Adenomatoid prostatic tumor

Our plain-English summary of Adenomatoid prostatic tumor, by K.T. Chen, J.J. Schiff (Urology, 1983).

The study

• Authors: K.T. Chen, J.J. Schiff
• Journal: Urology
• Published: 1983;21(1):88-9
• Type of article: Case report
• Cited by: 24 articles, as counted by NIH iCite
• Read it: PubMed · Publisher

Abstract

A prostatic tumor is presented that histologically resembles adenomatoid tumor arising in other sites. The intraprostatic location and positive prostatic acid phosphatase immunoperoxidase staining support prostatic epithelial origin of the tumor. This study further confirms the histogenetic heterogeneity of the adenomatoid tumor.

PubMed has no abstract for this study. This is the authors' abstract, copied from the article.

In plain English

This article was a case report about one patient at Fresno Community Hospital and Medical Center in California. It did not discuss asbestos or any other exposure. A 62-year-old man with a three-year history of urinary hesitancy, urgency and frequency was seen for acute urinary retention, and tissue from his enlarged prostate was removed by transurethral resection. Under the microscope the tissue showed benign glandular hyperplasia and a 7-mm circumscribed, nonencapsulated nodule. The nodule was made of irregular gland-like spaces lined by a single layer of cells, and no mitotic activity (cell division) was seen. The authors judged the nodule characteristic of the adenoid type of adenomatoid tumor. They wrote that this tumor type had not been reported in the prostate before, and they distinguished it from prostate cancer by its growth pattern and the absence of malignant cell features. The tumor cells stained strongly for prostatic acid phosphatase, an enzyme found in the prostate. Earlier studies, cited in the article, link adenomatoid tumors to mesothelial cells. The authors concluded that this tumor was likely of prostatic epithelial origin and that adenomatoid tumors do not all share one origin.

We wrote this plain-English summary from the full article with the help of AI, and a second AI model checked each sentence against the article. It is not the authors' wording; the abstract and the article are their own account.

What the study did and found

• Design: case report
• Who was studied: One 62-year-old man with a three-year history of urinary hesitancy, urgency and frequency, seen for acute urinary retention; the authors were at Fresno Community Hospital and Medical Center, Fresno, California (published 1983)
• Exposure: No exposure was studied. The article does not mention asbestos or any occupational or environmental exposure.
• Main results:
  • The transurethral resection specimen weighed 50 Gm and showed benign glandular hyperplasia and a 7-mm circumscribed, nonencapsulated nodule
  • The nodule's gland-like spaces were lined with a single layer of low columnar, cuboidal or flattened cells, with no mitotic activity
  • A trichrome stain showed no smooth muscle tissue, and a reticulin stain showed prominent branching and anastomosis of the gland-like spaces
  • The tumor cells stained strongly for prostatic acid phosphatase
  • The authors judged the features characteristic of the adenoid type of adenomatoid tumor and stated that a location in the prostate had not been reported previously
• The authors' conclusion: The authors concluded that the positive prostatic acid phosphatase staining and the location inside the prostate strongly supported a prostatic epithelial origin for this tumor, rather than the mesothelial origin generally accepted for adenomatoid tumors. They said this further confirmed that adenomatoid tumors do not all have the same origin, and that the term 'adenomatoid tumor' should remain in use for light-microscopic diagnosis.

Topics

The National Library of Medicine indexes this study under subjects our site covers: Mesothelioma.

Medical terms in this study, explained in our Lexicon: Adenomatoid Tumor.

Related studies

• Histogenesis and classification of mesonephric tumors of the female and male genital system and relationship to benign so-called adenomatoid tumors (mesotheliomas); a comparative histological study — G. Teilum (1954)
• Adenomatoid tumors of the uterus — J.C. Quigley, W.R. Hart (1981)
• Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation — B. Goode, N.M. Joseph, et al. (2018)
• Immunoperoxidase localization of keratin proteins, carcinoembryonic antigen, and factor VIII in adenomatoid tumors: evidence for a mesothelial derivation — J.W. Said, G. Nash, et al. (1982)
• Are all adenomatoid tumors adenomatoid mesotheliomas? — C.L. Davy, C.K. Tang (1981)
• Suprarenal occurrence of an adenomatoid tumor — C.P. Evans, J.A. Vaccaro, et al. (1988)

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