30 results for “Reaction Department”, page 2 of 2
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Medical study · Medical research · 1997
Efflux of reduced glutathione after exposure of human lung epithelial cells to crocidolite asbestos
…in the same level of intracellular GSH depletion and efflux and the same decrease in gamma-GCS activity as treatment with unmodified crocidolite, which suggests that iron-catalyzed reactions were not responsible for the GSH depletion.
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Medical study · Medical research · 1994
Oxygen radicals and asbestos-mediated disease
Asbestos fibers are potent elaborators of active oxygen species whether by reactions involving iron on the surface of the fiber, or by attempted phagocytosis of fibers by cell types resident in the lung. The link between…
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Medical study · Medical research · 1983
Biochemical components of bronchoalveolar lavage in early experimental asbestosis of the sheep: phospholipase A2 activity, prostaglandin E2 and proteins
…significantly increased in both low and high dose groups. These changes in protein and lipid components of BAL following asbestos exposure constitute early indices of lung inflammatory reactions which may contribute to the development of asbestosis.
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Medical study · Medical research · 1997
The role of oxygen free radicals in occupational and environmental lung diseases
…ROS-induced lung injury at different target levels may contribute to similar patterns of cell injury and alterations at the molecular level by initiation, propagation, and autocatalytic chain reactions. Intracellular signalling, activation and inactivation of enzymes…
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Medical study · Medical research · 1997
Mechanism of asbestos-mediated DNA damage: role of heme and heme proteins
…in the presence of asbestos and hydrogen peroxide/organic peroxide/hydroperoxides. HRP catalyzes oxidation reactions in a manner similar to that of prostaglandin H synthetase. Iron released from asbestos is only partially responsible for DNA damage…
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Medical study · Medical research · 1997
Mechanisms of fiber-induced genotoxicity
…during phagocytosis. Secondary molecules that are more stable than ROS are probably involved in DNA damage. Oxidoreduction reactions originating from cells can induce mutations. Genotoxicity is also demonstrated by chromosomal damage associated with impaired mitosis, as…
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Medical study · Medical research · 1997
Cell signaling pathways elicited by asbestos
…integrins. Alternatively, signaling pathways may be stimulated by active oxygen species generated both during phagocytosis of minerals and by redox reactions on the mineral surface. At least two signaling cascades linked to activation of transcription factors…
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Medical study · Medical research · 1990
The effects of acid precipitation runoff episodes on reservoir and tapwater quality in an Appalachian Mountain water supply
…Several simultaneous reactions were hypothesized to be taking place in the distribution system that involved corrosion of metallic components and coating of asbestos-cement pipe components in part with corrosion products and in part by cations…
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Medical study · Medical research · 1997
Mineral properties and their contributions to particle toxicity
…that might influence a mineral's biological activity. Several important mineralogical characteristics control a mineral's reactivity in geochemical reactions and are likely to determine its biological reactivity. In addition to the traditionally considered variables of…
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Medical study · Medical research · 2000
Inorganic dust pneumonias: the metal-related parenchymal disorders
…of metals, is also discussed. Advances in our knowledge of antigen-specific immunologic reactions in the lung are particularly evident in disorders secondary to beryllium and nickel exposure, where immunologic mechanisms have been well characterized. For…