Clinical Case Reports

Our medical research library holds 15 studies published in Clinical Case Reports (2015–2025). Each entry links to the study's record on PubMed and, where there is one, to the publisher's page and a free full text. 15 have an abstract, the authors' own summary as PubMed records it: open "Abstract" to read it.

About the journal

• Publisher: John Wiley & Sons
• Published: 2013 to the present, England
• Language: English
• ISSN: 2050-0904 (electronic)
• Its record in the NLM Catalog

2020s

• Incidental Finding of Giant Pericardial Lipoma in a Patient Referred for Rectal Bleeding. Differential Diagnosis and Treatment. S. Campana, F. Ferrentino, M. Torri, et al. 2025;13(7):e70502. PubMed · Publisher · Free full text

  Abstract

  Large circumferential tumors encasing the heart are exceedingly rare, and the differential diagnosis include primary pericardial sarcomas, non-Hodgkin lymphoma, pericardial primitive neuroectodermal tumor, primary pericardial mesothelioma, and exceptionally mature benign lipoma. Lipomas are rare primary heart tumors. Most are epicardial in origin, although they may arise in the myocardium. They are usually soft masses of mature fat tissue encapsulated by a thin layer of fibrous tissue. Signs and symptoms depend on the tumor's location and size, however in several case they are found incidentally at cardiac imaging. In this 48-year-old woman referred to the emergency department for severe intestinal bleeding, echocardiography showed a large circumferential hypoechogenic space, and CT confirmed a large mediastinal fat mass encasing the heart. Multimodal imaging allowed differential diagnosis confirmed by histologic examination performed at surgery.

  © 2025 The Author(s). Clinical Case Reports published by John Wiley & Sons Ltd.

• A rare presentation of malignant mesothelioma of the tunica vaginalis managed with immunotherapy and review of the literature. K. Mishra, S. Siddiquee, A.R. Mislang. 2023;11(6):e7610. Case report PubMed · Publisher · Free full text

  Abstract

  Key Clinical Message: We describe the first case in literature of malignant mesothelioma of the tunica vaginalis that has shown partial response to systemic immunotherapy (ipilimumab-nivolumab) post orchiectomy, warranting further investigation in a trial setting.

  Abstract: We present a case report of an 80-year-old ex-smoker with a rare diagnosis of metastatic mesothelioma of the tunica vaginalis, managed with immunotherapy. The patient, with no known history of asbestos exposure, presented with a left scrotal mass and pain. Scrotal ultrasound confirmed a large paratesticular mass, and computed tomography (CT) of the chest, abdomen, and pelvis revealed a bilobed mass in the left scrotal compartment without associated inguinal or abdominopelvic lymphadenopathy, and an indeterminate, subcentimeter, bi-basal subpleural nodules. He underwent a left orchiectomy, and histopathology confirmed the diagnosis of a paratesticular mesothelioma. Postoperatively, the patient had a positron emission tomography (PET) scan showing a new right pleural effusion as well as increasing size of the lobar and pleural nodules bilaterally, all metabolically active and suggestive of progressive metastatic disease. The patient was commenced on ipilimumab and nivolumab immunotherapy, a regimen indicated for malignant pleural mesothelioma; however, the efficacy on paratesticular mesothelioma is not known. After 6 months of treatment, the patient demonstrated a partial response to immunotherapy, with a reduction in the size of known pleural nodules and effusion.Literature review suggests that diagnosis requires a high index of suspicion and patients commonly have metastatic disease at the time of diagnosis. Orchiectomy is a common management modality. However, the role, regimen, and benefits of systemic therapy are unclear, warranting further studies investigating management strategies.

  © 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

• Malignant pleural mesothelioma with constrictive pericarditis as the first manifestation: A case report. C.P. He, D.W. Tu, T.W. Zhang, et al. 2023;11(6):e7555. Case report PubMed · Publisher · Free full text

  Abstract

  Pleural mesothelioma (PM) with pericardial involvement is extremely rare. We now report a rare case of malignant PM with constrictive pericarditis as the first presentation. A 59-year-old male diagnosed with constrictive pericarditis underwent pericardiectomy and pericardial pathology revealed mesothelial hyperplasia. Eight months after surgery, the patient was admitted to the hospital with chest tightness and wheezing for 5 days. Computed tomography scan of the chest showed a left lung expansion insufficiency, limited bilateral pleural thickening, pericardial thickening with a small amount of pericardial effusion, and multiple enlarged lymph nodes in the mediastinum, bilateral supraclavicular fossa, bilateral cervical roots, and right axilla. The pleural malignancy should be possibly considered. Pathology after pleural puncture showed malignant PM. Pathology after left supraclavicular lymph node puncture biopsy showed metastatic malignant mesothelioma. The diagnosis of this patient was clear. Although malignant PM rarely involves the pericardial constriction, we cannot ignore the fact that malignant PM involves the pericardium. The patient has been diagnosed with constrictive pericarditis, accompanied by pleural thickening and pleural effusion. Without other pathogenic factors, pleural biopsy should be aggressively performed in patients with constrictive pericarditis to determine the cause.

  © 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

• Recurrent malignant peritoneal mesothelioma treated by a second resection: A case report. T. Miyata, H. Nishiki, Y. Shinden, et al. 2023;11(5):e7383. Case report PubMed · Publisher · Free full text

  Abstract

  Key Clinical Message: Malignant peritoneal mesothelioma, a rare and poor prognosis disease, is seldom treated surgically, especially for recurrence. However, early diagnosis and aggressive treatment of primary and recurrent tumors can achieve long-term patient survival.

  Abstract: Malignant peritoneal mesothelioma (MPM) is a rare and aggressive tumor, and rarely indicated for surgery, especially for recurrence. In the present case, we report a rare case who could survive long-term after two surgeries in 4 years for MPM.

  © 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

• Thrombocytosis as a paraneoplastic syndrome in metastatic malignant peritoneal mesothelioma of biphasic morphology mimicking ovarian adenocarcinoma: A case report. M.S. Alhamadh, R.B. Alanazi, O.M. Wadaan, et al. 2023;11(3):e6974. Case report PubMed · Publisher · Free full text

  Abstract

  Malignant peritoneal mesothelioma (MPM) is a rare malignancy, presenting with non-specific and potentially-misleading manifestations. It represents a diagnostic pitfall as it mimics ovarian carcinoma. Maintaining a low diagnostic threshold, obtaining a detailed history, and utilizing immunohistochemical markers to diagnose MPM is crucial as early diagnosis and treatment might improve survival.

  © 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

• Benign peritoneal cystic mesothelioma mimicking peritoneal tuberculosis. C. Soltani, K.B. Abdallah, Y. Bouchallouf. 2022;10(12):e6672. Case report PubMed · Publisher · Free full text

  Abstract

  In immunodeficient patients with repetitive peritoneal aggression, cystic mesothelioma should be considered as a differential diagnosis to peritoneal tuberculosis that must be ruled out in endemic countries.

  © 2022 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

• A case of multiple primary malignancies including peritoneal mesothelioma surviving over 11 years. E. Esmati, S. Rezaei, F. Jafari. 2021;9(5):e04096. Case report PubMed · Publisher · Free full text

  Abstract

  Multiple primary malignancies are exceedingly rare, but they may occur sequentially in a patient, so in the follow-up of patients with a history of malignancy, always pay attention to second and third primary malignancies as well.

  © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

• A case of nonislet cell tumor hypoglycemia associated with malignant mesothelioma requiring a multifaceted approach for optimal glycemic control. M. Ono, Y. Maeda, N. Koyama, et al. 2021;9(10):e05028. Case report PubMed · Publisher · Free full text

  Abstract

  Nonislet tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome characterized by refractory hypoglycemia, which often requires multifaceted therapy. We reported a case of a patient with pleural malignant mesothelioma and developed NICTH, for which chemotherapy, glucocorticoids, and nutrition were given to achieve optimal glycemic control.

  © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

• Nivolumab-induced liver injury with a steroid-refractory increase in biliary enzymes, in a patient with malignant mesothelioma: An autopsy case report. K. Arai, M. Matsuda, H. Nakayasu, et al. 2021;9(12):e05174. Case report PubMed · Publisher · Free full text

  Abstract

  This is the first autopsy report of hepatotoxicity from nivolumab immunotherapy for malignant mesothelioma. The increase in levels of biliary enzymes and randomly distributed endothelial damage were steroid-refractory, but second-line option was abandoned because of cachexia. Further discussions are needed regarding the customized management of immune-related toxicities.

  © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

• Peritoneal mesothelioma associated with bladder cancer and occupational exposure to asbestos: A case report. D. Brahim, N. Mechergui, H. Ben Said, et al. 2020;8(12):3529-3532. Case report PubMed · Publisher · Free full text

  Abstract

  Mesothelioma is a rare tumor usually located on the pleura. In this typical location, it is closely linked to asbestos exposure. However, in other locations such as in peritoneal mesothelioma, the association to asbestos remains unusual.

  © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

2010s

• Malignant pleural mesothelioma: Is reconstruction of the diaphragm necessary in left pleurectomy/decortication? A case report. A. Testori, M. De Simone, E. Bottoni, et al. 2019;7(2):299-301. Case report PubMed · Publisher · Free full text

  Abstract

  We describe a case of complete intrathoracic stomach and intestinal herniation after pleurectomy/decortication due to diaphragm reconstruction without mesh. Is reconstruction with mesh always necessary? Can lung sparing obviate the tension on residual diaphragm? These are the questions not well described to which we try to give an answer.

• Management of recurrent pleural mesothelioma: Successful rechallenge with nintedanib in combination with chemotherapy. F. Grosso, A. Roveta, G. Gallizzi, et al. 2018;6(10):2000-2004. Case report PubMed · Publisher · Free full text

  Abstract

  Malignant pleural mesothelioma (MPM) is a rare neoplasm, generally caused by asbestos exposure. This case details how a patient treated with nintedanib during the LUME-Meso study was rechallenged with nintedanib. The findings highlight the benefit of nintedanib rechallenge and the potential use of continuous anti-angiogenic therapy in MPM treatment.

• A case of severe arthralgia with malignant mesothelioma-associated hypertrophic osteoarthropathy. H. Yamakawa, A. Sekine, T. Kato, et al. 2016;4(11):1057-1060. Case report PubMed · Publisher · Free full text

  Abstract

  Hypertrophic osteoarthropathy (HOA) is a rare syndrome characterized by the abnormal proliferation of dermato-osseous tissue. We report a rare case of malignant mesothelioma-associated HOA who suffered from refractory painful osteoarthropathy. HOA can be associated with malignant mesothelioma and that may be resistant to any treatment.

• Doctor, I am sweating on just one side of my body: unilateral hyperhidrosis associated with mesothelioma. E. Waran. 2016;4(5):533-4. PubMed · Publisher · Free full text

  Abstract

  Unilateral hyperhidrosis is rare and should prompt a thorough review for potentially serious underlying etiologies. Available treatments for unilateral hyperhidrosis secondary to mesothelioma are limited and its presence as a symptom usually signifies advanced disease and a poor prognosis.

• Rapidly progressive sarcomatoid malignant mesothelioma of the pleura mimicking pulmonary empyema. K. Fujita, Y.H. Kim, K. Nakatani, et al. 2015;3(10):875-8. Case report PubMed · Publisher · Free full text

  Abstract

  Refractory empyema occasionally reflects hidden malignant disease. We presented a rare case of rapidly progressive malignant mesothelioma of the pleura (MPM) mimicking empyema. Physicians should be aware of MPM when patients with empyema are refractory to the standard treatment, and PET-CT may be helpful in establishing a precise diagnosis in such cases.

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