6 results for “General Electric”
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Medical study · Medical research · 2011
Meeting report: mode(s) of action of asbestos and related mineral fibers
Although asbestos in general is well known to cause a range of neoplastic and non-neoplastic human health effects, not all asbestos fiber types have the same disease-causing potential, and the mode of action (MOA…
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Medical study · Medical research · 2015
Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma
This laboratory study read the protein-coding DNA (the 'exome') of tumors from 22 people diagnosed with malignant pleural mesothelioma at the New York University General Thoracic Surgery Service. Each tumor was compared with the same…
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Medical study · Medical research · 2020
Heterozygous germline BLM mutations increase susceptibility to asbestos and mesothelioma
…Therefore, 7 of 155 apparently unrelated mesothelioma patients carried BLM+/- mutations, significantly higher (P = 6.7E-10) than the expected frequency in a general, unrelated population from the gnomAD database, and 2 of 7 carried…
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Medical study · Medical research · 1999
New molecular and epidemiological issues in mesothelioma: role of SV40
…was difficult to draw conclusions. They suggested that SV40 and asbestos might act together. The authors concluded that it would be premature to reach definitive conclusions about SV40's role in mesothelioma in the general population.
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Medical study · Medical research · 2006
Cross reactivity between many anti-human antibodies for their hamster homologs provide the tools to study the signal transduction pathway activated by asbestos and SV40 in the malignant mesothelioma model
…NFkappaB p65, IkappaB, GAPDH) cross-reacted with their hamster counterparts. These data indicate that hamster mesothelioma model and more in general hamster experimental model, can be used for functional studies because many mouse, rabbit, and goat…
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Medical study · Medical research · 2016
Consensus Report of the 2015 Weinman International Conference on Mesothelioma
…as high mobility group box 1 and fibulin-3, are promising. There was general agreement that current treatment for MM, which is based on surgery and standard chemotherapy, has a modest effect on the overall survival…