9 results for “General Electric”
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Medical study · Medical research · 2015
Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma
This laboratory study read the protein-coding DNA (the 'exome') of tumors from 22 people diagnosed with malignant pleural mesothelioma at the New York University General Thoracic Surgery Service. Each tumor was compared with the same…
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Medical study · Medical research · 2020
Heterozygous germline BLM mutations increase susceptibility to asbestos and mesothelioma
…Therefore, 7 of 155 apparently unrelated mesothelioma patients carried BLM+/- mutations, significantly higher (P = 6.7E-10) than the expected frequency in a general, unrelated population from the gnomAD database, and 2 of 7 carried…
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Medical study · Medical research · 1986
Contribution of environmental fibers to respiratory cancer
…large. Using a KL of 0.01, the authors estimated fewer than 100 lung cancers and 100 mesotheliomas per year in the general population from past ambient exposures. They noted great uncertainty in these estimates. They…
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Medical study · Medical research · 1999
New molecular and epidemiological issues in mesothelioma: role of SV40
…was difficult to draw conclusions. They suggested that SV40 and asbestos might act together. The authors concluded that it would be premature to reach definitive conclusions about SV40's role in mesothelioma in the general population.
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Medical study · Medical research · 1979
Dose-response relationships for asbestos-related disease: implications for hygiene standards. Part II. Mortality
…first exposure and duration were shown, with gastrointestinal cancer and asbestosis set aside. The author concluded that occupational exposure must be rigorously monitored, but that risk to the general population is likely to be extremely low.
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Medical study · Medical research · 2016
Pleural mesothelioma and lung cancer risks in relation to occupational history and asbestos lung burden
We have conducted a population-based study of pleural mesothelioma patients with occupational histories and measured asbestos lung burdens in occupationally exposed workers and in the general population. The relationship between lung burden and risk, particularly…
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Medical study · Medical research · 2018
Past and current asbestos exposure and future mesothelioma risks in Britain: The Inhaled Particles Study (TIPS)
…lung burdens in British birth cohorts from 1940 to 1992 were estimated for asbestos-exposed workers and the general population. Regression analysis of British mesothelioma death rates and average lung burdens in birth cohorts born before…
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Medical study · Medical research · 2006
Cross reactivity between many anti-human antibodies for their hamster homologs provide the tools to study the signal transduction pathway activated by asbestos and SV40 in the malignant mesothelioma model
…NFkappaB p65, IkappaB, GAPDH) cross-reacted with their hamster counterparts. These data indicate that hamster mesothelioma model and more in general hamster experimental model, can be used for functional studies because many mouse, rabbit, and goat…
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Medical study · Medical research · 2016
Consensus Report of the 2015 Weinman International Conference on Mesothelioma
…as high mobility group box 1 and fibulin-3, are promising. There was general agreement that current treatment for MM, which is based on surgery and standard chemotherapy, has a modest effect on the overall survival…