Analytical and Bioanalytical Chemistry

Our medical research library holds 8 studies published in Analytical and Bioanalytical Chemistry (2003–2025). Each entry links to the study's record on PubMed and, where there is one, to the publisher's page and a free full text. 8 have an abstract, the authors' own summary as PubMed records it: open "Abstract" to read it.

About the journal

• Publisher: Springer-Verlag
• Published: 2002 to the present, Germany
• Language: English
• ISSN: 1618-2642 (print), 1618-2650 (electronic)
• Merged from: Fresenius' Journal of Analytical Chemistry
• Merged from: Analusis
• Merged from: Quimíca Analítica (Belaterra, Spain)
• Absorbed: Chemia Analityczna
• Its record in the NLM Catalog

2020s

• Challenges of analytical methods for the characterization of microsamples from David Alfaro Siqueiros mural painting. A. Mejía-González, Y. Jáidar, P. Aguilar-Rodríguez, et al. 2025;417(1):143-154. PubMed · Publisher · Free full text

  Abstract

  This study presents the analysis of seven microsamples from Untitled Mural 3, painted by David Alfaro Siqueiros between 1964 and 1972. The mural has never been restored, therefore preserving the materials used by the artist. The microsamples were analyzed using a combination of techniques: optical microscopy (OM), scanning electron microscopy with energy-dispersive spectroscopy (SEM-EDS), attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), micro-Fourier transform infrared spectroscopy (micro-FTIR) with reflection mode, and high-resolution nuclear magnetic resonance (NMR) spectroscopy. In this work, compounds common to those identified in the analysis of the contemporary mural Trazos de composición piramidal composition were identified, such as acrylic and nitrocellulose binders, titanium white and iron red oxide as pigments, and DEHP as a plasticizer. Unexpectedly, polyvinyl acetate (PVAc) and different nitrocellulose monomers were identified, in addition to chrome yellow instead of ochre, and a predominance of quartz, asbestos, and talc as fillers, instead of carbonates. The study confirmed that Siqueiros used multiple binders in successive layers in no apparent order, providing valuable insights into his artistic techniques. The research also proved an efficient methodology for studying very small and complex samples.

  © 2024. The Author(s).

2010s

• The role of asbestos morphology on their cellular toxicity: an in vitro 3D Raman/Rayleigh imaging study. S. Yao, H.H. Chen, E. Harte, et al. 2013;405(27):8701-7. PubMed · Publisher

  Abstract

  Amphiboles caused cohorts of deaths in exposed workers, leading to some of the largest class actions in the industry. Once inhaled, these inorganic fibers are thought to be both chemically and morphologically toxic, and their biopersistence in the lungs over decades lead to progressive pathologies, mesothelioma, and asbestosis. However, this exceptionally long chronicity for human pathologies suggests that chemical toxicity is certainly low, suggesting that morphological parameters could be more relevant in the pathology. Here, we developed a 3D Raman/optical imaging methodology in vitro to characterize both morphological and chemical parameters of cell/fiber interactions. We determined that lung cells could vesiculate amphiboles with length below 5 μm or could embed those not exceeding 15 μm in their fibrous extracellular matrix. Lung cells can thus develop defense strategies for handling the biopersistence of inorganic species, which may thus have major impact for biosafety issues related to nanomaterials.

• Iron topochemistry and surface reactivity of amphibole asbestos: relations with in vitro toxicity. A. Pacella, G.B. Andreozzi, J. Fournier, et al. 2012;402(2):871-81. PubMed · Publisher

  Abstract

  Chemical reactivity of asbestos tremolite from Italy and USA localities and Union Internationale Contre le Cancer (UICC) crocidolite was studied in relation to Fe content, oxidation state, and structural coordination. Direct correlation between amount of Fe(2+) at the exposed M(1) and M(2) sites of the amphibole structure and fiber chemical reactivity was established. The in vitro toxicity of the same samples was investigated on human alveolar A549 cell line. Relationship between crystal-chemical features and cell toxicity is not straightforward. UICC crocidolite has Fe content and chemical reactivity largely higher than that of tremolite samples, but all show comparable in vitro toxic potential. Results obtained evidenced that Fe topochemistry is not a primary factor for induced cell toxicity, though it accounts for asbestos chemical reactivity (and possibly genotoxicity).

• Surface chemistry and surface reactivity of fibrous amphiboles that are not regulated as asbestos. M. Fantauzzi, A. Pacella, J. Fournier, et al. 2012;404(3):821-33. PubMed · Publisher

  Abstract

  Three fibrous amphiboles that are not regulated as asbestos--two from Biancavilla (Sicily, Italy) and one from Libby (MT, USA)--were studied in order to establish relationships between surface chemistry and surface reactivity. The three fibrous samples, plus one prismatic fluoro-edenite from Biancavilla that was used for comparison, were investigated by X-ray photoelectron spectroscopy (XPS) in order to obtain their quantitative surface compositions and to determine the chemical environment of the Fe in each case. In particular, the Fe 2p(3/2) peak was fitted and, for the first for these materials, the binding energies of Fe(II) oxide, Fe(III) oxide and Fe(III) oxyhydroxide were identified. Bulk chemistries and Fe oxidation states were obtained from previous studies for the samples from Biancavilla, and were investigated in the present work by electron microprobe (EMP) and (57)Fe Mössbauer spectroscopy (MS) for the sample from Libby. Comparison between surface and bulk data revealed that the sample with the lowest bulk Fe oxidation state was the one most affected by surface oxidation, while the samples with bulk highly-oxidised Fe were showing very high signal of Fe (III) oxy-hydroxide probably due to weathering. The surface reactivities of the fibrous amphiboles were investigated by measuring the production of the [DMPO, HO]• radical adduct using electron paramagnetic resonance (EPR) spectroscopy. Notably, significant chemical reactivity was observed; it was found to be comparable with--or, for the Libby sample, even higher than--that of fibrous tremolite (one of the six asbestos minerals). A positive linear correlation was observed when the production of HO• radical was plotted versus the Fe(II) content on the fibre surface. Data on fibrous tremolite obtained from previous studies were added to substantiate the correlation. These results provide evidence that Fe(II) at the fibre surface controls the production of radicals at the fibre surface. The observed relationship provides further confirmation that Fe topochemistry is strictly related to--though not solely responsible for--the toxicity of asbestos and other fibrous amphiboles that are not regulated as asbestos.

• Analytical characterization of cell-asbestos fiber interactions in lung pathogenesis. S. Yao, G. DellaVentura, C. Petibois. 2010;397(6):2079-89. Review PubMed · Publisher

  Abstract

  Asbestos is a fiber causing lung diseases such as asbestosis and mesothelioma. Although the process involving these diseases remains to be elucidated for developing drugs and treatments, direct consequences of fiber exposure in humans have been clearly demonstrated. These diseases are first characterized by histological heterogeneity and combine chronic inflammation with fibrosis and cellular alterations. As a consequence, asbestosis is usually diagnosed at advanced stages of the disease and treatments are usually inefficient to cure the patients. Here, we review the links established between asbestos fiber chemistry and morphology with the occurrence of associated lung diseases. Cytological and histological aspects of diseases are described with respect to current analytical capabilities, notably for microscopy techniques.

• Chemical characterization of exhaled breath to differentiate between patients with malignant plueral mesothelioma from subjects with similar professional asbestos exposure. G. de Gennaro, S. Dragonieri, F. Longobardi, et al. 2010;398(7-8):3043-50. PubMed · Publisher

  Abstract

  Malignant pleural mesothelioma (MPM) is an aggressive tumour whose main aetiology is the long-term exposure to asbestos fibres. The diagnostic procedure of MPM is difficult and often requires invasive approaches; therefore, it is clinically important to find accurate markers for MPM by new noninvasive methods that may facilitate the diagnostic process and identify patients at an earlier stage. In the present study, the exhaled breath of 13 patients with histology-established diagnosis of MPM, 13 subjects with long-term certified professional exposure to asbestos (EXP) and 13 healthy subjects without exposure to asbestos (healthy controls, HC) were analysed. An analytical procedure to determine volatile organic compounds by sampling of air on a bed of solid sorbent and thermal desorption GC-MS analysis was developed in order to identify the compounds capable of discriminating among the three groups. The application of univariate (ANOVA) and multivariate statistical treatments (PCA, DFA and CP-ANN) showed that cyclopentane and cyclohexane were the dominant variables able to discriminate among the three groups. In particular, it was found that cyclohexane is the only compound able to differentiate the MPM group from the other two; therefore, it can be a possible marker of MPM. Cyclopentane is the dominant compound in the discrimination between EXP and the other groups (MPM and HC); then, it can be considered a good indicator for long-term asbestos exposure. This result suggests the need to perform frequent and thorough investigations on people exposed to asbestos in order to constantly monitor their state of health or possibly to study the evolution of disease over time.

• Combined use of X-ray photoelectron and Mössbauer spectroscopic techniques in the analytical characterization of iron oxidation state in amphibole asbestos. M. Fantauzzi, A. Pacella, D. Atzei, et al. 2010;396(8):2889-98. PubMed · Publisher

  Abstract

  Asbestos fibers are an important cause of serious health problems and respiratory diseases. The presence, structural coordination, and oxidation state of iron at the fiber surface are potentially important for the biological effects of asbestos because iron can catalyze the Haber-Weiss reaction, generating the reactive oxygen species *OH. Literature results indicate that the surface concentration of Fe(III) may play an important role in fiber-related radical formation. Amphibole asbestos were analyzed by X-ray photoelectron spectroscopy (XPS) and Mössbauer spectroscopy, with the aim of determining the surface vs. bulk Fe(III)/Fe(tot) ratios. A standard reference asbestos (Union Internationale Contre le Cancer crocidolite from South Africa) and three fibrous tremolite samples (from Italy and USA) were investigated. In addition to the Mössbauer spectroscopy study of bulk Fe(III)/Fe(tot) ratios, much work was dedicated to the interpretation of the XPS Fe2p signal and to the quantification of surface Fe(III)/Fe(tot) ratios. Results confirmed the importance of surface properties because this showed that fiber surfaces are always more oxidized than the bulk and that Fe(III) is present as oxide and oxyhydroxide species. Notably, the highest difference of surface/bulk Fe oxidation was found for San Mango tremolite--the sample that in preliminary cytotoxicity tests (MTT assay) had revealed a cell mortality delayed with respect to the other samples.

2000s

• Determination of low levels of free fibres of chrysotile in contaminated soils by X-ray diffraction and FTIR spectroscopy. E. Foresti, M. Gazzano, A.F. Gualtieri, et al. 2003;376(5):653-8. PubMed · Publisher

  Abstract

  A new analytical method for the determination of low levels (0.01-1 wt%) of free fibres of chrysotile in contaminated clayey, sandy and sandy-organic soils is described. The detection limit of 0.01 wt% is reached with an enrichment of free fibres of chrysotile in the sample using a standard laboratory elutriator for sedimentation analysis. The chrysotile quantitative determination is performed both by X-ray powder diffraction, using the internal standard and reference intensity ratio methods, and by Fourier-transform infrared absorption spectroscopy. The procedure can be successfully applied to different soils after removal, by a thermal treatment, of the matrix components which can interfere. This straightforward method fulfils the request of public institutions and private companies for an appropriate quantitative determination of chrysotile-free fibres in contaminated soils.

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