The British Journal of Surgery

Our medical research library holds 9 studies published in The British Journal of Surgery (1965–2013). Each entry links to the study's record on PubMed and, where there is one, to the publisher's page and a free full text. 5 have an abstract, the authors' own summary as PubMed records it: open "Abstract" to read it. For 3 studies PubMed has no abstract for, we give the abstract printed in the article or, where there is none, a summary we wrote from it, each labeled as such.

About the journal

• Publisher: Oxford University Press on behalf of BJS Foundation Ltd
• Published: 1913 to the present, England
• Language: English
• ISSN: 0007-1323 (print), 1365-2168 (electronic)
• Absorbed: European Journal of Surgery
• Absorbed: European Journal of Surgery. Supplement
• Absorbed: Swiss Surgery
• Absorbed: Swiss Surgery. Supplement
• Its record in the NLM Catalog

2010s

• Value of laparoscopy before cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis. L.H. Iversen, P.C. Rasmussen, S. Laurberg. 2013;100(2):285-92. PubMed · Publisher

  Abstract

  Background: The outcome of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) depends on the extent of peritoneal carcinomatosis. The role of laparoscopy in the preoperative assessment of extent of peritoneal carcinomatosis in potential candidates for cytoreductive surgery and HIPEC was evaluated in a consecutive series.

  Methods: Patients with peritoneal carcinomatosis from colorectal cancer or appendiceal cancer, pseudomyxoma peritonei or peritoneal mesothelioma referred to a single, national HIPEC centre were included prospectively between June 2006 and January 2012. From September 2010, preoperative evaluation also included a laparoscopy in patients deemed amenable to cytoreductive surgery and HIPEC after radiological evaluation, apart from those with pseudomyxoma peritonei with massive amounts of mucin.

  Results: In the period before laparoscopic evaluation, 70 patients underwent laparotomy of whom 39 (56 per cent) completed cytoreductive surgery and HIPEC. After the introduction of laparoscopic assessment, diagnostic laparoscopy was planned in 45 patients and successful in 43. The laparoscopic evaluation excluded 18 patients from surgery because of extensive disease, among other reasons. Laparoscopy was uneventful and associated with no deaths. Twenty-seven patients were considered amenable to cytoreductive surgery and HIPEC based on laparoscopic findings, of whom 17 completed this treatment; the disease was unresectable in the remaining ten patients. Of 13 patients who were not eligible for laparoscopic evaluation and were subjected to cytoreductive surgery plus HIPEC, 11 completed the procedure. The overall completion rate of cytoreductive surgery and HIPEC increased to 70 per cent (28 of 40) after the introduction of laparoscopic evaluation.

  Conclusion: Diagnostic laparoscopy was valuable in preoperative evaluation of the extent of peritoneal carcinomatosis, and improved patient selection for cytoreductive surgery and HIPEC.

  Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

• Multi-institutional experience of diffuse intra-abdominal multicystic peritoneal mesothelioma. T.C. Chua, T.D. Yan, M. Deraco, et al. 2011;98(1):60-4. PubMed · Publisher

  Abstract

  Background: This study was undertaken to measure survival of patients with multicystic peritoneal mesothelioma treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy through a multi-institutional collaboration.

  Methods: A multi-institutional data registry, established by the Peritoneal Surface Oncology Group, was used to identify patients with peritoneal mesothelioma and the subgroup with multicystic tumours, treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Outcomes for this subgroup are reported. The primary endpoint was overall survival. A secondary endpoint was the incidence of treatment-related complications.

  Results: Of 405 patients with peritoneal mesothelioma, 26 (6·4 per cent) had multicystic tumours. There were 20 women and six men with a mean(s.d.) age of 42(12) years. The median peritoneal carcinomatosis index (PCI) was 14 (range 6-39). There was no perioperative mortality. Six patients developed grade III or IV complications. After a median follow-up of 54 (range 5-129) months, all 26 patients were still alive.

  Conclusion: Multicystic peritoneal mesothelioma appears to be a distinct subtype of peritoneal mesothelioma, where long-term survival may be achieved through cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.

  Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

2000s

• Hyperthermic intraperitoneal chemoperfusion in the treatment of locally advanced intra-abdominal cancer. W.P. Ceelen, U. Hesse, B. de Hemptinne, et al. 2000;87(8):1006-15. Review PubMed · Publisher

  Abstract

  Background: Surgical treatment of intra-abdominal cancer is often followed by local recurrence. In a subgroup of patients, local recurrence is the sole site of disease, reflecting biologically low-grade malignancy. These patients might, therefore, benefit from local treatment. Recently, debulking surgery followed by hyperthermic chemoperfusion has been proposed in the treatment of locally advanced or recurrent intra-abdominal cancer. This paper reviews the rationale and assesses the currently accepted indications for and results of this novel treatment.

  Methods: A systematic web-based literature review was performed. Information was also retrieved from handbooks, congress abstracts and ongoing clinical trials.

  Results: A growing body of experimental evidence supports the use of hyperthermia combined with chemotherapy as an adjunct to cytoreductive surgery. Randomized clinical trials are available to support its use in the treatment and prevention of peritoneal carcinomatosis following resection of pathological tumour stage pT3 or pT4 gastric cancer; several other phase III trials are ongoing. Numerous phase I and II trials have reported good results for various other indications, with acceptable morbidity and mortality rates. Case mix, limited patient numbers and absence of a standardized technique are, however, a drawback in many of these series.

  Conclusion: For a subgroup of patients with peritoneal cancer without distant disease, debulking surgery followed by hyperthermic chemoperfusion may offer a chance of cure or palliation in this otherwise untreatable condition. This novel therapy should, however, be considered experimental until further results from ongoing phase III trials become available.

• Results of treatment of 33 patients with peritoneal mesothelioma. G. Sebbag, H. Yan, B.M. Shmookler, et al. 2000;87(11):1587-93. PubMed · Publisher

  Abstract

  Background: Peritoneal mesothelioma is a rare peritoneal malignancy, representing approximately one-third of all mesotheliomas. It is regarded as a universally fatal cancer with few treatment options.

  Methods: Records of 33 patients with peritoneal mesothelioma were reviewed retrospectively. Demographic, clinical and quantitative prognostic indicators were evaluated and analysed statistically using survival as endpoint. Patients were treated by a uniform strategy involving cytoreductive surgery with peritonectomy procedures and perioperative intraperitoneal chemotherapy (cisplatin, doxorubicin).

  Results: There were ten women and 23 men; mean age was 53.0 years. Asbestos exposure was recorded in five patients and a family history of cancer in 13. Presentation was mainly abdominal distension and pain. Median survival was 31.0 months; overall projected survival at 3 years was 56 per cent. The most significant positive predictive factors of survival were: female sex (P= 0.003), low prior surgical score (P=0.002), completeness of cytoreduction (P=0.0002) and second-look surgery (P=0.019). The morbidity rate for this combined treatment was 33 per cent and the perioperative mortality rate was 3 per cent.

  Conclusion: Although peritoneal mesothelioma is rare, progress in its management has occurred. Survival has been extended and selection factors by which patients may be allocated to aggressive management strategies have been defined.

1970s

• Peritoneal nesothelioma. P.S. Chan, T.W. Balfour, J.B. Bourke, et al. 1975;62(7):576-80. Case report PubMed · Publisher

  Abstract

  Two patients with primary peritoneal mesothelioma are reported. They had abdominal symptoms, no symptoms referable to the respiratory system and normal chest X-rays. There was no clinical evidence of impaired respiratory function. One of the patients had a history of brief asbestos exposure over 20 years before diagnosis. The procedure for obtaining compensation is outlined and the protean uses of, and hence possible exposure to, asbestos are noted. In screening programmes consideration should be given to both pulmonary and abdominal symptoms. Laparoscopy may have a part to play in earlier diagnosis of peritoneal mesothelioma.

• Surgical biopsy studies of omental and peritoneal nodules. D.B. Walsh, G. Williams. 1971;58(6):428-33. PubMed · Publisher

  Abstract

  Four hundred and thirty-five biopsy specimens from the peritoneum and omentum submitted for diagnosis in a major teaching hospital over a 17-year period are reviewed. Their histopathology and incidence are recorded in the light of relevant clinical data. Some of the problems in the diagnosis of the lesions and various factors influencing their statistical breakdown are discussed.

  PubMed has no abstract for this study. This is the authors' abstract, copied from the article.

• Peritoneal mesothelioma. A report of 4 cases. G.H. Roberts, R.W. Irvine. 1970;57(9):645-50. PubMed · Publisher

  Abstract

  Four cases of peritoneal mesothelioma occurring in 1 hospital in the course of 1 year are reported. The clinical picture is relatively non-specific and dominated by progressive abdominal distension and pain; all 4 patients died within 13 months. The value of cytology, laparotomy, and peritoneal biopsy as aids to diagnosis is discussed. Evidence of exposure to asbestos was found in 3 of the 4 cases. No treatment appears to alter the fairly rapid progression of the disease, and palliation of symptoms is all that can be offered.

  PubMed has no abstract for this study. This is the authors' abstract, copied from the article.

1960s

• Peritoneal mesothelioma presenting surgically. P.G. Smith, P.M. Higgins, W.D. Park. 1968;55(9):681-4. PubMed · Publisher

  Abstract

  Two cases of peritoneal mesothelioma are recorded and the clinical presentations of 10 additional cases analysed. Differentiation of peritoneal mesothelioma from carcinomatosis peritonei is discussed. The close association with asbestos is illustrated and the risk discussed. A history of asbestos exposure should always raise the possibility of mesothelioma in cases of disseminated peritoneal growth.

  PubMed has no abstract for this study. This is the authors' abstract, copied from the article.

• The mesotheliomas of the small intestine. M. Paul, G. Panabokke, M.H. Dezoysa. 1965;52:46-8. PubMed · Publisher

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