Ecancermedicalscience

Our medical research library holds 5 studies published in Ecancermedicalscience (2015–2025). Each entry links to the study's record on PubMed and, where there is one, to the publisher's page and a free full text. 5 have an abstract, the authors' own summary as PubMed records it: open "Abstract" to read it.

About the journal

• Publisher: ecancer
• Published: 2007 to the present, England
• Language: English
• ISSN: 1754-6605 (electronic)
• Its record in the NLM Catalog

2020s

• Mortality rate for mesothelioma as a basic cause in the period 2017-2022 in Chile. F. Quintanilla, Á. Torres, M. Villar, et al. 2025;19:1927. PubMed · Publisher · Free full text

  Abstract

  Introduction: Mesothelioma is a neoplasm associated with asbestos exposure. Due to the lack of updated national epidemiological data, it was decided to determine the mortality rate (MT) due to mesothelioma during the period 2017-2022 in Chile.

  Materials And Methods: Observational, descriptive and cross-sectional study. A descriptive analysis of mortality rate (TM) due to mesothelioma as a basic cause during the period 2017-2022 in Chile in patients aged 45 years and older was performed, analysing the variables sex, age, national region, anatomical site affected and place of death. Data were obtained from the Department of Health Statistics and Information and the National Institute of Statistics and were analysed using Microsoft Office Excel. No evaluation by an ethics committee was required.

  Results: We studied 362 deaths, determining a TM for the period of 0.97 deaths per 100,000 inhabitants, where the highest rate was recorded in 2019. There was a predominance in men, with a male excess MT of 2.19, as well as in those over 80 years of age and residents in the region of Arica and Parinacota. In most cases, the tumour location was not determined, but among those identified, the most frequent was of pleural origin. Most deaths occurred at home.

  Discussion: The findings show that the highest MTs are concentrated in men, the elderly and mining regions, groups in which exposure to asbestos is quite probable, both for occupational and residential reasons.

  Conclusion: The need to maintain active surveillance and high suspicion for mesothelioma is emphasised, with the application of public health measures for early diagnosis and adequate management.

  © the authors; licensee ecancermedicalscience.

2010s

• Environmental exposures and cancer: using the precautionary principle. L. Cohen, A. Jefferies. 2019;13:ed91. Editorial PubMed · Publisher · Free full text

  Abstract

  Since the 1970s, more than 87,000 chemicals have been approved for commercial use. Yet of those thousands of chemicals, only just over one thousand have been formally examined and graded for their carcinogenic potential. Of those, five hundred have been found worthy of being graded on a cautiously worded scale ranging from "known" carcinogens to "possibly" carcinogenic. In addition to carcinogenic substances, a new field has emerged researching how environmental toxins cause endocrine or hormonal disruption. A class of these compounds known as endocrine-disrupting chemicals (EDCs) can be found in our food, our environment, and in the products we put on our bodies. Rather than being directly linked to causing cancer, like substances such as asbestos, EDCs influence our health by mimicking or enhancing or changing metabolic regulation. These compounds interfere with hormone production and metabolism in ways that may-especially over the long term-create biological conditions that make us more susceptible to cancer and other diseases. Most of us are exposed to a cocktail of environmental toxins on an ongoing daily basis and at a relatively low level of exposure. Given the lax regulation of chemicals and the reactionary approach of government regulators, it is up to the consumer to be diligent about reading labels and making healthy choices to limit exposure to chemicals and toxins. It is ideal to adopt the Precautionary Principle: until a chemical is found to be harmless, try to not use it. The precautionary principle means that you are maintaining awareness of what you are putting on and in your body and taking steps to avoid exposing yourself unnecessarily to toxins in your household and environment.

• Learning from the past to design better trials in second-line treatment for mesothelioma patients. A. Addeo, G.L. Banna, P.Y. Dietrich. 2018;12:881. PubMed · Publisher · Free full text

  Abstract

  Malignant pleural mesothelioma (MPM) is an aggressive cancer characterised by modest sensitivity to systemic chemotherapy. The standard treatment remains platinum-based chemotherapy with pemetrexed. Recently, the addition of an antiangiogenic drug, bevacizumab, to first-line chemotherapy has been shown to improve overall survival. All the patients, unfortunately, will progress, and currently, there is no standard treatment approved in second-line. Recently, the results of the NGR015 phase III randomised with NGR-hTNF plus chemotherapy versus placebo in addition to physician's choice second-line chemotherapy for MPM have been published. Despite encouraging data achieved in previous phase I and phase II studies, the NGR-hTNF drug failed to meet the primary endpoint of the study, although a signal of activity was observed in the group of patients who had a shorter treatment failure interval from the first-line treatment. Hereby, we start from this recent trial to highlight once more the importance of thoroughly investigating possible predictive factors during the early drug development phase to allow more efficient phase III trial design, thus avoiding the possibility of potentially effective molecules like NGR-hTNF, continuing to be wasted.

• The first case of benign multicystic mesothelioma presenting as a splenic mass. A. D'Antonio, C. Baldi, M. Addesso, et al. 2016;10:678. Case report PubMed · Publisher · Free full text

  Abstract

  Multicystic mesothelioma (MM) is a relatively rare tumour arising in the pelvic peritoneum of the tuboovarian region of young woman. Exceptionally, MM occurs on the serosal surfaces of various organs including kidney, bladder, lymph nodes, and liver. We report here the first case of MM wherein a 58-year-old woman with a previous history of endometriosis of the right ovary presented with a large multicystic mass of the spleen. The diagnosis of MM was made on a surgical specimen after splenectomy. A histopathologic examination is always necessary for the diagnosis of MM which should be differentiated from other lesions particularly from cystic lymphangioma. At one year follow-up, the patient had no evidence of recurrence. Despite the high frequency of local recurrences, MM is a benign lesion and 'en bloc' surgical excision with prolonged follow-ups is the treatment of choice.

• Asymptomatic peritoneal carcinomatosis originating from benign cystic peritoneal mesothelioma. S. Iacoponi, J. Calleja, G. Hernandez, et al. 2015;9:605. Case report PubMed · Publisher · Free full text

  Abstract

  Benign multicystic mesothelioma is a rare tumour that originates from the abdominal peritoneum with a predisposition to the pelvic peritoneum. It typically affects women of reproductive age. There have been less than 200 cases of this rare neoplasia reported to date. We present the case of a 35-year-old woman who was referred to our centre because of the detection of a peritoneal carcinomatosis during a gynaecological exam. A diagnostic laparoscopy was performed. The findings included multiple cysts appearing as 'a bunch of grapes' occupying the omentum. Biopsies were taken during the surgery and the results showed benign multicystic peritoneal mesothelioma. Benign multicystic mesothelioma can simulate other conditions, such as malignant ovarian tumours or cystic lymphangioma. It is often diagnosed accidentally during surgery performed for another reason. The diagnosis is interoperative, observing multicystic structures grouped as a 'bunch of grapes' containing clear fluid with thin walls made of connective tissue. Immunohistochemistry confirmed mesothelial origin. Surgery is considered the treatment of choice and is based on the removal of the cysts from the abdominal cavity. Hyperthermic intraperitoneal chemotherapy can be considered as a primary treatment in patients with recurrences or even as a part of primary treatment associated with surgery. Survival at 5 years is 100% and invasive or malignant progression is extraordinary. The treatment approach should be multidisciplinary, and the patient should be referred to a referral centre.

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