Nephrogenic adenoma of the bladder in children

Our plain-English summary of Nephrogenic adenoma of the bladder in children, by S.R. Nold, W.J. Terry, F.R. Cerniglia, et al (The Journal of Urology, 1989).

The study

• Authors: S.R. Nold, W.J. Terry, F.R. Cerniglia, E.P. Hawkins, D.R. Roth, E.T. Gonzales
• Journal: The Journal of Urology
• Published: 1989;142(6):1545-7
• Type of article: Case report
• Cited by: 13 articles, as counted by NIH iCite
• Read it: PubMed · Publisher

Abstract

Nephrogenic adenoma is an uncommon entity, particularly in children. This benign lesion is believed to represent urothelial transformation in response to trauma or inflammation. Current treatment is local resection with fulguration of the base of the lesion, long-term antimicrobial therapy and periodic cystoscopy. Our 2 cases support not only the urothelial transformation theory but raise the possibility that immunosuppression may be a contributing factor in these lesions.

In plain English

This article reported two cases of nephrogenic adenoma, a benign lesion of the bladder lining, in children less than 10 years old, from Baylor College of Medicine and Texas Children's Hospital in Houston, Texas. It does not concern asbestos. Much of the case histories is unreadable in the scanned text. In case 1, the first lesion developed 5 months after the patient began immunosuppressive therapy, and the patient had no history of trauma or chronic inflammation. In case 2, a child with earlier urinary tract surgery, earlier biopsies first read as cystitis glandularis were found on review to be compatible with nephrogenic adenoma. A 2 by 2.5 cm superficial bladder lesion was removed by partial cystectomy, and many other small papillary lesions were fulgurated (destroyed with electric current). Through the cystoscope, the lesion closely resembled low grade papillary transitional carcinoma. The authors concluded that lesions occurring in immunosuppressed patients, as in case 1, suggest that some might be true adenomas. They added that, until data show a malignant potential, treatment will probably remain endoscopic resection, antibiotics and frequent cystoscopic follow-up.

We wrote this plain-English summary from the full article with the help of AI, and a second AI model checked each sentence against the article. It is not the authors' wording; the abstract and the article are their own account.

What the study did and found

• Design: case report (two cases)
• Who was studied: two children less than 10 years old with nephrogenic adenoma of the bladder, treated at Texas Children's Hospital and Baylor College of Medicine, Houston, Texas
• Exposure: No asbestos exposure is studied. In case 1, the lesion followed immunosuppressive therapy. The article discusses immunosuppression, trauma and chronic inflammation as possible causes of the lesion.
• Main results:
  • Case 1: the initial lesion developed 5 months after immunosuppressive therapy was started, and the patient had no history of trauma or chronic inflammation.
  • Case 2: on review, earlier biopsy specimens that had been read as cystitis glandularis were found compatible with nephrogenic adenoma.
  • Case 2: partial cystectomy removed a 2 X 2.5 cm superficial bladder lesion, and numerous other small papillary lesions throughout the bladder were fulgurated.
  • Case 2: on cystoscopy, the nephrogenic adenoma closely resembled low grade papillary transitional carcinoma.
• The authors' conclusion: The authors concluded that the occurrence of these lesions in immunosuppressed patients, as in their case 1, suggests that at least some might be true adenomas. They also concluded that, until data show a malignant potential, treatment will probably remain endoscopic resection, antibiotic therapy and frequent cystoscopic follow-up.

Topics

The National Library of Medicine indexes this study under subjects our site covers: Mesothelioma.

Medical terms in this study, explained in our Lexicon: Inflammation.

Related studies

• Nephrogenic adenoma: a form of adenomatous metaplasia of the bladder. A clinical and electron microscopical study — E.A. Molland, P.A. Trott, et al. (1976)
• Nephrogenic adenoma of bladder — S.I. Tannenbaum, S.A. Kramer, et al. (1980)
• Nephrogenic adenoma of bladder — E. Kaany, S.L. Werner (1974)
• Nephrogenic metaplasia (adenomatoid tumors) of bladder — J.A. Kaswick, J. Waisman, et al. (1976)
• Occupational cancer of the urinary bladder in dyestuffs operatives and of the lung in asbestos textile workers and iron-ore miners — G.M. Bonser, J.S. Faulds, et al. (1955)
• Environmental and occupational exposures and prognosis in patients with non-muscle-invasive bladder cancer in the Be-Well Study — Z. Wang, M.L. Kwan, et al. (2024)

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