76 results for “Reaction Department”, page 1 of 4
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Medical study · Medical research · 2017
Mesothelioid reaction following talc pleurodesis: a case report
…Such a mesothelioid reaction can clinically and radiographically mimic malignant mesothelioma. We conclude that Talc pleurodesis played a causative role in this patient developing an intense mesothelioid reaction. A mesothelioid reaction should be included in the…
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Medical study · Medical research · 2015
Disseminated Pleural Siliconoma Mimicking Malignant Pleural Mesothelioma
This case report from a thoracic surgery department in Ube, Japan, described one 48-year-old woman with multiple nodules on the lining of her left lung (the pleura). She had received silicone breast implants 10…
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Medical study · Medical research · 2012
Toxic epidermal necrolysis related to Cisplatin and pemetrexed for metastatic non-small cell lung cancer
Toxic epidermal necrolysis (TEN) is an uncommon but life-threatening adverse drug reaction. Pemetrexed is a multitargeted antifolate. It was first used in combination with cisplatin as a front-line treatment for malignant pleural mesothelioma. The…
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Medical study · Medical research · 2017
Secondary hypertrophic osteoarthropathy caused by non-pleural or pulmonary tumors
Hypertrophic osteoarthropathy (HOA) is a rare paraneoplastic syndrome characterized by digital clubbing, periosteal reaction, polyarthralgia, arthritis, and synovitis. Herein, we report a case series of patients with secondary HOA caused by non-pleural or pulmonary tumors…
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Medical study · Medical research · 2016
BAP1 Immunohistochemistry and p16 FISH in the Diagnosis of Sarcomatous and Desmoplastic Mesotheliomas
…help diagnose sarcomatous and desmoplastic mesotheliomas. These tumors can be hard to distinguish from organizing pleuritis, a benign reaction of the pleura. The authors tested tissue from 20 such pleural mesotheliomas, from 18 men and 2…
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Medical study · Medical research · 1986
US surgeon general ignites furor with findings on smoking in the workplace
…research study. A freelance writer described the US Surgeon General's December 1985 Smoking and Health report on cancer and chronic lung disease in the workplace, and the reaction to it. According to the article, the…
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Medical study · Medical research · 2018
Pemetrexed-induced painful erythematous nodules in both legs in a patient with recurrent mesothelioma
…supported considering the reaction a drug-induced hypersensitivity. They reported her as the first patient described with such lesions while receiving pemetrexed for mesothelioma, adding a nodular form to the known skin reactions to this drug…
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Medical study · Medical research · 2017
CAR T-cell therapy for lung cancer and malignant pleural mesothelioma
…The review also described earlier studies. One was a University of Pennsylvania trial that treated four patients; one patient had a serious anaphylactic reaction. Others were the authors' own mouse experiments, in which giving mesothelin-targeted…
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Medical study · Medical research · 1987
Immunohistological staining of reactive mesothelium, mesothelioma, and lung carcinoma with a panel of monoclonal antibodies
…but was present in most of the lung carcinomas. CEA seemed to be the single most useful marker in distinguishing carcinoma from mesothelioma in that a positive reaction for CEA would indicate carcinoma rather than mesothelioma.
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Medical study · Medical research · 2013
Diffuse intrapulmonary malignant mesothelioma masquerading as interstitial lung disease: a distinctive variant of mesothelioma
…micropapillary, and solid patterns. Initial diagnoses by referring pathologists included reactive changes (1), hypersensitivity pneumonitis versus drug reaction (1), desquamative interstitial pneumonia versus neoplasm (1), and mesothelioma (2). Microscopic pleural involvement was identified in 4 cases…
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Medical study · Medical research · 1992
Immunohistochemical study of 158 lung carcinomas
…carcinomas. The marker CEA stained only 33% of small cell and 60% of large cell carcinomas, and eight (26%) poorly differentiated squamous cell carcinomas showed no reaction. EMA stained about 90% of all four tumour groups…
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Medical study · Medical research · 1981
The biological effects of mineral fibres
…In the studies reviewed, glass fibres injected into animals' body cavities produced mesotheliomas, while inhaled glass fibre produced little tissue reaction. Studies of glass fibre workers had so far been negative. The review also described reports…
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Medical study · Medical research · 2022
Artichoke phytocomplex modulates serum microRNAs in patients exposed to asbestos: a first step of a phase II clinical trial
…193a-5p, also appeared in earlier mesothelioma data. Of 21 men who took AWPC, 11 reported at least one adverse reaction. None were considered serious. AWPC was suspected as the cause in 3 men, all of…
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Medical study · Medical research · 1984
Quantitative x ray microanalysis of pulmonary mineral particles in a patient with pneumoconiosis and two primary lung tumours
…fire clay mineral. The authors concluded the method reliably identified individual particles. They noted it cannot show whether the dust caused the tissue reaction, and that the particles analysed probably did not represent all minerals present.
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Medical study · Medical research · 2001
Cutaneous toxicity after intradermal vaccination with Mycobacterium vaccae against lung cancer and malignant mesothelioma
This letter reported two patients at the Royal Marsden Hospital who developed unusual skin reactions after injections into the skin of SRL172, a heat-killed Mycobacterium vaccae vaccine being tested against cancer. The first, a 52…
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Medical study · Medical research · 2013
Melan A (A103) is not a marker of mesothelioma
…supplier (Lab Vision). The authors concluded that melan A (A103) is not expressed in mesotheliomas and that the earlier positive results most likely reflected a false-positive reaction of that antibody. The study did not examine…
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Medical study · Medical research · 2017
Malignant peritoneal mesothelioma and Crohn disease
Mesothelial reaction simulating peritoneal diffuse malignant mesothelioma (MM) has been reported in the setting of Crohn ileitis. To our knowledge, peritoneal MM arising in patients with inflammatory bowel disease (IBD) has not been reported. The purpose…
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Medical study · Medical research · 2016
SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma
…molecular targets for the development of more effective therapies for MPM. Using quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) and an RNA interference-based screening, we examined the SORORIN gene as potential therapeutic targets for…
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Medical study · Medical research · 2011
Is a single nucleotide polymorphism a risk factor for lung cancer in the matrix metalloproteinase-2 promoter?
…200 lung cancer patients + 100 no lung cancer) were analyzed. Polymorphisms were determined by using polymerase chain reaction-restriction fragment length polymorphism (RFLP) and electrophoresis. Plasma MMP-2 enzyme activity levels were measured by using ELISA…
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Medical study · Medical research · 2013
Diagnostic usefulness of p16/CDKN2A FISH in distinguishing between sarcomatoid mesothelioma and fibrous pleuritis
…examination is inconclusive. We studied the usefulness of deletion of p16 with fluorescence in situ hybridization (FISH) and p16 hypermethylation with polymerase chain reaction for the diagnosis and prognosis of malignant pleural mesothelioma (MPM). We analyzed…