JACC. Case Reports

Our medical research library holds 5 studies published in JACC. Case Reports (2019–2026). Each entry links to the study's record on PubMed and, where there is one, to the publisher's page and a free full text. 5 have an abstract, the authors' own summary as PubMed records it: open "Abstract" to read it.

About the journal

• Publisher: Elsevier Inc
• Published: 2019 to the present, Netherlands
• Language: English
• ISSN: 2666-0849 (electronic)
• Its record in the NLM Catalog

2020s

• Radiation-Associated Mesothelioma With Mixed Constrictive-Restrictive Physiology After Mantle-Field Radiotherapy. R. Bensaber, J. Serratrice, N.K. Poku. 2026;31(39):109527. Case report PubMed · Publisher · Free full text

  Abstract

  Background: Malignant mesothelioma is a rare late complication of thoracic radiotherapy and may contribute to complex cardiothoracic manifestations decades after treatment.

  Case Summary: A 60-year-old woman treated for Hodgkin lymphoma with mantle radiotherapy and chemotherapy more than 40 years earlier presented with recurrent pleuropericarditis, heart failure symptoms, and recurrent pleural and pericardial effusions. Echocardiography and cardiac catheterization suggested constrictive physiology, whereas cardiac magnetic resonance was nondiagnostic. Positron emission tomography-computed tomography showed hypermetabolic pleural, mediastinal, and pericardial lesions. Despite anti-inflammatory therapy and corticosteroids, progressive congestion required near-total pericardiectomy. Histopathology revealed high-grade mesothelioma involving the mediastinum, pericardium, pleura, lungs, and myocardium. Following pericardiectomy, the restrictive component of a mixed constrictive-restrictive physiology became apparent, leading to cardiogenic shock requiring venoarterial extracorporeal membrane oxygenation.

  Discussion: Radiation-associated malignant mesothelioma is a rare but challenging late complication of thoracic radiotherapy and may contribute to mixed constrictive-restrictive physiology.

  Take-Home Message: Survivors of mantle-field radiotherapy for Hodgkin lymphoma remain at risk for both radiation-associated heart disease and secondary malignancies decades after treatment.

  Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.

• A Rare Cause of Constrictive Pericarditis: Primary Pericardial Mesothelioma. K. Ravindra, C. Vanchiere, V.A. Ferrari. 2025;30(16):103802. PubMed · Publisher · Free full text

  Abstract

  This clinical vignette highlights the use of echocardiography, computed tomography, positron emission tomography, magnetic resonance imaging, and invasive hemodynamics to aid in making a rare diagnosis. This case highlights a 62-year-old male who presented with worsening dyspnea and was ultimately found to have constrictive pericarditis secondary to primary pericardial mesothelioma. The use of multimodality imaging can facilitate early diagnosis of this rare condition, helping to initiate treatment options for an otherwise high-mortality disease.

  Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved.

• Molecular Characterization of Pericardial Mesothelioma With Constrictive and Recurrent Pericarditis: TAZ Amplification and Hippo Pathway. R. Tudino, S. Smith, L. Cheng, et al. 2025;30(38):105759. Case report PubMed · Publisher · Free full text

  Abstract

  Background: Malignant pericardial mesothelioma (MPM) is a rare, aggressive neoplasm with nonspecific clinical presentations. Although BAP1 loss and CDKN2A deletion are common in pleural mesothelioma, they are not universally present in MPM, complicating diagnosis.

  Case Summary: A 73-year-old man presented with recurrent fever and chest pain from pericarditis. Positron emission tomography-computed tomography and transthoracic echocardiography revealed pericardial thickening and aortitis, concerning for inflammatory or infectious etiology. Initial histopathology was inconclusive. Diagnosis of MPM was confirmed via lymph node biopsy and molecular profiling, which revealed TAZ amplification. The patient was treated with IL-1 blockage and chemotherapy, with symptom improvement.

  Discussion: In BAP1/CDKN2A-negative mesothelial proliferations, molecular testing for additional mutations, including TAZ amplification, may guide diagnostic certainty and novel therapeutic treatment.

  Take-Home Messages: MPM can closely mimic chronic inflammatory disease, and accurate diagnosis with comprehensive profiling is essential to guide targeted therapy. TAZ amplification suggests Hippo pathway as a driver of BAP-intact tumors and may serve as a predictive biomarker of mesothelial immunogenicity.

  Published by Elsevier Inc.

• Primary Pericardial Mesothelioma Causing Constrictive Pericarditis. S.T. Luebbe, Q. Youmans, T. Provias, et al. 2025;30(8):103204. PubMed · Publisher · Free full text

  Abstract

  We present a rare case of primary pericardial mesothelioma (PPM) causing constrictive pericarditis (CP). Our case highlights the importance of identifying the etiology of constriction and the role of multimodality imaging in CP. PPM is a primary pericardial malignancy and an unusual cause of CP that carries a grave prognosis despite pericardiectomy and/or chemotherapy. PPM can be difficult to diagnose and should be considered as a possibility when there is no other clear etiology of CP.

  Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved.

2010s

• Primary Malignant Pericardial Mesothelioma: A Clinical Case Series Illustrating the Necessity of a Multidisciplinary Approach. A.N. Rosenbaum, M.C. Bois, X. Zhang, et al. 2019;1(2):202-207. Case report PubMed · Publisher · Free full text

  Abstract

  Primary malignant pericardial mesothelioma is a rare cardiac neoplasm. The authors evaluated risk factors, clinical presentation, and outcomes by reviewing all biopsy-confirmed cases at one institution. The use of multimodality imaging, detailed hemodynamic assessment for the presence of an effusive-constrictive profile, and cytology evaluation can support the diagnosis. (Level of Difficulty: Advanced.).

  © 2019 The Authors.

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