Cytopathologic diagnosis in pleural effusion and cyto-histopathologic correlation

Our plain-English summary of Cytopathologic diagnosis in pleural effusion and cyto-histopathologic correlation, by A.F. Dağli, S. Küçük, M. Sezer, et al (Türk Patoloji Dergisi, 2011).

The study

• Authors: A.F. Dağli, S. Küçük, M. Sezer, O. Uçer
• Journal: Türk Patoloji Dergisi
• Published: 2011;27(1):12-6
• Cited by: 8 articles, as counted by NIH iCite
• Read it: PubMed · Publisher

Abstract

Objective: Cytological examination of pleural fluids is a fast, efficient and non-invasive diagnostic method. Identification of malignant effusions bears critical importance in treatment and prognosis. The aim of this study was to investigate the distribution of cytopathologic diagnoses in pleural effusions and the cyto-histopathologic correlation rates.

Material And Method: A total of 298 pleural fluid cases diagnosed from 2008 to 2009 in our laboratory were retrospectively identified as the study group. Evaluation results were classified in 5 groups as inconclusive, benign, atypical, suspicious and malignant, and compared with the biopsy results.

Results: Of the total 298 pleural fluid cases, 114 (38.3%) were females and 184 (61.7%) were males. The age range was between 15 and 89 with a mean value of 58.4 +/- 17.8. Of the cases, 3 (1%) were diagnosed as inadequate, 246 (82.6%) benign, 8 atypical, 10 suspicious, and 31 malignant by cytology. Among the cases who were diagnosed as malignant, 24 (8.1%) were reported as metastatic carcinoma and 7 (2.3%) as malignant mesothelioma. Of the 8 cases reported as atypical, biopsy results of 2 showed malignant mesothelioma, and of the 10 cases reported as suspicious, 1 case whose biopsy result was obtained was diagnosed as epidermoid carcinoma metastasis.

Conclusion: Cytological examination is the most valuable diagnostic method for pleural effusions which may have various etiological causes. The most common cause of pleural effusions in our region is metastatic carcinomas including those from the lung, breast and ovarian tumors, followed by malignant mesothelioma.

In plain English

This entry cannot yet summarize the cited study. The citation is for an article by Dağli and colleagues whose title describes diagnosing pleural effusions (fluid around the lungs) by examining cells in the fluid, and comparing those cell findings with tissue findings. That article appears on pages 12 to 16 of the 2011 Turkish Journal of Pathology. The text supplied with the citation is a different article from the same issue (pages 17 to 22), by Tuncer and colleagues. It studied two proteins, p16 and cyclin D1, in tumor tissue from 31 patients with cancers of the pancreas or the ampulla of Vater, an opening into the small intestine. That article does not deal with asbestos, mesothelioma or pleural fluid. Its findings belong to that article, so they are not reported here as results of the cited study. A summary of the pleural effusion study needs the correct full text, and the library should obtain it before this entry is completed.

We wrote this plain-English summary from the full article with the help of AI, and a second AI model checked each sentence against the article. It is not the authors' wording; the abstract and the article are their own account.

Topics

Medical terms in this study, explained in our Lexicon: Pleural Effusion, Prognosis, Biopsy, Cytology, Carcinoma, Malignant Mesothelioma, Metastasis.

Related studies

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• Evaluation of seven tumour markers in pleural fluid for the diagnosis of malignant effusions — M. Miédougé, P. Rouzaud, et al. (1999)
• A diagnosis of malignant pleural mesothelioma can be made by effusion cytology: results of a 20 year audit — A. Segal, G.F. Sterrett, et al. (2013)
• Loss of expression of BAP1 is a useful adjunct, which strongly supports the diagnosis of mesothelioma in effusion cytology — J. Andrici, A. Sheen, et al. (2015)
• Cytological differential diagnosis among adenocarcinoma, epithelial mesothelioma, and reactive mesothelial cells in serous effusions by immunocytochemistry — X.Y. Su, G.D. Li, et al. (2011)
• Use of cholesterol and soluble tumour markers CEA and syndecan-2 in pleural effusions in cases of inconclusive cytology — M. Gulyas, J. Fillinger, et al. (2019)

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