APMIS

Our medical research library holds 15 studies published in APMIS (1988–2025). Each entry links to the study's record on PubMed and, where there is one, to the publisher's page and a free full text. 13 have an abstract, the authors' own summary as PubMed records it: open "Abstract" to read it. For 1 study PubMed has no abstract for, we give the abstract printed in the article or, where there is none, a summary we wrote from it, each labeled as such.

About the journal

• Publisher: Munksgaard
• Published: 1988 to the present, Denmark
• Language: English
• ISSN: 0903-4641 (print), 1600-0463 (electronic)
• Merged from: Acta Pathologica, Microbiologica, et Immunologica Scandinavica. Section A, Pathology
• Merged from: Acta Pathologica, Microbiologica, et Immunologica Scandinavica. Section B, Microbiology
• Merged from: Acta Pathologica, Microbiologica, et Immunologica Scandinavica. Section C, Immunology
• Absorbed: APMIS. Supplementum
• Its record in the NLM Catalog

2020s

• An Evaluation Into the Robustness of Grading of Pleural Mesothelioma Outside of Specialist Centres. S. Prabhakaran, A.J. Hocking, Y. Irani, et al. 2025;133(3):e70006. PubMed · Publisher · Free full text

  Abstract

  The 2021 WHO classification of thoracic tumours recommends grading pleural mesothelioma to aid prognostication. Robustness of grading and morphological characterisation is key to its clinical utility, though validation of this grading system has largely been conducted by expert thoracic pathologists. We conducted a survey inviting pathologists across a range of practices and expertise to grade digitised images of 50 epithelioid pleural mesotheliomas that had been graded by an expert in thoracic pathology. We included slides that were considered potentially problematic such as small biopsies, focal necrosis, and rare subtypes that may affect grading (small cell and deciduoid features). Using the Sectra Uniview web viewer, participants were asked to score atypia, mitotic count, and necrosis and choose from a list of cytological and architectural features. Seventy-four pathologists anonymously participated. There was 90% agreement of consensus scores with expert opinion using the WHO 2-tier grade and 72% for the 3-tier nuclear grade but only 70% for nuclear atypia, 56% for mitoses, and 84% for necrosis. Both 3-tier nuclear grade and WHO 2-tier grading systems were significantly associated with survival. Our study affirms the overall robustness and utility of grading for pleural mesothelioma, reveals variances, and suggests the need for dedicated training.

  © 2025 The Author(s). APMIS published by John Wiley & Sons Ltd on behalf of Scandinavian Societies for Pathology, Medical Microbiology and Immunology.

• Mediastinal and pleuropulmonary myeloid sarcoma with HBME1 and podoplanin expression. A diagnostic pitfall. D. Suárez-Vilela, F.M. Izquierdo. 2020;128(1):65-68. Case report · Letter PubMed · Publisher

2010s

• Pseudomesotheliomatous carcinoma of the pleura: an autopsy case of metastasis from a G-CSF-producing anaplastic carcinoma of the pancreas. Y. Hattori, K. Sentani, T. Hattori, et al. 2018;126(2):166-170. Case report PubMed · Publisher

  Abstract

  Pseudomesotheliomatous carcinoma is a malignant tumor that extends along the pleura mimicking malignant mesothelioma. An 81-year-old male patient presented to our hospital with epigastralgia, and abdominal computed tomography (CT) showed a 36-mm tumor in the pancreatic tail. The laboratory data revealed a high leukocyte count (>44 000/μL). Chest CT showed left pleural thickening with pleural effusion. The cancer showed a poor response to chemotherapy, and the patient died of respiratory failure at 5 months after the onset of disease. Autopsy showed solid tumor with hemorrhage, measuring 6 cm in diameter, in the pancreatic tail, with wide invasion to the stomach, left adrenal gland, spleen, and diaphragm. The left pleura, which was circumferentially thickened by the involved tumor, macroscopically resembled pleural mesothelioma. Histologically, the primary pancreatic tumor was diagnosed as anaplastic carcinoma, due to the absence of glandular structures or other features that would indicate a definite direction of differentiation. The primary lesion and carcinoma involving the left pleura were all positive for G-CSF. We recently experienced an autopsy case of G-CSF-producing anaplastic carcinoma with pseudomesotheliomatous spread.

  © 2017 APMIS. Published by John Wiley & Sons Ltd.

• Incidental finding of multiple well-differentiated papillary mesotheliomas in peritoneum. M. Jakobsen, B. Engvad, T. Jensen, et al. 2016;124(4):333-4. Case report PubMed · Publisher

  Abstract

  We present a case of multiple well-differentiated papillary mesotheliomas (WDPM) in the peritoneum found incidentally in a 63-year-old man with urothelial carcinoma of the bladder. When multiple tumors are seen, malignant mesothelioma should be excluded by histopathological examination as this may have a similar focal appearance to WDPM. True stromal invasion is by far the most reliable criterion of mesothelial malignancy. In doubtful cases, a conservative diagnostic approach has been recommended. Compared to malignant mesotheliomas, WDPMs are rare and have a relatively indolent clinical course with a good prognosis. Great care is needed when diagnosing mesothelial proliferations, given the crucial nature of a benign vs malignant diagnosis. No standardized treatment has yet been established.

  © 2016 APMIS. Published by John Wiley & Sons Ltd.

• Expression of snail, twist, and Zeb1 in malignant mesothelioma. H. Merikallio, P. Pääkkö, K. Salmenkivi, et al. 2013;121(1):1-10. PubMed · Publisher

  Abstract

  We examined 56 malignant mesotheliomas, 117 lung adenocarcinomas, and 34 metastatic lung adenocarcinomas with antibodies to transcription factors involved in epitheliomesenchymal transition. The tumors were stained immunohistochemically with antibodies zeb1, twist, and snail. Malignant mesotheliomas exhibited a stronger expression of zeb1 and twist than lung adenocarcinomas (p < 0.001 for both). Metastatic adenocarcinomas displayed a more frequent expression of zeb1 and twist (p < 0.001 for both) than lung adenocarcinomas. Patients with snail positive mesotheliomas experienced a better survival (p = 0.046), whereas in lung adenocarcinomas, this trait predicted worse survival (p = 0.024). Biphasic mesotheliomas had a more frequent expression of snail or zeb1 than epithelioid and sarcomatoid mesotheliomas as a group (p = 0.034 and p = 0.005, respectively). E-cadherin was more commonly present in epithelioid mesotheliomas (p = 0.002). Cases with snail positivity showed a significantly lower apoptotic index (p = 0.039). Malignant mesotheliomas display strong twist and zeb1 expression, which may be an indication of transdifferentiation between the epithelioid and sarcomatoid cell types with biphasic mesotheliomas representing tumors in active transition. Metastatic adenocarcinomas show a higher expression of zeb1 and twist than primary lung tumors, confirming our previous findings and highlighting their significance in the metastatic process. Snail expression is associated with poor prognosis in lung adenocarcinomas, but an opposite effect was seen in mesothelioma, a fact which may be related to the different cellular origin of epithelial and mesothelial cells.

  © 2012 The Authors APMIS © 2012 APMIS.

• Are differentially expressed microRNAs useful in the diagnostics of malignant pleural mesothelioma?. M. Andersen, M. Grauslund, M. Muhammad-Ali, et al. 2012;120(9):767-9. Letter PubMed · Publisher

  Summary

  This letter asked whether four microRNAs (miR-17-5p, miR-30c, miR-221 and miR-222), previously reported in studies of mesothelioma subtypes or cell lines, could help distinguish malignant pleural mesothelioma (MPM) from reactive mesothelial proliferations. The authors, from Rigshospitalet, Copenhagen University Hospital, Denmark, measured these microRNAs by real-time PCR (TaqMan assays, normalized to RNU6B). They used formalin-fixed paraffin-embedded epithelioid MPM tissue (stages I-IV) and adjacent non-neoplastic pleura from 13 patients (11 men, 2 women). The patients had extra-pleural pneumonectomy after 1-3 cycles of chemotherapy. Compared with non-neoplastic pleura, MPM showed significant down-regulation of miR-17-5p and up-regulation of miR-221. MiR-30c and miR-222 were not differentially expressed. The patterns for miR-17-5p and miR-221 were opposite to those previously reported in MPM cell lines. To check whether pre-surgical chemotherapy explained the findings, the authors compared surgical samples with diagnostic biopsies taken before any treatment, in six matched patients and in six further patients, and found no significant differences. Receiver-operating-characteristic analysis for miR-17-5p and miR-221 gave areas under the curve below 0.8 with p > 0.05, so the International Mesothelioma Interest Group criteria for a suitable marker were not met. The authors concluded that these microRNAs may not be suitable diagnostic markers for differentiating MPM from reactive proliferations, that this requires corroboration in a larger set of samples, and that a broad screen of microRNA expression in surgical MPM and non-neoplastic pleura samples is needed.

  PubMed has no abstract for this study, and the article doesn't print one. We wrote this summary from the full article with the help of AI. It is not the authors' wording.

2000s

• Localized malignant mesothelioma of the epithelial type occurring as a primary hepatic neoplasm: a case report with review of the literature. J. Imura, K. Ichikawa, J. Takeda, et al. 2002;110(11):789-94. Case report PubMed · Publisher

  Abstract

  We report a localized malignant mesothelioma of the epithelial type, occurring as a primary hepatic neoplasm in a 64-year-old male. He was found to have a mass located in the right lobe of the liver. Surgery was carried out with resection of the mass from the right hepatic lobe, with partial resection of the diaphragm. Grossly, an ill-defined tumor was present in the hepatic parenchyma. Histologically, the tumor displayed a predominant tubular pattern of growth with a desmoplastic stroma. The tubules were lined by a single layer of cuboidal or flattened cells with pleomorphic vesicular nuclei. A hyaluronidase-digestible, mucin-like substance was demonstrated in the lumen and tumor cytoplasm. The tumor cells were immunohistochemically positive for calretinin, HBME-1, cytokeratin, i.e. AE1/AE3 and CAM 5.2, but negative for carcinoembryonic antigen, CD 34 and Leu M1. Moreover, the tumor cells showed nuclear accumulation of the p53 oncopotein and reacted frequently with Ki-67 antibody. These findings support the concept that malignant mesothelioma of the epithelial type may occur at extrapleural sites. To the best of our knowledge, this is the first reported case of localized malignant primary mesothelioma arising in the liver.

1990s

• Effect of insulin and epidermal growth factors on the synthesis of glycosaminoglycans/proteoglycans in cultured human malignant mesothelioma cells of different phenotypic morphology. G.N. Tzanakakis, N.K. Karamanos, A. Syrokou, et al. 1996;104(10):718-28. PubMed · Publisher

  Abstract

  Two human malignant mesothelioma cell sublines, one with a fibroblast-like and the other with an epithelial differentiation, were examined for their capacity to synthesize glycosaminoglycans in the presence of IGF-I, EGF, and their combination. This synthesis depends on the morphology of the mesothelioma cells, with many-fold higher amounts of both hyaluronan and proteoglycans being produced by the cells with epithelial morphology than by those of the fibroblast phenotype. In both cell lines this synthesis was affected in a dose-dependent fashion by the exogenously added growth factors and exposure to IGF-I and EGF in combination showed a synergistic effect. This effect of those factors seems to be mediated via protein tyrosin kinase-dependent receptors and was different in the fibroblast-like and epithelial cells. The synthetic rates of the various glycosaminoglycans formed (hyaluronan, galactosaminoglycans and heparan sulfate) were also variously affected by these factors, indicating differences in how the synthesis of the various glycosaminoglycans is regulated. The results obtained suggest a close correlation between the presence of the appropriate growth factor(s), the process of cell differentiation and the synthesis of glycosaminoglycans in these cells.

• A synergistic interaction between Bacillus Calmette-Guérin (BCG) and NADPH oxidase stimulants on the production of reactive oxygen metabolites by human mononuclear phagocytes. P.W. Nyberg, S.A. Nordman, L. Linko. 1994;102(1):67-71. PubMed · Publisher

  Abstract

  Bacillus Calmette-Guérin (BCG) was added simultaneously with known NADPH oxidase stimulants to suspensions of human mononuclear leukocytes, and the subsequent production of reactive oxygen metabolites (ROMs) was studied by luminol-dependent chemiluminescence. BCG significantly amplified the ROM responses induced by zymosan, phorbol myristate acetate (PMA), and quartz, but not by concanavalin A and asbestos fibers. The stimulatory effect occurred rapidly when BCG was added to cells already phagocytosing zymosan, and vanished rapidly when extracellular BCG was removed from adherent monocyte cultures by washing prior to the addition of zymosan. The stimulatory effect of BCG could not be reproduced with recombinant interferon-gamma, tuberculin PPD, muramyl dipeptide, nor with the apathogenic Mycobacterium tuberculosis strain RV37. BCG and zymosan or PMA that had been incubated together prior to addition to the mononuclear cell suspensions caused ROM production with faster kinetics than if the reagents were added separately without preincubation. In conclusion, the synergy between BCG and some of the NADPH oxidase stimulants seems to be due to an interaction between BCG and the NADPH oxidase stimulants rather than to an interaction between BCG and the ROM-producing cells. Such interactions between mycobacteria and NADPH oxidase stimulants may be of importance as a factor affecting the individual susceptibility to tissue damage in tuberculosis, for example in silicotuberculosis.

• Immunohistochemical reactivity in mesothelioma and adenocarcinoma: a stepwise logistic regression analysis. A. Dejmek, A. Hjerpe. 1994;102(4):255-64. PubMed · Publisher

  Abstract

  Histological sections from 103 malignant mesotheliomas and 43 adenocarcinoma metastases in pleural biopsies were investigated for reactivity against a panel of 11 different antibodies. The size of the material allowed the evaluation by stepwise logistic regression analysis, which selected five parameters of major importance: vimentin reactivity in epithelial cells, reactivity to low-molecular-weight keratins in fibrous cells, strong membrane accentuation of EMA reactivity, and lack of reactivity to LeuM1 and BerEp4. Three of these criteria were sufficient to identify a mesothelioma with high specificity and with a sensitivity of approximately 70%. Whilst the monoclonal anti-CEA tested was the most valuable single parameter, it did not add any diagnostic information to the combination of criteria selected by the stepwise logistic regression analysis. However, this antibody can be used to exclude most of the adenocarcinomas from further analysis with the more extensive panel.

• Increased mineral dust-induced production of reactive oxygen species by blood monocytes from patients with malignant diseases. P.W. Nyberg, S.A. Nordman, M.L. Klockars. 1994;102(10):765-70. PubMed · Publisher

  Abstract

  Mononuclear leukocytes were isolated from the peripheral blood of 15 patients with malignant pulmonary diseases, 17 patients with pulmonary infections, 18 patients with chest film abnormalities of non-malignant, non-infectious etiology, and 15 healthy persons. The cells were exposed to zymosan yeast, BCG vaccine, quartz, or chrysotile asbestos, and the subsequent production of reactive oxygen species (ROS) was measured by luminol-dependent chemiluminescence. All the stimulants caused significantly higher ROS production in the patient groups than in the healthy control group, and the asbestos-induced ROS production was significantly more pronounced in the cancer group than in the two non-cancer patient groups combined. After one-year follow-up, 5 of the 15 cancer patients were alive, and these patients had significantly lower mineral dust-induced ROS responses at the time of diagnosis than were found in the patients who died. This result was verified in a subsequent study comprising 19 patients with malignant pulmonary disorders (6 alive after one year). In conclusion, monocytes from patients with malignant diseases seem to be primed for an increased ROS production, and high ROS responses seem to correlate with a poor one-year survival of the patients.

• Immunohistochemical study of 158 lung carcinomas. L. Johansson, C. Andersson, M. Albin. 1992;100(10):914-21. PubMed · Publisher

  Abstract

  Lung carcinomas were studied immunohistochemically and the results were related to type of tissue sample (bronchoscopic biopsies, surgical specimens, autopsies). All cytokeratins (CAM 5.2, PKK-1, AE1/AE3) reacted with virtually all adenocarcinomas, most squamous, and 65% of the large cell carcinomas, while CAM 5.2 was most efficient with the small cell carcinomas. CEA stained 33% and 60% of the small and large cell carcinomas, respectively, most adenocarcinomas, and 84% of the squamous cell carcinomas, among which staining decreased with dedifferentiation and was often focal. EMA reacted with 90%, and NSE with 20% of all histological types. There was no staining for NF. All antibodies, except EMA, were more efficient with surgical specimens. Our study implies that the cytokeratins we used work better with surgical material, but are generally comparable to monospecific cytokeratin antibodies. Also, EMA is a reliable marker for epithelial differentiation with all types of tissue samples. Moreover, CEA negativity in several poorly differentiated lung carcinomas might have implications in the differential diagnosis against pleural mesothelioma.

1980s

• Diagnostic value of monoclonal antibody B72.3 in detecting adenocarcinoma cells in serous effusions. A.F. Lauritzen. 1989;97(8):761-6. PubMed · Publisher

  Abstract

  In serous effusions, the cytologic diagnosis of adenocarcinoma, and its distinction from mesothelial hyperplasia and malignant mesothelioma, is still difficult. This study compares the immunoreactivity of antibody B72.3 with that of anti-CEA, anti-LeuM1-antigen and anti-keratins in 41 serous effusions from patients with different malignant disorders. B72.3 selectively stained adenocarcinoma cells in 80% of the cases and was as good as anti-CEA and superior to anti-LeuM1-antigen and anti-keratins. It is concluded that B72.3 forms a useful supplement to conventional cytomorphology in the distinction between adenocarcinoma cells, reactive mesothelial cells and malignant mesothelial cells in serous effusions.

• Trends in cardiac metastasis. B. Karwinski, E. Svendsen. 1989;97(11):1018-24. PubMed · Publisher

  Abstract

  A review of 8571 autopsies disclosed 2833 patients with malignant tumours from 1975 to 1984 at the Department of Pathology, The Gade Institute. Cardiac metastases were found in 130 cases. An increase of cardiac involvement was shown in the autopsy material from 1.2% in 1975-1979 to 1.8% in 1980-1984. The same trend was seen if cardiac metastases were related to malignant tumours. Numerically, lung cancer accounted for most of the metastases seen, but the increase was made up by other tumours than lung cancer. especially malignant melanoma, mesothelioma, breast cancer and sarcomas. These tumours have a high frequency of heart metastases and the increased incidence of these cancers in the material explains the rise of cardiac metastases. Cardiac metastases increased with rising number of distant metastases. This study shows that mesotheliomas have the highest percentage of cardiac spread. The importance of autopsy for detecting metastatic spread in sites that are difficult to detect clinically is emphasized.

• Peritoneal, benign, cystic mesothelioma with free-floating cysts, re-examined by new methods. A case report. O.H. Iversen, T. Hovig, P. Brandtzaeg. 1988;96(2):123-7. Case report PubMed · Publisher

  Abstract

  A histologically-confirmed, multicystic, benign mesothelioma, with free-floating, thin-walled cysts, in the abdominal cavity of a 27-year-old woman was reported in 1954. After removal of all visible cysts by laparotomy, the patient was healthy and well for 29 years, when she was surgically treated for cholecystitis and gall bladder stones in 1982. The whole peritoneum was found covered with small cysts lined by mesothelial cells. The patient is (April 1987) well, with no complaints. Sections from the old paraffin blocks were studied by means of scanning, transmission electron microscopy and immunohistochemistry. These methods confirmed the histological diagnosis. The authors discuss whether such a lesion really is a benign tumor or should rather be otherwise classified.

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