145 results for “Reaction Department”, page 7 of 8
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Medical study · Medical research · 1991
Selective differences in macrophage populations and monokine production in resolving pulmonary granuloma and fibrosis
Alveolar macrophages (AM) and their production of interleukin-1-like activity (IL-1) and macrophage-derived growth factor for fibroblasts (MDGF) were examined during chronic inflammatory reactions leading to either granuloma formation or fibrosis. Groups of…
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Medical study · Medical research · 1998
The value of anti-calretinin antibody in the differential diagnosis of normal and reactive mesothelia versus metastatic tumors in effusion cytology
…effusions. Metastatic carcinoma cells were detected with anti-Ber-EP4 in 83% of malignant effusions. Non-specific positive reactions for Ber-EP4 in single mesothelial cells were observed in 16% of all cases and, moreover, frequently…
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Medical study · Medical research · 1997
The role of oxygen free radicals in occupational and environmental lung diseases
…ROS-induced lung injury at different target levels may contribute to similar patterns of cell injury and alterations at the molecular level by initiation, propagation, and autocatalytic chain reactions. Intracellular signalling, activation and inactivation of enzymes…
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Medical study · Medical research · 1992
NHLBI workshop summary. Environmental lung diseases. Relationship between acute inflammatory responses to air pollutants and chronic lung disease
…included microdosimetry of inhaled gases and particles, the transfer of ozone and nitrogen dioxide across the air-tissue interface, oxidative reactions involving nitric oxide, early events leading to lung fibrosis, chronic injury in the proximal alveolar…
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Medical study · Medical research · 1997
Mechanism of asbestos-mediated DNA damage: role of heme and heme proteins
…in the presence of asbestos and hydrogen peroxide/organic peroxide/hydroperoxides. HRP catalyzes oxidation reactions in a manner similar to that of prostaglandin H synthetase. Iron released from asbestos is only partially responsible for DNA damage…
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Medical study · Medical research · 1997
Mechanisms of fiber-induced genotoxicity
…during phagocytosis. Secondary molecules that are more stable than ROS are probably involved in DNA damage. Oxidoreduction reactions originating from cells can induce mutations. Genotoxicity is also demonstrated by chromosomal damage associated with impaired mitosis, as…
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Medical study · Medical research · 1997
Cell signaling pathways elicited by asbestos
…integrins. Alternatively, signaling pathways may be stimulated by active oxygen species generated both during phagocytosis of minerals and by redox reactions on the mineral surface. At least two signaling cascades linked to activation of transcription factors…
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Medical study · Medical research · 1993
Intrapleural recombinant IL-2 in passive immunotherapy for malignant pleural effusion
…treated. The maximum tolerated dose (MTD) of rIL-2, defined as the dose that produced grade 3 or greater toxic reactions in 50 percent of the patients, was 24 x 10(6) IU/m2/d. Although…
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Medical study · Medical research · 1991
The value of anticarcinoembryonic antigen, human milk factor globulin, and antikeratin antibodies in differentiating mesothelioma from lung carcinoma
…some mesotheliomas, reduces the value of the reactions in the individual case. Medical panels adjudicating compensation claims should not use these reactions as the sole criteria in deciding the origin of the tumours in these cases.
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Medical study · Medical research · 1993
Could development of malignant mesothelioma be induced by Yersinia enterocolitica infection?
…pericardiac mesothelioma is an extremely uncommon neoplasm. The possible promotion of malignant mesothelioma by the Yersinia enterocolitica infection should not be disregarded, as the infection may launch chronic immunological reactions resembling those observed among asbestos workers.
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Medical study · Medical research · 1997
Immunolocalization of integrins in the normal lung and in pulmonary carcinomas
…whereas reactions for alpha5 and alpha(v) were weaker and uneven; the remaining integrin subunits were not detected. Bronchial and bronchiolar epithelium showed variably intense staining for alpha2.3,6,v and beta1,4. Reactions were…
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Medical study · Medical research · 1998
Wollastonite fibers in vitro generate reactive oxygen species able to lyse erythrocytes and activate the complement alternate pathway
…ferric chloride and dithionite. In addition, ROS generation was partially inhibited (by 46-54%) in the reactions performed in the presence of 1,3-dimethyl-2-thiourea (DMTU), a strong hydroxyl radical scavenger. Wollastonite fibers were…
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Medical study · Medical research · 1990
The effects of acid precipitation runoff episodes on reservoir and tapwater quality in an Appalachian Mountain water supply
…Several simultaneous reactions were hypothesized to be taking place in the distribution system that involved corrosion of metallic components and coating of asbestos-cement pipe components in part with corrosion products and in part by cations…
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Medical study · Medical research · 1997
Mobilization of iron from urban particulates leads to generation of reactive oxygen species in vitro and induction of ferritin synthesis in human lung epithelial cells
…Urban air particulates also contain iron, and some of the pathological effects after inhalation may be due to reactive oxygen species produced by iron-catalyzed reactions. Two standard reference material (SRM) urban air particulate samples were…
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Medical study · Medical research · 1997
Mineral properties and their contributions to particle toxicity
…that might influence a mineral's biological activity. Several important mineralogical characteristics control a mineral's reactivity in geochemical reactions and are likely to determine its biological reactivity. In addition to the traditionally considered variables of…
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Medical study · Medical research · 1997
Pleural mesotheliomas have an integrin profile distinct from visceral carcinomas
…beta 1 and 4. SMM and the sarcomatoid elements of BMM (scBMM) reacted variably for alpha 1,3,5,6 and v, and beta1. Reactions for alpha3, found in all tumors, were strongest in EMM, ecBMM…
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Medical study · Medical research · 1990
Microsomal lipid peroxidation and oxy-radicals formation are induced by insoluble iron-containing minerals
…two processes are mainly due to the presence of redox active iron at the surface of the solid particles and thus are greatly inhibited by desferrioxamine, a strong iron chelator. However, these reactions are not correlated.
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Medical study · Medical research · 1990
Asbestos and other toxins
…most significant factors in behavioral stability and coping. The author concluded that telling exposed workers the truth about their health appeared to reinforce their usual patterns of behavior rather than create new or non-adaptive reactions.
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Medical study · Medical research · 1998
Occupational illnesses within two national data sets
…sewing machine operators, and dentists. Mental disorders generated more morbidity than is generally acknowledged. Neurotic reactions to stress were highest in the transportation and public utility industries, as well as in finance, insurance, and real estate…
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Medical study · Medical research · 1990
A comparative immunohistochemical study of peritoneal and ovarian serous tumors, and mesotheliomas
…However, since some PST do not stain for any of the three antibodies and the focal nature of positive reactions in some cases may be difficult to interpret, exclusion of mesotheliomas is enhanced by the use…