Postgraduate Medical Journal

Our medical research library holds 10 studies published in Postgraduate Medical Journal (1966–2018). Each entry links to the study's record on PubMed and, where there is one, to the publisher's page and a free full text. 8 have an abstract, the authors' own summary as PubMed records it: open "Abstract" to read it.

About the journal

• Publisher: Oxford University Press
• Published: 1925 to the present, England
• Language: English
• ISSN: 0032-5473 (print), 1469-0756 (electronic)
• Its record in the NLM Catalog

2010s

• Abdominal mass as a manifestation of mesothelioma. A.J. Martín-Jiménez, V. Aragón-Domínguez, I. Trouillhet-Manso, et al. 2018;94(1116):604. Case report PubMed · Publisher

2000s

• History of asbestos related disease. P.W. Bartrip. 2004;80(940):72-6. Historical article PubMed · Publisher · Free full text

  Abstract

  The first medical article on the hazards of asbestos dust appeared in the British Medical Journal in 1924. Following inquiries by Edward Merewether and Charles Price, the British government introduced regulations to control dangerous dust emissions in UK asbestos factories. Until the 1960s these appeared to have addressed the problem effectively. Only then, with the discoveries that mesothelioma was an asbestos related disease and that workers other than those employed in the dustiest parts of asbestos factories were at risk, were the nature and scale of the hazard reassessed. In Britain, America, and elsewhere new and increasingly strict regulations were enacted.

• Nephrotic syndrome and mesenteric infarction secondary to metastatic mesothelioma. C.K. Farmer, D.J. Goldsmith. 2001;77(907):333-4. Case report PubMed · Publisher · Free full text

  Abstract

  Malignant mesothelioma can present insidiously with progressive breathlessness and chest pain. Paraneoplastic, or non-chest related, presentations are very rare. The case of an elderly man with occupational exposure to asbestos who presented with nephrotic syndrome due to minimal change nephropathy in the context of advanced pleural mesothelial malignancy is reported.

1990s

• Medical research in the Rhondda valleys. H.F. Thomas. 1999;75(883):257-9. Editorial · Historical article PubMed · Publisher · Free full text

  Abstract

  This brief review has highlighted some of the research done by the MRC in the South Wales valleys. The two MRC Units published, in total, over 2000 reports ranging from letters to journals to conference proceedings, with around 200 reports appearing in the BMJ, Lancet and Nature alone. The expertise gained in South Wales meant that the Pneumoconiosis Research Unit team was involved internationally in co-ordinating research on coal workers' lung disease, and later on the health effects of asbestos and other respirable dusts. It is remarkable that the early large-scale studies were conducted and analysed without the benefits of modern computers and statistical packages. The varied Epidemiology Unit research programme enabled Cochrane to develop his ideas on defining health and evaluating health services, and also Elwood, who directed the Unit from 1974 to 1995, to pioneer studies of aspirin prophylaxis in cardiovascular disease. A steady stream of occupational health studies were carried out by Epidemiology Unit staff and many other large surveys were conducted in other parts of South Wales and across the country. Later MRC Epidemiology Unit work has focused on the town of Caerphilly where a prospective study of some 2500 men, established in 1979, has so far resulted in over 100 papers, notably on haemostatic factors related to heart disease. The study has run in tandem with a similar survey in the Speedwell area of Bristol which was established by former Epidemiology Unit staff working for the health authority in that area. Other medical research groups have also worked in the South Wales valleys. In 1961 Julian Tudor Hart left the Epidemiology Unit after a year's research to enter general practice, and establish the famous research practice at Glyncorrwg, over the mountain from the Rhondda Fawr. This year the extensive collection of MRC survey records is being transferred to the Department of Social Medicine at Bristol, and it is quite likely that further research will be undertaken relating Rhondda survey data collected over 40 years ago to subsequent mortality. The South Wales valleys will continue to contribute to medical research into the next millennium. Archie Cochrane's papers have been catalogued and are available for study at the Cochrane Archive established at Llandough Hospital.

• Recurrent pneumothorax following abdominal paracentesis. P.J. Stafford. 1990;66(774):319-20. Case report PubMed · Publisher · Free full text

  Abstract

  A 62 year old man presented with abdominal ascites, without pleural effusion, due to peritoneal mesothelioma. He had chronic obstructive airways disease and a past history of right upper lobectomy for tuberculosis. On two occasions abdominal paracentesis was followed within 72 hours by pneumothorax. This previously unreported complication of abdominal paracentesis may be due to increased diaphragmatic excursion following the procedure and should be considered in patients with preexisting lung disease.

1980s

• Jugular vein thrombosis associated with distant malignancy. B.M. Carrington, J.E. Adams. 1988;64(752):455-8. Case report PubMed · Publisher · Free full text

  Abstract

  We describe two patients who developed internal jugular vein thrombosis associated with primary malignant disease arising outside the neck, and in one patient it was the presenting feature. Computed tomography was performed and the findings characteristic of internal jugular vein thrombosis are illustrated. We conclude that malignant disease should be considered in patients presenting with spontaneous internal jugular vein thrombosis with no other predisposing factors and that computed tomography is of value in confirming the diagnosis.

• Malignant pleural mesothelioma at St Mary's Hospital, Portsmouth--a review of 29 fatal cases. R.N. Harrison, S.C. Hibberd, J.H. Dadds. 1983;59(697):712-6. PubMed · Publisher · Free full text

  Abstract

  The clinical details are presented of 29 fatal cases of pleural mesothelioma in the majority of which there was a history of exposure to asbestos during dockyard work in Portsmouth. Chest pain, breathlessness and weight loss dominated the clinical picture. Analgesia and repeated pleural aspirations provided temporary relief but symptoms invariably progressed. The mean survival time was 39 weeks. Only one patient survived longer than 2 years from hospital presentation. At autopsy, extensive local spread was usual but a high proportion of patients also had metastases at distant sites.

• The role of peritoneal biopsy in the diagnosis of ascites. P.F. Jenkins, M.J. Ward. 1980;56(660):702-3. PubMed · Publisher · Free full text

  Abstract

  Percutaneous biopsies of the peritoneum were obtained in 23 patients with ascites of unknown cause. The only case of tuberculous peritonitis was correctly diagnosed. Peritoneal biopsy provided a diagnosis of malignancy in 6 patients (one lymphoma, one mesothelioma, 4 cases of disseminated carcinoma) but failed to recognize a further 13 cases of disseminated carcinoma. Previous literature is reviewed and the diagnostic usefulness of this procedure is discussed.

1970s

• Malignant mesothelioma invading the spinal canal. D. Cooper. 1974;50(589):718-23. Case report PubMed · Publisher · Free full text

  Abstract

  A case of diffuse malignant pleural mesothelioma presenting as acute paraplegia is described. Autopsy revealed the presence of metastatic tumour within the spinal cord. An alveolar cell carcinoma coexisting with the mesothelioma and giving a distinct histological pattern was also present. There was no histological evidence of asbestos exposure.

1960s

• The epidemiology and clinical features of asbestosis and related diseases. P.C. Elmes. 1966;42(492):623-35. Review PubMed · Publisher · Free full text

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