23 results for “General Electric”, page 1 of 2
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Medical study · Medical research · 2015
Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma
This laboratory study read the protein-coding DNA (the 'exome') of tumors from 22 people diagnosed with malignant pleural mesothelioma at the New York University General Thoracic Surgery Service. Each tumor was compared with the same…
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Medical study · Medical research · 2020
Heterozygous germline BLM mutations increase susceptibility to asbestos and mesothelioma
…Therefore, 7 of 155 apparently unrelated mesothelioma patients carried BLM+/- mutations, significantly higher (P = 6.7E-10) than the expected frequency in a general, unrelated population from the gnomAD database, and 2 of 7 carried…
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Medical study · Medical research · 2022
The association between occupational asbestos exposure with the risk of incidence and mortality from prostate cancer: a systematic review and meta-analysis
…methodological quality appeared to yield elevated SIRs or SMRs. This systematic review and meta-analysis provides evidence that men with occupational asbestos exposure have a PCa incidence and mortality similar to that of the general population…
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Medical study · Medical research · 2023
Occupational asbestos exposure and urinary bladder cancer: a systematic review and meta-analysis
…observed no difference in the subgroup analysis for countries and no direct publication bias evidence. There is evidence that workers with occupational asbestos exposure have a bladder cancer incidence and mortality similar to the general population.
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Medical study · Medical research · 2016
Setting new standards for epidemiological research on mesothelioma
…control study. Controls were resected lung cancer cases, who represent less advanced disease and would be expected to have higher fibre burdens than the general population. Sample retrieval among controls was 262/420 (62.4%). They…
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Medical study · Medical research · 2011
Comparison of exposure assessment methods for occupational carcinogens in a multi-centre lung cancer case-control study
…re-applied to all study subjects. Third, an independent general population JEM (GPJEM) was created by occupational exposure experts not involved in the original study, and applied to study subjects. Results from these methods were compared…
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Medical study · Medical research · 2006
Occupational exposure and laryngeal and hypopharyngeal cancer risk in central and eastern Europe
…For laryngeal cancer, the odds ratio for ever exposure to asbestos in general was 0.86 (95% CI 0.51 to 1.45), and for chrysotile asbestos it was 0.78 (0.44 to 1.40…
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Medical study · Medical research · 2000
Occupational exposures and pancreatic cancer: a meta-analysis
…statistical test showed significant variation between these studies. Twenty populations compared with general-population rates gave a statistically significant ratio of 1.2 (1.0 to 1.5), while four case-control populations gave 0.7…
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Medical study · Medical research · 2003
Estimating exposures in the asphalt industry for an international epidemiological cohort study of cancer risk
…companies enrolled in the cohort, plus the Swedish asphalt paving industry in general. Most companies were engaged in road paving and asphalt mixing, but some also participated in general construction and roofing. Coal tar use was…
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Medical study · Medical research · 2006
Lung fibre burden in lung cancer cases employed in the rock and slag wool industry
…dry lung. Asbestos fibres were found in 16 cases in minor amounts, described by the authors as similar to general-population levels. Lung fibre levels did not follow estimated exposure to MMVF or asbestos, and age…
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Medical study · Medical research · 2010
A case-control study of lung cancer nested in a cohort of European asphalt workers
…risk. A sizable proportion of the excess mortality from lung cancer relative to the general population observed in the earlier cohort phase is likely attributable to high tobacco consumption and possibly to coal tar exposure, whereas…
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Medical study · Medical research · 2014
Occupational and environmental exposures and cancers in developing countries
…The authors concluded that asbestos's health consequences are being underestimated in these countries and that banning asbestos mining, manufacture and general use is imperative. They called their review not exhaustive and noted remaining knowledge gaps.
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Medical study · Medical research · 1999
New molecular and epidemiological issues in mesothelioma: role of SV40
…was difficult to draw conclusions. They suggested that SV40 and asbestos might act together. The authors concluded that it would be premature to reach definitive conclusions about SV40's role in mesothelioma in the general population.
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Medical study · Medical research · 2022
Quantitative Assessment of Asbestos Fibers in Normal and Pathological Pleural Tissue-A Scoping Review
pleural mesothelioma is a rare cancer in the general population, but it is more common in subjects occupationally exposed to asbestos. Studies with asbestos fiber quantification in pleural tissue are scarce: for this reason, we aimed…
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Medical study · Medical research · 2016
Updated mortality study of a cohort of asbestos textile workers
Limited information is available on risk of peritoneal mesothelioma after asbestos exposure, and in general on the risk of cancer after cessation of asbestos exposure. We updated to 2013 the follow-up of a cohort of…
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Medical study · Medical research · 2017
Exposure-Response Analyses of Asbestos and Lung Cancer Subtypes in a Pooled Analysis of Case-Control Studies
…asbestos exposure and assessed the joint effect of asbestos exposure and smoking by sex and lung cancer subtype in general population studies. We pooled 14 case-control studies conducted in 1985-2010 in Europe and Canada…
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Medical study · Medical research · 2016
Mesothelioma among Motor Vehicle Mechanics: An Updated Review and Meta-analysis
…issue, we conducted a new systematic review and meta-analysis. A comprehensive PubMed literature search through May 2014 was conducted to identify studies that reported relative risk estimates for mesothelioma among motor vehicle mechanics (in general)…
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Medical study · Medical research · 2011
Occupational exposure to dusts and risk of renal cell carcinoma
…multi-center, hospital-based renal case-control study. General occupational histories and job-specific questionnaires were reviewed by occupational hygienists for subject-specific information. Odds ratios (ORs) and 95% confidence intervals (95% CIs) between RCC risk…
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Medical study · Medical research · 2006
Cross reactivity between many anti-human antibodies for their hamster homologs provide the tools to study the signal transduction pathway activated by asbestos and SV40 in the malignant mesothelioma model
…NFkappaB p65, IkappaB, GAPDH) cross-reacted with their hamster counterparts. These data indicate that hamster mesothelioma model and more in general hamster experimental model, can be used for functional studies because many mouse, rabbit, and goat…
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Medical study · Medical research · 2024
Lung Cancer Risks Associated with Occupational Exposure to Pairs of Five Lung Carcinogens: Results from a Pooled Analysis of Case-Control Studies (SYNERGY)
…the selected lung carcinogens resulted generally in higher risk than exposure to individual agents, highlighting the importance to reduce and control exposure to carcinogens in workplaces and the general environment. https://doi.org/10.1289/EHP13380.