Toxics

Our medical research library holds 11 studies published in Toxics (2016–2025). Each entry links to the study's record on PubMed and, where there is one, to the publisher's page and a free full text. 11 have an abstract, the authors' own summary as PubMed records it: open "Abstract" to read it.

About the journal

• Publisher: MDPI AG
• Published: 2013 to the present, Switzerland
• Language: English
• ISSN: 2305-6304 (electronic)
• Its record in the NLM Catalog

2020s

• Depressive and Anxiety Symptoms Among Patients with Asbestos-Related Diseases in Korea. M.S. Kang, M.R. Lee, Y. Hwangbo. 2025;13(8). PubMed · Publisher · Free full text

  Abstract

  Asbestos-related diseases (ARDs), including malignant mesothelioma, asbestos-related lung cancer, and asbestosis, are known for their long latency periods and poor prognoses. Although the physical effects of ARDs have been widely studied, limited research has examined the psychological burden faced by affected individuals. This study investigated depressive and anxiety symptoms among 275 patients officially recognized as asbestos victims in Korea. Mental health was assessed using the Korean version of the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and the Hospital Anxiety and Depression Scale (HADS). The analysis revealed that the mean ± standard deviation of depression and anxiety levels among patients with asbestos-related diseases were 8.06 ± 6.27 for PHQ-9, 6.02 ± 5.64 for GAD-7, 7.09 ± 5.44 for HADS-A, and 8.41 ± 5.47 for HADS-D. Patients with asbestosis had higher levels of depressive and anxiety symptoms than those with malignant mesothelioma or lung cancer, with symptom severity increasing alongside asbestosis grade. When compared with national data from the 2020-2021 Korea National Health and Nutrition Examination Survey (KNHANES), PHQ-9 and GAD-7 scores among ARD patients, particularly those with Grade 1 asbestosis, were higher than the scores reported for all major cancer types. These findings highlight the substantial psychological distress experienced by individuals with ARDs and emphasize the urgent need for targeted mental health interventions in this population.

• HMGB1 as a Key Mediator in Malignant Mesothelioma and a Potential Target for Asbestos-Related Cancer Therapy. Y.F. Zhong, C. Ding, C.J. Yao, et al. 2025;13(6). PubMed · Publisher · Free full text

  Abstract

  Malignant mesothelioma (MM) is a highly aggressive cancer strongly associated with asbestos exposure, and accumulating evidence suggests that high mobility group box 1 (HMGB1) plays a central role in its pathogenesis. Our in vitro and in vivo experiments revealed that HMGB1 was highly expressed in MM. Both genetic and pharmacological inhibition of HMGB1 markedly suppressed MM cell viability, migration, and invasion, while inducing G1-phase cell cycle arrest and enhancing apoptosis. Interestingly, the inhibition of Toll-like receptor 4 (TLR4), achieved through both siRNA and TAK-242 treatment, not only suppressed tumor-promoting signals but also reduced HMGB1 expression, suggesting a self-amplifying HMGB1-TLR4 loop. Mechanistically, in vitro experiments indicated that suppression of HMGB1 and TLR4 was associated with decreased activation of NF-κB, AKT, and ERK pathways, which are involved in regulating MM cell survival and motility. In xenograft models, treatment with ethyl pyruvate (EP) and TAK-242 significantly suppressed tumor growth and HMGB1 expression, reinforcing their therapeutic potential. Given HMGB1's influence on both tumor cell behavior and the immune microenvironment, targeting the HMGB1-TLR4 axis may not only provide a novel therapeutic strategy for MM but also offer insights into the mechanisms underlying asbestos-induced tumorigenesis, potentially guiding future prevention and intervention strategies in asbestos-exposed populations.

• Latency Period Among Asbestosis Cases in South Korea by Demographic and Asbestos Exposure Characteristics. W.Y. So, M.S. Kang, Y. Hwangbo, et al. 2025;13(9). PubMed · Publisher · Free full text

  Abstract

  Although asbestos use has been banned in many countries, including South Korea, the long latency period of asbestos-related diseases remains a serious public health concern. We conducted a nationwide, registry-based retrospective study to estimate the latency period of asbestosis and identify its determinants. We analyzed exposure history and demographics for 1110 asbestosis cases collected by the Ministry of Environment and the Environmental Health Center for Asbestos in Korea between 2009 and 2021. Mean latency was 45.3 years for asbestosis Grade 1 and 46.3 years for Grade 2. Patients with occupational exposure had shorter latency than those with environmental exposure: 44.4 vs. 46.0 years in Grade 1 (p = 0.010) and 45.0 vs. 47.0 years in Grade 2 (p < 0.001). Within occupations, production-type work showed the shortest latency; within environmental exposure, residence near asbestos-related industries showed the shortest latency, whereas residence near asbestos mines showed the longest. Longer exposure duration (occupational) was associated with shorter latency, and greater residential distance from the source (environmental) with longer latency. Priorities for further investigation include differences by asbestos fiber type and exposure intensity/modality, to inform strengthened occupational health monitoring and targeted surveillance for residents near industrial sources and legacy mines.

• Wide Riparian Zones Inhibited Trace Element Loss in Mining Wastelands by Reducing Surface Runoff and Trace Elements in Sediment. J. Deng, Z. Li, B. Li, et al. 2024;12(4). PubMed · Publisher · Free full text

  Abstract

  The diffusion of trace elements in mining wastelands has attracted widespread attention in recent years. Vegetation restoration is an effective measure for controlling the surface migration of trace elements. However, there is no field evidence of the effective riparian zone width in mining wastelands. Three widths (5 m, 7.5 m, and 10 m) of Rhododendron simsii/Lolium perenne L. riparian zones were constructed in lead-zinc mining wastelands to investigate the loss of soil, cadmium (Cd), copper (Cu), arsenic (As), lead (Pb), and zinc (Zn). Asbestos tiles were used to cut off connections between adjacent plots to avoid hydrological interference. Plastic pipes and containers were used to collect runoff water. Results showed that more than 90% of trace elements were lost in sediment during low coverage and heavy rainfall periods. Compared with the 5 m riparian zone, the total trace element loss was reduced by 69-85% during the whole observation period in the 10 m riparian zone and by 86-99% during heavy rain periods in the 10 m riparian zone, which was due to reduction in runoff and concentrations of sediment and trace elements in the 10 m riparian zone. Indirect negative effects of riparian zone width on trace element loss through runoff and sediment concentration were found. These results indicated that the wide riparian zone promoted water infiltration, filtered soil particles, and reduced soil erosion and trace element loss. Riparian zones can be used as environmental management measures after mining areas are closed to reduce the spread of environmental risks in mining wastelands, although the long-term effects remain to be determined.

• Asbestos-Environment Pollution Characteristics and Health-Risk Assessment in Typical Asbestos-Mining Area. X. Li, Y. Chen, X. Li, et al. 2023;11(6). PubMed · Publisher · Free full text

  Abstract

  Asbestos has been confirmed as a major pollutant in asbestos-mining areas that are located in western China. In general, asbestos-fibre dust will is released into the environment due to the effect of intensive industrial activities and improper environmental management, such that the health of residents in and around mining areas is jeopardised. A typical asbestos mining area served as an example in this study to analyse the content and fibre morphology of asbestos in soil and air samples in the mining area. The effects of asbestos pollution in and around the mining areas on human health were also assessed based on the U.S. Superfund Risk Assessment Framework in this study. As indicated by the results, different degrees of asbestos pollutions were present in the soil and air, and they were mainly concentrated in the mining area, the ore-dressing area, and the waste pile. The concentration of asbestos in the soil ranged from 0.3% to 91.92%, and the concentration of asbestos fibres in the air reached 0.008-0.145 f·cc-1. The results of the scanning-electron microscope (SEM) energy suggested that the asbestos was primarily strip-shaped, short columnar, and granular, and the asbestos morphology of the soils with higher degrees of pollution exhibited irregular strip-shaped fibre agglomeration. The excess lifetime cancer risk (ELCR) associated with the asbestos fibres in the air of the mining area was at an acceptable level (10-4-10-6), and 40.6% of the monitoring sites were subjected to unacceptable non-carcinogenic risks (HQ > 1). Moreover, the waste pile was the area with the highest non-carcinogenic risk, followed by the ore dressing area, a residential area, and a bare-land area in descending order. In the three scenarios of adult offices or residences in the mining area, adults' outdoor activities in the peripheral residence areas, and children's outdoor activities, the carcinogenic-and non-carcinogenic-risk-control values in the air reached 0.1438, 0.2225 and 0.1540 f·cc-1, and 0.0084, 0.0090 and 0.0090 f·cc-1, respectively. The results of this study will lay a scientific basis for the environmental management and governance of asbestos polluted sites in China.

• Occupational and Environmental Asbestos Exposure and Survival of Patients with Asbestos-Related Cancer: A Follow-Up Study on Patients with Malignant Mesothelioma and Asbestos-Related Lung Cancer in Korea. M.S. Kang, W.R. Chae, Y.J. Lee, et al. 2023;12(1). PubMed · Publisher · Free full text

  Abstract

  Malignant mesothelioma and asbestos-related lung cancer are typically associated with a poor prognosis. However, it has been observed that some patients with these cancers survive significantly longer than the average survival period. While many preliminary studies have investigated factors influencing patient survival, the specific impact of asbestos exposure has not been thoroughly explored. We followed up with 546 patients with malignant mesothelioma and 902 patients with asbestos-related lung cancer, all identified as asbestos victims between 2009 and 2021. In both malignant mesothelioma and asbestos-related lung cancer, patients with occupational asbestos exposure exhibited not only shorter median survival times but also lower 3- and 5-year survival rates compared to those with environmental exposure. Additionally, a longer duration of occupational exposure and closer proximity to the source of asbestos were linked to shorter survival times and lower survival rates. Among the patients with occupational asbestos exposure, the highest hazard ratios (HRs) were observed in those who worked in the production of asbestos-containing products across both cancer types. In contrast, significant HRs were only noted in mesothelioma patients who lived near asbestos industries, slate houses, and redevelopment areas, within the environmentally exposed group.

• An Innovative Filtering System for the Handling of Asbestos-Based Products: Improvement of Safety and Quality of Work in Analysis Laboratories. O. Motta, C. Pironti, M. Venier, et al. 2022;10(6). PubMed · Publisher · Free full text

  Abstract

  Although being banned or restricted in many countries since the early 1990s, large quantities of asbestos are still used or present in building materials all over the world and its removal or handling requires specific systems that limit exposure to airborne fibers The exposure to asbestos causes chronic diseases such as asbestosis and lung cancer with an incubation period of 20 to 50 years. Among the operators most exposed to contamination are those who handle and analyze the materials in laboratories. For this reason, our work focused on an innovative method for removing a filter unit from a laboratory extraction hood, in order to improve the safety conditions for the operators and the surrounding environment. The hood has a particular construction technology with a mechanism that allows the spraying of a special encapsulating liquid on the ULPA filters below the work-bench, which is capable of forming a film and blocking the fibers on the surface of the same filter. The fibers are irreversibly bounded and can no longer be released into the surrounding environment. The monitoring of activity highlighted the absence of asbestos fibers in the air after installation of the filter and workers feel safer performing their activities. The introduction of an innovative filtering system enhanced the safety of work activities involving asbestos exposure, moreover, the time spent on the hood's maintenance and the risk perception of workers were improved.

• Environmental Assessment of Friable Asbestos from Soil to Air Using the Releasable Asbestos Sampler (RAS). P.T. Maulida, J.W. Kim, M.C. Jung. 2022;10(12). PubMed · Publisher · Free full text

  Abstract

  The objectives of this study are to examine the feasibility of the releasable asbestos sampler (RAS) equipment for laboratory tests as an alternative to activity-based sampling (ABS), and to apply the equipment controlled by wind velocity and water contents in the field to asbestos-contaminated soils. Two asbestos-contaminated mines (the Jecheon mine and the Jongmin-ri mine) were selected. At each mine, 21 surface soils (0~15 cm) were sampled, the asbestos concentrations were analyzed, and then three representative sites, containing 0.25%, 0.50%, and 0.75% of asbestos in soils, were chosen to evaluate the amount of releasable asbestos by the modified RAS with wind velocity and water contents. The results showed that the levels of releasable asbestos from soil to air increased with higher wind velocities and lower water content. In addition, the application of risk assessment of releasable asbestos in the soils as an alternative to the activity-based sampling (ABS) method was established at each site, and an estimation of the excess lifetime cancer risk (ELCR) was also calculated. According to the calculation, the estimated ELCR values did not exceed the threshold value (1 × 10-4) in the Jecheon mine for all the soils, while some samples from the Jongmin-ri mine exceeded the threshold value. Therefore, proper remediation work is needed to control friable asbestos from soils to air in the vicinity of the mines.

• Radiation Attenuation Assessment of Serpentinite Rocks from a Geological Perspective. M.A. Masoud, A.M. El-Khayatt, M.G. Shahien, et al. 2022;10(11). PubMed · Publisher · Free full text

  Abstract

  Serpentinites are metamorphic rocks that are widely applied as aggregates in the production of radiation-shielding concrete. Different varieties of massive serpentinite mountains located in Egypt exist without real investment. Hence, this study aims to evaluate the radiation shielding efficacy of three varieties of serpentinite rocks from different geological perspectives: mineralogical, geochemical, and morphological characteristics. X-ray diffraction, transmitted-light microscopy, and thermal analysis were required to characterize their mineralogical composition, while X-ray fluorescence was necessary to investigate their geochemical features. Moreover, scanning electron microscopy was used to detect their morphological characteristics. On the other hand, the PuBe source and stilbene detector were employed for the experimental determination of fast neutrons and γ-ray attenuations, which were conducted at energy ranges of 0.8−11 and 0.4−8.3 MeV, respectively. Based on the mineralogical, geochemical, and morphological characteristics of these rocks, the radiation attenuation capacity of lizardite > antigorite > chrysotile. However, these serpentinites can be applied as a natural alternative to some radiation-shielding concrete in radiotherapy centers and other counterpart facilities.

• Risk of Mortality from Respiratory Malignant and Non-Malignant Diseases among Talc Miners and Millers: A Systematic Review and Meta-Analysis. C. Ciocan, A. Godono, S. Stefanin, et al. 2022;10(10). Review PubMed · Publisher · Free full text

  Abstract

  There is contrasting data on the association between talc exposure and lung and pleural cancer. Given the potential importance of this aspect, we performed a systematic review and meta-analysis to investigate the association between working in the talc extractive industry and mortality from malignant and non-malignant respiratory diseases. We followed PRISMA guidelines to systematically search for pertinent articles in three relevant electronic databases: Pubmed, Scopus, and WebOfScience, from their inception to 30 November 2021. The methodological quality of included articles was evaluated using the US National Institutes of Health tool. Standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs) for malignant and non-malignant respiratory diseases as well as respective 95% confidence intervals (CIs) were extracted or calculated for each included cohort. Six articles comprising 7 cohorts were included in the metanalysis. There was increased mortality for pneumoconiosis, especially in the miner's group (SMR = 7.90, CI 95% 2.77-22.58) and especially in those exposed to higher quartz concentration and for non-malignant respiratory diseases in the overall analysis (SMR = 1.81, CI 95% 1.15-2.82). The risk for lung cancer mortality was slightly increased in the overall analysis (SMR = 1.42, CI 95% 1.07-1.89). The risk for malignant mesothelioma could not be calculated due to an insufficient number of studies assessing this outcome. This systematic review and meta-analysis provides evidence that men working in the talc mining industry have increased mortality for non-malignant respiratory diseases including pneumoconiosis. The small excess in lung cancer mortality may be, in part, explained by the high prevalence of the smokers in some of the analyzed cohorts or by the exposure to other carcinogens like radon decay products and diesel engine exhaust.

2010s

• Current Status of Air Toxics Management and Its Strategies for Controlling Emissions in Taiwan. W.T. Tsai. 2016;4(2). PubMed · Publisher · Free full text

  Abstract

  Since the 1970s, hazardous air pollutants (HAPs), so-called air toxics, have been of great concern because they can cause serious human health effects and have adverse effects on the environment. More noticeably, some of them are known to be human carcinogens. The objective of this paper is to investigate the regulatory systems and human health effects of air toxics which have been designated by the Taiwan government under the Air Pollution Control Act. These toxic air pollutants include acutely toxic gas (i.e., ammonia, chlorine, fluorides, hydrochloric acid, hydrogen cyanide, hydrogen sulfide, nitric acid, phosphoric acid and sulfuric acid), gas containing heavy metals, and carcinogenic chemicals (including formaldehyde, vinyl chloride, asbestos and matter containing asbestos, dioxins and furans, volatile organic compounds, polycyclic aromatic hydrocarbons, and polychlorinated biphenyls). In line with international concern about the carcinogenic risk and environmental persistence of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDDs/PCDFs) and heavy metals in recent years, the current status in monitoring and reducing the emissions of PCDDs/PCDFs from stationary sources was analyzed as a case study in the present study. Furthermore, the control strategies for reducing emissions of air toxics from stationary sources in Taiwan were also addressed.

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