Veterinary Sciences

Our medical research library holds 5 studies published in Veterinary Sciences (2020–2026). Each entry links to the study's record on PubMed and, where there is one, to the publisher's page and a free full text. 5 have an abstract, the authors' own summary as PubMed records it: open "Abstract" to read it.

About the journal

• Publisher: MDPI
• Published: 2014 to the present, Switzerland
• Language: English
• ISSN: 2306-7381 (electronic)
• Its record in the NLM Catalog

2020s

• Chylopericardium in a Dog with Concurrent Chylothorax, Mesothelioma, and Bilateral Brachiocephalic Vein Thrombosis: A Case Report. T. Yoshida, K. Terai, A. Takeuchi, et al. 2026;13(7). Case report PubMed · Publisher · Free full text

  Abstract

  Chylopericardium is an extremely rare disorder in dogs, and its underlying mechanisms and optimal management strategies remain poorly defined. This report describes a dog with chylopericardium complicated by concurrent chylothorax, bilateral brachiocephalic vein thrombosis, and mesothelioma. A 6-year-old neutered male Shiba Inu presented with respiratory distress and was diagnosed with chylothorax and chylopericardium based on fluid analysis. Computed tomography revealed multiple thoracic ducts and bilateral brachiocephalic vein thrombosis but no definitive site of lymphatic leakage. Surgical management included thoracic duct ligation, subtotal pericardiectomy, and cisterna chyli ablation. Histopathological examination of resected pericardial and mediastinal tissues confirmed mesothelioma. Postoperatively, pleural effusion initially decreased but subsequently recurred, and intrathoracic chemotherapy with carboplatin was administered, resulting in long-term control of chylous effusion. Antithrombotic therapy was also initiated for venous thrombosis. The dog remained free of chylous fluid accumulation until death from an unrelated disease. This case highlights the complex interactions among lymphatic, vascular, and neoplastic disorders and suggests that a comprehensive, multimodal diagnostic and therapeutic approach may be effective for managing complicated cases of chylopericardium in dogs.

• Primary Pericardial Well-Differentiated Papillary Mesothelioma in a Spotted Hyena (Crocuta crocuta). L. van der Weyden, D. Keet, N. O'Dell. 2025;12(12). Case report PubMed · Publisher · Free full text

  Abstract

  There have been few reports of neoplasia in hyenas to date. In this report, we describe a captive adult female spotted hyena (Crocuta crocuta) that developed inappetence, lethargy and marked abdominal distension over a 3-day period. The hyena was chemically immobilised to allow clinical investigation of the severe symptoms; however, she died before any internal examination occurred. At necropsy, severe serosanguinous hydropericardium was evident, as well as pulmonary congestion and oedema, ascites and chronic passive congestion of the liver with mild fibrosis. Histopathological examination of the pericardial surface revealed fibrous proliferations lined by mostly a single layer of large proliferating neoplastic mesothelial cells forming papillary projections into the lumen of the pericardial sac as well as infiltration into the pericardial connective tissue, with innumerable haemosiderin-laden macrophages in places, suggestive of chronic haemorrhage. The liver revealed severe congestion and interstitial fibrosis, and the lung revealed congestion and oedema, with moderate numbers of alveolar macrophages and marked anthracosis. The diagnosis was pericardial well-differentiated papillary mesothelioma, with death under anaesthesia caused by cardiogenic shock due to pericardial mesothelioma-associated cardiac tamponade. As primary pericardial mesothelioma (PPM) is a rare tumour type for both animals and humans, and this is the first report of a PPM in a hyena, we compare the clinical findings with those seen in other species.

• Thoracoscopic Assisted PleuralPortTM Application in Seven Dogs Affected by Chronic Pleural Effusion. A. Bianchi, F. Collivignarelli, A. Paolini, et al. 2023;10(5). PubMed · Publisher · Free full text

  Abstract

  Chronic non-septic pleural effusion is a condition that frequently may occur because of lung or pleural neoplasia, or chylothorax refractory to surgical treatment, in dogs. Effusion management can be performed with multiple pleurocenteses or the application of chest drains. New modified vascular devices have been used for patients with chronic diseases; they offer the advantage of allowing home management and do not require hospitalization. Eight PleuralPortTM devices were applied in seven dogs during thoracoscopic exploration and biopsy procedures; five were affected by mesothelioma; one by lung metastases from a mammary carcinoma; and one by chronic chylothorax. The median time of surgical procedure was 51 min; one developed pneumothorax post-operatively that resolved within 12 h after repeated drainage; one device was obstructed after 45 days and was successfully managed by flushing. All patients were discharged after 24 h. The median duration of port insertion in cancer patients was 5 months and those dogs were euthanized because of tumor progression; in the dog with chylothorax, the device was removed after 1 year when the effusion had resolved.

• Pathological Findings of Canine Idiopathic Pericarditis and Pericardial Mesotheliomas: Correlation with Clinical and Survival Data. M. Levi, F. Parenti, L.V. Muscatello, et al. 2021;8(8). PubMed · Publisher · Free full text

  Abstract

  Idiopathic pericarditis (IP) and pericardial mesothelioma (PM) are causes of pericardial effusion in dogs. Pericardiectomy can be a definitive treatment in the case of idiopathic pericardial effusion or a short-term intervention for mesothelioma. The aim of the present study was to investigate which histopathologic parameters are correlated with clinical outcomes in a cohort of dogs that underwent pericardiectomy. The histopathological findings of 22 IPs and 5 PMs were compared with clinical and survival data and the immunohistochemical characterization of immune cells (CD3, CD79α, Iba1). In IP, the mesothelium was lost in 20 cases, reactive in 9, atypical in 3, and mesothelial papillary hyperplasia (MPH) was observed in 4 cases. Numerous macrophages were found in both IPs and PMs especially at the superficial layer of the pericardium. T lymphocytes were observed in mild to moderate numbers and were more numerous than B lymphocytes in both IPs and PMs. MPH was correlated with the quantity of lymphoplasmacytic infiltrate in the superficial layer, inversely related to the thickness of the pericardium, and associated with a longer overall survival. Pericardial fibrosis was present in 19 out of 22 IPs and in all mesotheliomas and was correlated with increased time from initial presentation and pericardiectomy and lymphoplasmacytic infiltrate in the deep zone. Pericardial thickness was correlated with the amount of lymphoplasmacytic and macrophagic infiltrate in the deep zone. Mesothelioma was associated with an increased number of pericardiocentesis procedures before pericardiectomy and with the presence of macrophages in the superficial pericardial layer, edema, fibrin, and hemorrhage. Disease-free interval and overall survival were significantly shorter in patients with mesothelioma compared with IP.

• Spontaneous Tumors and Non-Neoplastic Proliferative Lesions in Pet Degus (Octodon degus). T. Švara, M. Gombač, A. Poli, et al. 2020;7(1). PubMed · Publisher · Free full text

  Abstract

  In recent years, degus (Octodon degus), rodents native to South America, have been becoming increasingly popular as pet animals. Data about neoplastic diseases in this species are still sparse and mainly limited to single-case reports. The aim of this study was to present neoplastic and non-neoplastic proliferative changes in 16/100 pet degus examined at the Veterinary Faculty University of Ljubljana from 2010 to 2015 and to describe the clinic-pathological features of these lesions. Twenty different lesions of the integumentary, musculoskeletal, genitourinary and gastrointestinal systems were diagnosed: amongst these were 13 malignant tumors, six benign tumors, and one non-neoplastic lesion. Cutaneous fibrosarcoma was the most common tumor (7/16 degus). It was detected more often in females (6/7 degus) and lesions were located mainly in hind limbs. The gastrointestinal tract was frequently affected, namely with two malignant neoplasms - an intestinal lymphoma and a mesenteric mesothelioma, four benign tumors - two biliary cystadenomas, an oral squamous papilloma and a hepatocellular adenoma, and a single non-neoplastic proliferative lesion. In one animal, two organic systems were involved in neoplastic lesions.

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