561 results for “Reaction Department”, page 27 of 29
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Medical study · Medical research · 1997
Mechanisms of fiber-induced genotoxicity
…during phagocytosis. Secondary molecules that are more stable than ROS are probably involved in DNA damage. Oxidoreduction reactions originating from cells can induce mutations. Genotoxicity is also demonstrated by chromosomal damage associated with impaired mitosis, as…
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Medical study · Medical research · 1997
Cell signaling pathways elicited by asbestos
…integrins. Alternatively, signaling pathways may be stimulated by active oxygen species generated both during phagocytosis of minerals and by redox reactions on the mineral surface. At least two signaling cascades linked to activation of transcription factors…
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Medical study · Medical research · 2005
Respiratory toxicity of multi-wall carbon nanotubes
…inflammation and fibrosis biochemically and histologically. CNT and ground CNT were still present in the lung after 60 days (80% and 40% of the lowest dose) and both induced inflammatory and fibrotic reactions. At 2 months…
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Medical study · Medical research · 1993
Intrapleural recombinant IL-2 in passive immunotherapy for malignant pleural effusion
…treated. The maximum tolerated dose (MTD) of rIL-2, defined as the dose that produced grade 3 or greater toxic reactions in 50 percent of the patients, was 24 x 10(6) IU/m2/d. Although…
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Medical study · Medical research · 1991
The value of anticarcinoembryonic antigen, human milk factor globulin, and antikeratin antibodies in differentiating mesothelioma from lung carcinoma
…some mesotheliomas, reduces the value of the reactions in the individual case. Medical panels adjudicating compensation claims should not use these reactions as the sole criteria in deciding the origin of the tumours in these cases.
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Medical study · Medical research · 1993
Could development of malignant mesothelioma be induced by Yersinia enterocolitica infection?
…pericardiac mesothelioma is an extremely uncommon neoplasm. The possible promotion of malignant mesothelioma by the Yersinia enterocolitica infection should not be disregarded, as the infection may launch chronic immunological reactions resembling those observed among asbestos workers.
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Medical study · Medical research · 1997
Immunolocalization of integrins in the normal lung and in pulmonary carcinomas
…whereas reactions for alpha5 and alpha(v) were weaker and uneven; the remaining integrin subunits were not detected. Bronchial and bronchiolar epithelium showed variably intense staining for alpha2.3,6,v and beta1,4. Reactions were…
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Medical study · Medical research · 2011
Non-neoplastic and neoplastic pleural endpoints following fiber exposure
…diffuse malignant pleural mesothelioma. Translocation and retention of fibers are fundamental processes in understanding the interactions between the dose and dimensions of fibers retained at this anatomic site and the subsequent pathological reactions. The initial interaction…
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Medical study · Medical research · 2012
Experimental results using 3-bromopyruvate in mesothelioma: in vitro and in vivo studies
…of oxygen, a phenomenon referred to as the "Warburg effect", to counteract cancer cell growth. We have tested 3-bromopyruvate (3-BrPA), an inhibitor of pyruvate-associated reactions. Firstly, we tested this agent, in vitro, in…
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Medical study · Medical research · 2007
Imatinib mesylate inhibits fibrogenesis in asbestos-induced interstitial pneumonia
…growth factor receptor (PDGFR) and c-Kit tyrosine kinases, has been shown to inhibit fibrosis and profibrotic signaling in mouse models of inflammation-mediated lung reactions. The authors tested imatinib mesylate in vivo in a mouse…
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Medical study · Medical research · 2010
Analysis on the co-localization of asbestos bodies and Fas or CD163 expression in asbestos lung tissue by in-air micro-pixe
…Ferrous iron, and Magnesium (the components of asbestos) deposition. These results indicate that the system could be useful for investigating the pathogenesis of inhaled particle-induced immune reactions and for determining harmful levels of exogenous agents.
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Medical study · Medical research · 1998
Wollastonite fibers in vitro generate reactive oxygen species able to lyse erythrocytes and activate the complement alternate pathway
…ferric chloride and dithionite. In addition, ROS generation was partially inhibited (by 46-54%) in the reactions performed in the presence of 1,3-dimethyl-2-thiourea (DMTU), a strong hydroxyl radical scavenger. Wollastonite fibers were…
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Medical study · Medical research · 1972
A histochemical study of the asbestos body coating
…after iron extraction were tested by histochemical methods for mucopolysaccharides. The results of the reactions suggest that acid mucopolysaccharides are present in the coating of most bodies. During the formation of the bodies acid mucopolysaccharides might…
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Medical study · Medical research · 1990
The effects of acid precipitation runoff episodes on reservoir and tapwater quality in an Appalachian Mountain water supply
…Several simultaneous reactions were hypothesized to be taking place in the distribution system that involved corrosion of metallic components and coating of asbestos-cement pipe components in part with corrosion products and in part by cations…
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Medical study · Medical research · 1997
Mobilization of iron from urban particulates leads to generation of reactive oxygen species in vitro and induction of ferritin synthesis in human lung epithelial cells
…Urban air particulates also contain iron, and some of the pathological effects after inhalation may be due to reactive oxygen species produced by iron-catalyzed reactions. Two standard reference material (SRM) urban air particulate samples were…
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Medical study · Medical research · 1979
Asbestos-associated disease in employees of Devonport Dockyard
…hyaline plaques were unchanged, and 10% overall progressed to pulmonary fibrosis. Acute pleural reactions were seen in 52 cases. Among 410 men with pleural abnormalities there were 75 deaths in 1967-1976, with an excess of…
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Medical study · Medical research · 2012
NLRP3 promotes inflammation-induced skin cancer but is dispensable for asbestos-induced mesothelioma
…similar incidence of malignant mesothelioma and survival times as wild-type mice. Thus, early inflammatory reactions triggered by asbestos are NLRP3-dependent, but NLRP3 is not critical in the chronic development of asbestos-induced mesothelioma. Notably…
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Medical study · Medical research · 2013
Crystal chemistry of the high temperature product of transformation of cement-asbestos
…for 15 min. After firing, they underwent a series of solid state reactions leading to global structural changes of the matrix. Effects of annealing time and temperature on the crystallization kinetics were thoroughly investigated. Both factors…
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Medical study · Medical research · 2014
Inflammation-related carcinogenesis: current findings in epidemiological trends, causes and mechanisms
…mesotheliomas or lung cancers. These are typical examples of inflammation-related carcinogenesis. It is apparent that the pathogens to induce inflammatory reactions in specific organs are not related to each other. However, the underlying pathogenesis in…
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Medical study · Medical research · 1997
Mineral properties and their contributions to particle toxicity
…that might influence a mineral's biological activity. Several important mineralogical characteristics control a mineral's reactivity in geochemical reactions and are likely to determine its biological reactivity. In addition to the traditionally considered variables of…