In Vivo

Our medical research library holds 6 studies published in In Vivo (2006–2026). Each entry links to the study's record on PubMed and, where there is one, to the publisher's page and a free full text. 6 have an abstract, the authors' own summary as PubMed records it: open "Abstract" to read it.

About the journal

• Publisher: International Institute of Anticancer Research
• Published: 1987 to the present, Greece
• Language: English
• ISSN: 0258-851X (print), 1791-7549 (electronic)
• Its record in the NLM Catalog

2020s

• Impact of CD73/CD155 Expression on Survival in Resected Epithelial Pleural Mesothelioma: A Retrospective Single-center Study. Y. Nabe, Y. Fujita, T. Hashimoto, et al. 2026;40(4):2204-2224. PubMed · Publisher · Free full text

  Abstract

  Background/Aim: While CD73 and CD155 are implicated in immune evasion and tumor progression, their roles in pleural mesothelioma (PM) remain unclear. Therefore, we investigated the association between CD73 and CD155 expression in resected epithelial PM specimens and explored their impact on 5-year progression-free survival (PFS) and 5-year overall survival (OS).

  Patients And Methods: This single-center retrospective study enrolled 43 patients with epithelial PM who underwent curative-intent surgery, with/without chemotherapy and immune checkpoint inhibitor (ICI) treatment, between January 2013 and December 2020. HALO-AI pathology software was used to quantify CD73 and CD155 expression following immunohistochemical staining. Cutoff values for CD73/CD155 positivity were determined using receiver operating characteristic curves. Patients were categorized into CD73+/CD155+ and non-CD73+/CD155+ groups, and survival outcomes were analyzed using Kaplan-Meier curves and Cox proportional hazards regression.

  Results: Among 35 cases, patients with CD73+/CD155+ tumors exhibited significantly improved 5-year PFS compared with those with non-CD73+/CD155+ tumors (64.8% vs. 10.8%, p=0.017); however, OS differences were not significant (p=0.376). Among CD73+/CD155+ cases, postoperative pleurodesis with OK432 was associated with improved PFS (83.3% vs. 33.3%, p=0.03). Among non-CD73+/CD155+ cases, postoperative chemotherapy significantly improved PFS (p<0.001). Univariate analysis identified non-CD73+/CD155+ expression as an independent predictor of disease progression [hazard ratio (HR)=0.2546, p=0.02933]. Among recurrent cases, patients treated with ICIs exhibited significantly improved OS (p=0.001), highlighting the potential of immunotherapy.

  Conclusion: CD155 may serve as a poor prognostic factor in mesothelioma and represents the first immunohistochemical evaluation of this marker. Although CD73 and CD155 co-expression were initially predicted to indicate poor prognosis, findings were unexpected, likely due to inability to establish an optimal cutoff value given variations in patient demographics, disease stage, and treatment approaches.

  Copyright © 2026, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

• Asbestos Exposure and Leukemia Incidence: A Systematic Review and Meta-analysis. K. Dodos, T.V. Kalamara, P. Papalexis, et al. 2025;39(5):2739-2751. Systematic review · Meta-analysis PubMed · Publisher · Free full text

  Abstract

  Background/Aim: Asbestos comprises six naturally occurring fibrous minerals known for their health risks, particularly in occupational settings. This systematic review evaluates the association between asbestos exposure and leukemia incidence, synthesizing findings from various studies.

  Materials And Methods: We conducted a comprehensive literature search in PubMed, Cochrane Library, and Web of Science, adhering to PRISMA guidelines. Studies included participants exposed to asbestos compared to matched controls, focusing on leukemia incidence. Data extraction and quality assessment were performed using the Newcastle-Ottawa Scale.

  Results: A total of 1,751,580 participants were included, with 257,572 (14.7%) exposed to asbestos. The incidence of leukemia varied across studies, ranging from 0.02% to 0.45%. Meta-analysis revealed an overall risk ratio of 1.25 (95% confidence interval=0.81-1.94) with significant heterogeneity (I2=86%), indicating no statistically significant difference between exposed and non-exposed cohorts.

  Conclusion: The findings highlight the complexity of the relationship between asbestos exposure and leukemia, influenced by factors such as exposure type, duration, and confounding variables like smoking. While some studies suggest a potential link, the evidence remains inconclusive, necessitating further research. This review underscores the need for high-quality studies to clarify the association between asbestos and leukemia, informing public health policies to reduce exposure risks and protect vulnerable populations.

  Copyright © 2025, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

2010s

• Clinicopathological Characteristics of Well-differentiated Papillary Mesothelioma of The Peritoneum: A Single-institutional Experience of 12 Cases. M. Kim, H.S. Kim. 2019;33(2):633-642. PubMed · Publisher · Free full text

  Abstract

  Background/Aim: Well-differentiated papillary mesothelioma (WDPM) is histologically characterized by papillary architecture with fibrovascular cores, lined by bland mesothelial cells. We recently experienced a case of WDPM associated with multiple peritoneal inclusion cysts, which prompted us to initiate a comprehensive review of previously diagnosed WDPM cases.

  Materials And Methods: The clinicopathological characteristics and immunophenotype of 12 cases of peritoneal WDPM were investigated using a review of electronic medical records, pathological examination, and immunostaining.

  Results: The patients' ages ranged from 23 to 75 years. No patient had endometriosis or a previous history of asbestos exposure. Ten tumors were detected incidentally during surgery for other causes. Most tumors appeared as a small, single nodule on the peritoneal surface, but in three cases, WDPM presented as multiple lesions. All but one patient had no symptoms. All the patients examined are still well without postoperative recurrence. Histologically, all cases demonstrated typical papillary architecture with fibrovascular cores. The mesothelial cells lining the papillae consisted mostly of single row of cells, although areas of proliferation to multiple layers were observed in a few cases. Their nuclei appeared bland, but two cases exhibited mild nuclear atypia and prominent nucleoli. Immunostaining revealed that the mesothelial cells were positive for D2-40, cytokeratin 5/6, cytokeratin 7, and Wilms' tumor 1.

  Conclusion: We herein demonstrated the clinicopathological characteristics of peritoneal WDPMs. WDPM has distinct pathological features. Although all cases we examined were uneventful after surgery, further surveillance is recommended since the biological behavior of WDPM is still uncertain.

  Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

• Early-stage Clinical Characterization of Malignant Pleural Mesothelioma. Y. Negi, K. Kuribayashi, N. Funaguchi, et al. 2018;32(5):1169-1174. PubMed · Publisher · Free full text

  Abstract

  Background/Aim: A strategy for improving survival of malignant pleural mesothelioma (MPM) patients is earlier diagnosis paired with earlier stage implementation of therapeutic interventions. This study aimed to determine the clinical signs of early-stage MPM to aid an earlier diagnosis and earlier-stage intervention.

  Materials And Methods: Out of the 72 cases in our institution, 40 cases with 18F-FDG-PET/CT-negative MPM were retrospectively identified between 2007 and 2015. Overall survival rates were determined and compared with pathological features, histology, and treatment.

  Results: The biphasic histological type of early-stage MPM was characterized by poor prognosis (p=0.0006). Additionally, the cytology-negative group (Class III and below) showed significantly shorter survival times (p=0.0290). There was no significant difference in survival between patients who received pleurectomy and those who received chemotherapy only (p=0.6991). Bimodal therapy resulted in a longer survival rate than trimodal therapy.

  Conclusion: In early-stage PET-negative MPM cases, biphasic histology and pleural effusion of Class III and below correlated with a poor prognosis. Surgical treatment using pleurectomy/decortication resulted in higher patient survival outcomes than therapy with extrapleural pneumonectomy.

  Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

• Carbon nanotubes induce granulomas but not mesotheliomas. C. Varga, K. Szendi. 2010;24(2):153-6. PubMed

  Abstract

  Background: Different types of carbon nanotubes may represent toxic hazards due to their size distribution and massive surface area. They may adsorb other toxic agents that can consequently be transported into the body. Hence the aim of this study was to confirm or reject the hypothesis of carcinogenicity of two types of carbon nanotubes.

  Materials And Methods: Well-defined single-walled and multi-walled carbon nanotubes were studied in a specific animal model for mesothelioma induction.

  Results: Short-term pilot studies were published on the asbestos fibre-like mesothelioma-inducing effects of carbon nanotubes based on the proposed mechanistic correlation on health effects of fibres of the same size. Our results with a simple in vivo, peritoneal exposure model refute such an interpretation. The present studies with rats indicate that early granuloma formation does not lead to the development of mesotheliomas during chronic exposure of peritoneal mesothelium to either single- or multi-walled carbon nanotubes of varied size.

  Conclusion: Due to the limited toxicity data on carbon nanotubes, these results may be particularly important for risk assessment purposes.

2000s

• An in vivo model for testing genotoxicity of environmental fibre-associated nitroarenes. C. Varga, K. Szendi, I. Ember. 2006;20(4):539-41. PubMed

  Abstract

  The environmental carcinogens nitroarenes are frequently adsorbed by asbestos fibres. An effective dose of 1-nitropyrene was studied in vivo. The mutagenic pattern of excreted urine of orally and intraperitoneally exposed rats was tested by the Ames mutagenicity assay. The characteristics of detected mutagenicity proved to be different in the two routes of exposure. TA 100 mutagenicity was only detected following i.p. exposure, while TA 98 revertant frequencies were increased significantly only after deconjugation, in both groups. Since environmental asbestos exposure involves carcinogenic effects of adsorbed polycyclic aromatic hydrocarbons, this animal model provides a useful tool for testing fibre-associated nitroarenes, in both mechanistic and risk assessment studies.

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