Jornal Brasileiro de Pneumologia

Our medical research library holds 12 studies published in Jornal Brasileiro de Pneumologia (2014–2024). Each entry links to the study's record on PubMed and, where there is one, to the publisher's page and a free full text. 7 have an abstract, the authors' own summary as PubMed records it: open "Abstract" to read it. For 1 study PubMed has no abstract for, we give the abstract printed in the article or, where there is none, a summary we wrote from it, each labeled as such.

About the journal

• Publisher: Sociedade Brasileira de Pneumologia e Tisilogia
• Published: 2004–2025, Brazil
• Language: Portuguese
• ISSN: 1806-3713 (print), 1806-3756 (electronic)
• Continues: Jornal de Pneumologia
• Continued by: Respiratory Research & Clinical Practice
• Its record in the NLM Catalog

2020s

• Brazilian Thoracic Society recommendations for the diagnosis and monitoring of asbestos-exposed individuals. U.P. Santos, E. Algranti, E.M. Capitani, et al. 2024;50(3):e20240156. Guideline PubMed · Publisher · Free full text

  Abstract

  Asbestos was largely used in Brazil. It is a mineral that induces pleural and pulmonary fibrosis, and it is a potent carcinogen. Our objective was to develop recommendations for the performance of adequate imaging tests for screening asbestos-related diseases. We searched peer-reviewed publications, national and international technical documents, and specialists' opinions on the theme. Based on that, the major recommendations are: Individuals exposed to asbestos at the workplace for ≥ 1 year or those with a history of environmental exposure for at least 5 years, all of those with a latency period > 20 years from the date of initial exposure, should initially undego HRCT of the chest for investigation. Individuals with pleural disease and/or asbestosis should be considered for regular lung cancer monitoring. Risk calculators should be adopted for lung cancer screening, with a risk estimate of 1.5%.

• Identifying malignant mesothelioma by a pathological survey using the São Paulo state hospital cancer registry, Brazil. F.D.C. Bernardi, E. Algranti, M. Dolhnikoff, et al. 2024;50(2):e20230343. PubMed · Publisher · Free full text

  Abstract

  Objective: To review the pathological diagnosis of possible cases and/or hidden cases of malignant mesothelioma (MM) between 2000 and 2012 using the Hospital-Based Cancer Registry database in the state of São Paulo, Brazil.

  Methods: Possible cases were retrieved by assessing the database. Inclusion criteria were being older than 30 years of age and having ICD-O-3 topography and morphology codes related to MM. A board of expert pathologists reviewed the pathology reports and requested paraffin blocks in cases that demanded revision. After staining with calretinin, D2-40, WT-1 (as positive MM markers) and Ber-EP4 and MOC31 (as negative MM markers), cases were divided and studied independently by a pair of pathologists to confirm or discard the diagnosis of MM.

  Results: Our sample comprised 482 cases from 25 hospitals, and 130 needed further histological revision. We received 73 paraffin blocks with adequate material. After board analysis, there were 9 cases with a definitive diagnosis of MM, improving the diagnostic rate in 12%. Two cases of previously diagnosed MM were discarded by review.

  Conclusions: Our results confirm that part of MM underdiagnosis and underreporting in Brazil is due to incomplete or mistaken pathological diagnosis.

• Mesothelioma diagnosis-still a challenge. U.P. Santos. 2024;50(2):e20240118. Editorial PubMed · Publisher · Free full text

• Malignant mesothelioma: health care awareness and preparedness. E.M. Capitani, E. Algranti. 2022;48(5):e20220349. In English, Portuguese. Editorial · Comment PubMed · Publisher · Free full text

• Mesothelioma in a developing country: a retrospective analysis of the diagnostic process. P.H.P. Gregório, R.M. Terra, L.P. Lima, et al. 2022;48(5):e20220064. In English, Portuguese. PubMed · Publisher · Free full text

  Abstract

  Objective: To evaluate the process of diagnosing patients with malignant pleural mesothelioma (MPM) at a tertiary care hospital.

  Methods: This was a retrospective study involving patients referred to a tertiary-care cancer center in Brazil between 2009 and 2020. The diagnostic process was divided into four steps: onset of symptoms, referral to a specialist visit, histopathological diagnosis, and beginning of treatment. The intervals between each phase and the factors for delays were evaluated. Data including clinical status, radiological examinations, staging, treatment modalities, and survival outcomes were collected.

  Results: During the study period, 66 patients (mean age = 64 years) were diagnosed with MPM and underwent treatment. Only 27 (41%) of the patients had knowledge of prior exposure to asbestos. The median number of months (IQR) between the onset of symptoms and the first specialist visit, between the specialist visit and histopathological characterization, and between definite diagnosis and beginning of treatment was, respectively, 6.5 (2.0-11.4), 1.5 (0.6-2.1), and 1.7 (1.2-3.4). The knowledge of prior asbestos exposure was associated with a shorter time to referral to a specialist (median: 214 vs. 120 days; p = 0.04). A substantial number of nondiagnostic procedures and false-negative biopsy results (the majority of which involved the use of Cope needle biopsy) were found to be decisive factors for the length of waiting time. The mean overall survival was 11.9 months.

  Conclusions: The unfamiliarity of health professionals with MPM and the patient's lack of knowledge of prior asbestos exposure were the major factors to cause a long time interval between the onset of symptoms and beginning of treatment. An overall survival shorter than 1 year is likely to have been due to the aforementioned delays.

• Malignant pleural mesothelioma: an update. G.N.M. Hajj, C.H. Cavarson, C.A.L. Pinto, et al. 2021;47(6):e20210129. In English, Portuguese. Review PubMed · Publisher · Free full text

  Abstract

  Malignant mesotheliomas are rare types of cancers that affect the mesothelial surfaces, usually the pleura and peritoneum. They are associated with asbestos exposure, but due to a latency period of more than 30 years and difficult diagnosis, most cases are not detected until they reach advanced stages. Treatment options for this tumor type are very limited and survival ranges from 12 to 36 months. This review discusses the molecular physiopathology, current diagnosis, and latest therapeutic options for this disease.

• Validation of the Brazilian Portuguese version of the University of California San Diego Shortness of Breath Questionnaire in patients with interstitial lung disease. H. Silva, L.C. Mantoani, C.L. Zamboti, et al. 2021;47(6):e20210172. In English, Portuguese. PubMed · Publisher · Free full text

  Abstract

  Objective: To investigate the reliability, internal consistency and validity of the Brazilian Portuguese version of the University of California San Diego Shortness of Breath Questionnaire (UCSD SOBQ) in patients with interstitial lung disease (ILD).

  Methods: Patients with ILD completed the questionnaire at three different time points, one week apart, with the assistance of two independent assessors. Intra- and inter-rater reliability were analysed via the intraclass correlation coefficient (ICC). Internal consistency was assessed with the Cronbach's alpha coefficient. For the validity analysis, associations between variables were assessed with Spearman's or Pearson's correlation coefficient.

  Results: Thirty patients with ILD (idiopathic pulmonary fibrosis, connective tissue disease-associated pulmonary fibrosis, sarcoidosis, asbestosis or non-specific interstitial pneumonia) were included (15 men; mean age, 59 ± 10 years; DLCO: 46 [33-64] % predicted). UCSD SOBQ scores showed excellent agreement and internal consistency in the intra-rater analysis (ICC: 0.93 [0.85-0.97]; Cronbach alpha: 0.95) and in the inter-rater analysis (ICC: 0.95 [0.89-0.97]; Cronbach alpha: 0.95), as well as correlating significantly with dyspnoea (as assessed by the Medical Research Council scale; r = 0.56); Medical Outcomes Study 36-item Short-Form Health Survey domains bodily pain, general health, vitality and physical functioning (-0.40 ≤ r ≤ -0.74); six-minute walk distance (r = -0.38); and quadriceps muscle strength (r = -0.41).

  Conclusions: The Brazilian Portuguese version of the UCSD SOBQ is valid, is reliable and has internal consistency in patients with ILD in Brazil.

2010s

• Pleural calcifications. E. Marchiori, B. Hochhegger, G. Zanetti. 2018;44(6):447. In English, Portuguese. Case report PubMed · Publisher · Free full text

  Summary

  This one-page imaging case, published in a continuing education section by authors from two Brazilian universities, described pleural calcifications found on chest CT in an 87-year-old man. The patient had been diagnosed with prostate cancer, had no respiratory complaints, and underwent chest CT as part of an outpatient assessment. The scan showed multiple pleural plaques, several of them partially calcified, including calcified plaques on the diaphragmatic pleura. The authors listed the usual causes of pleural calcification: fibrothorax secondary to hemothorax, thoracic empyema or tuberculous pleural effusion, and exposure to asbestos fibers. They noted that pleural calcification is not always benign. Metastases of osteosarcoma can appear as calcification, and talc used for pleurodesis can mimic calcification because of its high density. They stated that pleural plaques are highly suggestive of asbestos-related pleural disease, particularly when the diaphragmatic pleura is involved. They described plaques as usually asymptomatic but as a marker of asbestos exposure that indicates greater risk of pulmonary fibrosis or asbestos-related malignancies. They also summarized the main HRCT findings of asbestosis. They noted that although asbestos had recently been banned in Brazil, its complications will still be seen for decades because of the long interval between exposure and disease. People at risk include both those directly exposed and those living near mines. Questioning of the patient revealed that he had lived near an asbestos mine for many decades and had worked in it for a few years. The authors concluded that this history, together with the imaging findings, was conclusive for a diagnosis of asbestos-related pleural plaques.

  PubMed has no abstract for this study, and the article doesn't print one. We wrote this summary from the full article with the help of AI. It is not the authors' wording.

• Usual interstitial pneumonia: typical, possible, and "inconsistent" patterns. P.P.T.E.S. Torres, M.F. Rabahi, M.A.C. Moreira, et al. 2017;43(5):393-398. In English, Portuguese. PubMed · Publisher · Free full text

  Abstract

  Idiopathic pulmonary fibrosis is a severe and progressive chronic fibrosing interstitial lung disease, a definitive diagnosis being established by specific combinations of clinical, radiological, and pathological findings. According to current international guidelines, HRCT plays a key role in establishing a diagnosis of usual interstitial pneumonia (UIP). Current guidelines describe three UIP patterns based on HRCT findings: a typical UIP pattern; a pattern designated "possible UIP"; and a pattern designated "inconsistent with UIP", each pattern having important diagnostic implications. A typical UIP pattern on HRCT is highly accurate for the presence of histopathological UIP, being currently considered to be diagnostic of UIP. The remaining patterns require further diagnostic investigation. Other known causes of a UIP pattern include drug-induced interstitial lung disease, chronic hypersensitivity pneumonitis, occupational diseases (e.g., asbestosis), and connective tissue diseases, all of which should be included in the clinical differential diagnosis. Given the importance of CT studies in establishing a diagnosis and the possibility of interobserver variability, the objective of this pictorial essay was to illustrate all three UIP patterns on HRCT.

• Comments on the introduction of the paper "Overview of the biochemical and genetic processes in malignant mesothelioma". A. Eduardo. 2014;40(5):584-5. In English, Portuguese. Letter · Comment PubMed · Publisher · Free full text

• Overview of the biochemical and genetic processes in malignant mesothelioma. L.V. Assis, M.C. Isoldi. 2014;40(4):429-42. In English, Portuguese. Review PubMed · Publisher · Free full text

  Abstract

  Malignant mesothelioma (MM) is a highly aggressive form of cancer, has a long latency period, and is resistant to chemotherapy. It is extremely fatal, with a mean survival of less than one year. The development of MM is strongly correlated with exposure to asbestos and with other factors, such as erionite and simian virus 40 [corrected]. Although various countries have banned the use of asbestos, MM has proven to be difficult to control and there appears to be a trend toward an increase in its incidence in the years to come. In Brazil, MM has not been widely studied from a genetic or biochemical standpoint. In addition, there have been few epidemiological studies of the disease, and the profile of its incidence has yet to be well established in the Brazilian population. The objective of this study was to review the literature regarding the processes of malignant transformation, as well as the respective mechanisms of tumorigenesis, in MM.

• The development of MM is strongly correlated with exposure to asbestos and erionite, as well as to simian virus 40”. L.D. Assis, M.C. Isoldi. 2014;40(5):586-7. In English, Portuguese. Comment PubMed · Publisher · Free full text

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