…In this study, we assessed reactions of asbestos-exposed workers to a letter notifying them of their risk for asbestos-related illnesses and the availability of a medical screening program. Two hundred forty-seven workers who…
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Medical study · Medical research · 1983
Small-airway lesions in patients exposed to nonasbestos mineral dusts
…which they call mineral dust airways disease, is a nonspecific reaction of the small airways to inorganic particulates. The presence of such changes casts considerable doubt on the theory that small-airway abnormalities in asbestos workers…
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Medical study · Medical research · 1983
A murine model of asbestosis
…an initial macrophage reaction was found to progress to "asbestos body" formation and diffuse focal interstitial fibrosis within 1 year of a chronic exposure period. This reaction was most intense in areas adjacent to respiratory bronchioles…
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Medical study · Medical research · 2020
Evaluation of soluble mesothelin-related peptides and MSLN genetic variability in asbestos-related diseases
…154 had MM. Serum SMRP levels were determined using sandwich enzyme-linked immunosorbent assay. All subjects were genotyped for MSLN rs1057147 polymorphism using competitive allele-specific polymerase chain reaction. Nonparametric tests, logistic and Cox regression were…
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Medical study · Medical research · 2023
The association of genetic factors with serum calretinin levels in asbestos-related diseases
…genotyped for seven polymorphisms in CALB2, E2F2, MIR335, NRF1 and SEPTIN7 genes using competitive allele-specific polymerase chain reaction (PCR). Serum calretinin was determined with ELISA in 545 subjects. Nonparametric tests, logistic regression and receiver operating…
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Medical study · Medical research · 1978
Experimental asbestosis: an investigation of functional and pathological disturbances. II. Results for chrysotile and amosite exposures
…not until about 70 weeks for animals exposed when three months old. No fibrotic reaction was seen during the 70 weeks of the amosite experiments. The relationships between pathological and functional changes throughout these experiments are…
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Medical study · Medical research · 1988
Railroad workers with pleural plaques: II. Small airway dysfunction among asbestos-exposed workers
…groups the VTG:TLC ratio was elevated compared with controls. Increased VTG is a sign of small airways dysfunction. In asbestos-exposed subjects, it might be caused by an early peribronchial reaction to inhaled asbestos fibers.
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Medical study · Medical research · 2009
Association of transforming growth factor beta1 gene polymorphisms and asbestos-induced fibrosis and tumors
…Therefore, we examined an association between the 2 TGF-beta1 gene polymorphisms and asbestos-induced lung fibrosis and lung cancer. Detection of the 2 polymorphisms was performed by rapid capillary polymerase chain reaction, with melting curve…
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Medical study · Medical research · 1981
Diminished suppressor cell function in patients with asbestosis
…patients. Skin reaction to dinitrochlorobenzene (DNCB) was not depressed, although lymphocytes of patients giving positive skin test reactions demonstrated a significantly lower (P less than 0.001) proliferative response to dinitrobenzene sulphonic acid (DNBSO3) in vitro…
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Medical study · Medical research · 1974
Correlation between the tissue response and asbestos fiber content
…and here secondary factors may be concerned. Electron microscopy suggests that optically visible fibers constitute a reasonably constant proportion of the total irrespective of the pathological reaction. Light microscopy may thus afford a guide to the…
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Medical study · Medical research · 2003
Oxalate deposition on asbestos bodies
…vitro generated approximately 42 nmol of oxalate in 24 hours. Oxalate generation was diminished significantly by the inclusion of either deferoxamine or dimethylthiourea in the reaction mixture. Incubation of asbestos bodies and uncoated fibers isolated from…