Absence of estrogen immunoreactivity in adenomatoid tumors of male reproductive system

Our plain-English summary of Absence of estrogen immunoreactivity in adenomatoid tumors of male reproductive system, by J.I. Lopez, F.I. Aranda (Pathology, Research and Practice, 1990).

The study

• Authors: J.I. Lopez, F.I. Aranda
• Journal: Pathology, Research and Practice
• Published: 1990;186(3):395-6
• Read it: PubMed · Publisher

In plain English

This short report, by two authors from hospital pathology departments in Spain, examined six adenomatoid tumors of the male reproductive system. Adenomatoid tumors are uncommon, non-cancerous (benign) growths found mainly in the genital and urinary region. The authors noted that most investigators believe these tumors come from mesothelial cells, the type of cell that lines body cavities. The authors stained preserved tissue from the six cases with antibodies to see which markers the tumor cells carried. All six cases showed a mesothelial pattern and stained positive for cytokeratins. Staining for estradiol, a form of estrogen, was consistently negative. So was staining for factor VIII associated antigen. The authors stated that, to their knowledge, estrogen immunoreactivity had not previously been reported for these tumors. They called their results preliminary. They said further work using several types of antisera was needed to determine how these tumors respond to the hormone. The article does not mention asbestos. It gives no details about the patients, such as their ages or where the tumors were found.

We wrote this plain-English summary from the full article with the help of AI, and a second AI model checked each sentence against the article. It is not the authors' wording; the abstract and the article are their own account.

What the study did and found

• Design: small case series examined by immunohistochemistry (antibody staining of preserved tissue)
• Who was studied: six cases of adenomatoid tumor of the male reproductive system. Patient ages, tumor sites, the source of the cases and the dates are not given.
• Exposure: No asbestos or other environmental exposure was studied. The study tested the tumors for estradiol (estrogen) staining.
• Main results:
  • All six cases showed a mesothelial immunophenotype. Wide-spectrum and low molecular weight cytokeratins stained positive.
  • Estradiol staining and factor VIII associated antigen staining were consistently negative in the cases.
• The authors' conclusion: The authors stated that, to their knowledge, estrogen immunoreactivity had not previously been reported in adenomatoid tumors. They described their results as preliminary and needing further evidence.
• Limitations the authors state:
  • The authors called the results preliminary. They said several types of antisera should be used to determine how these tumors respond to the hormone.

Topics

The National Library of Medicine indexes this study under subjects our site covers: Mesothelioma.

Medical terms in this study, explained in our Lexicon: Adenomatoid Tumor.

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• Histogenesis and classification of mesonephric tumors of the female and male genital system and relationship to benign so-called adenomatoid tumors (mesotheliomas); a comparative histological study — G. Teilum (1954)
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• Adenomatoid tumour of the epididymis: histochemical and ultrastructural study of 2 cases — M. Nistal, F. Contreras, et al. (1978)

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