Trimodality therapy is a treatment approach for mesothelioma that combines three types of treatment: surgery, chemotherapy, and radiation. The goal is to remove or destroy as much cancer as possible using each method's strengths. It's an aggressive plan usually offered to selected patients whose disease and overall health make them candidates.
Origin
The term combines "tri" (three) with "modality," meaning a method of treatment. The approach developed for pleural mesothelioma in the late 20th and early 21st centuries as specialists combined surgery with chemotherapy and radiation to improve outcomes.
Significance in Asbestos Context
For a mesothelioma patient, trimodality therapy represents the most aggressive curative-intent option, and whether it's offered depends on the cancer's stage, cell type, and the patient's fitness for major surgery. It typically pairs a lung-sparing or lung-removing operation with chemotherapy before or after surgery and radiation to the chest. Because it's demanding, patients weigh the potential benefits against significant recovery and side effects, often at specialized mesothelioma centers. The intensity and cost of this treatment are frequently part of documenting damages in a claim, since they reflect both the seriousness of the disease and the medical expenses incurred.
Example Sentence
After his early-stage diagnosis, the tumor board discussed whether he was a candidate for trimodality therapy at a specialized mesothelioma center.
Related Terms
Pleurectomy, Extrapleural Pneumonectomy, Chemotherapy, Radiation Therapy, Mesothelioma, Multimodal Treatment
Notes
- Ask whether you're a candidate and seek evaluation at a specialized mesothelioma program experienced with this approach.
- Keep detailed records of all three treatment phases and their costs, since they support the medical-damages part of a claim.
- Ask your team to explain the expected benefits, risks, and recovery for your specific stage and cell type.
In the research library
32 studies in our medical research library mention Trimodality Therapy in the title or abstract. Among the most cited:
- Patterns of failure after trimodality therapy for malignant pleural mesotheliomaE.H. Baldini, A. Recht, G.M. Strauss, et al, 1997 · The Annals of Thoracic Surgery · cited 229 times
- Trimodality therapy for malignant pleural mesothelioma: results from an EORTC phase II multicentre trialP.E. Van Schil, P. Baas, R. Gaafar, et al, 2010 · The European Respiratory Journal · cited 180 times
- Survival after trimodality therapy for malignant pleural mesothelioma: Radical Pleurectomy, chemotherapy with Cisplatin/Pemetrexed and radiotherapyS. Bölükbas, C. Manegold, M. Eberlein, et al, 2011 · Lung Cancer · cited 109 times
- Improved Outcomes with Modern Lung-Sparing Trimodality Therapy in Patients with Malignant Pleural MesotheliomaF. Shaikh, M.G. Zauderer, D. von Reibnitz, et al, 2017 · Journal of Thoracic Oncology · cited 52 times
- Integrated positron emission tomography-computed tomography does not accurately stage intrathoracic disease of patients undergoing trimodality therapy for malignant pleural mesotheliomaJ. Pilling, J.A. Dartnell, L. Lang-Lazdunski, 2010 · The Thoracic and Cardiovascular Surgeon · cited 22 times
The journals that publish most on it: Journal of Thoracic Oncology (7), Lung Cancer (4), Current Treatment Options in Oncology (2).
Category: Treatments & Therapies · All Lexicon terms A–Z
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