The Science of the Total Environment

Our medical research library holds 56 studies published in The Science of the Total Environment (1974–2025). Each entry links to the study's record on PubMed and, where there is one, to the publisher's page and a free full text. 52 have an abstract, the authors' own summary as PubMed records it: open "Abstract" to read it.

About the journal

• Publisher: Elsevier
• Published: 1972 to the present, Netherlands
• Language: English
• ISSN: 0048-9697 (print), 1879-1026 (electronic)
• Its record in the NLM Catalog

2020s

• Naturally occurring asbestos in Southern Italy: Geological and mineralogical investigation of fibrous antigorite from Calabrian serpentinites in view of its hazard assessment. J.R. Petriglieri, G. Capitani, P. Ballirano, et al. 2025;970:178970. PubMed · Publisher

  Abstract

  In the last few decades, non-occupational asbestos-related diseases have been documented in populations living near naturally occurring asbestos (NOA) sites, including regions in Greece, Cyprus, China, New Caledonia, Turkey, and Italy. This highlights the critical need to assess geological and environmental hazards associated with NOA. Fibrous antigorite, among the >400 naturally occurring fibrous minerals, has emerged as a potential health and environmental hazard. This work examines the morphometrical, mineralogical and surface properties of a fibrous antigorite vein from a serpentinite body at San Mango D'Aquino (Calabria, Italy), relevant to assessing its potential toxicity. The geological site, described through field and petrographic analyses, was selected as representative of serpentinites outcropping over a large area in central Calabria. Results on the morphometric variation induced by a standardized mechanical stress, mineral solubility, and surface chemical reactivity indicated that: i) the fibrous morphology, expressed as % of WHO (World Health Organization) fibres, was largely preserved and consistent with asbestos standards; ii) antigorite fibres have a durability higher than chrysotile and close to a previously characterized fibrous antigorite from Val Varenna, Italy; iii) fibres showed a remarkable redox reactivity, even higher than chrysotile, suggesting that they may promote particle-derived radical imbalance in vitro and in vivo. Our findings revealed that the antigorite fibres from San Mango possess several critical properties commonly associated with asbestos toxicity. On this basis, we identify the NOA site of San Mango as a potential emission source of hazardous antigorite fibres, with significant environmental and public health implications for the surrounding communities.

  Copyright © 2025 The Authors. Published by Elsevier B.V. All rights reserved.

• An urgent call to action: The absolute necessity to ban asbestos production and sales. Y. Takefuji. 2024;906:167557. PubMed · Publisher

  Abstract

  The issue with asbestos highlights the shortcomings in the global management of health policies for dangerous substances. The perils of asbestos dust were identified about a century ago. A significant number of individuals succumb to asbestos-related diseases worldwide annually. A considerable portion of occupational cancer fatalities are believed to be due to asbestos. A large population across the globe is exposed to asbestos in their workplaces. To address issues like asbestos, it is crucial for policymakers to prioritize public interest, and third parties should actively participate in scrutinizing the actions of these policymakers.

  Copyright © 2023 Elsevier B.V. All rights reserved.

• Assessing potentially toxic elements (PTEs) content in asbestos and related groundwater: A review of the levels detected. A. Bloise, I. Fuoco, G. Vespasiano, et al. 2024;955:177116. Review PubMed · Publisher

  Abstract

  This article provides a review of published literature on the concentration levels of potentially toxic elements (PTEs) in asbestos minerals like chrysotile, actinolite, amosite (asbestiform grunerite), anthophyllite, crocidolite (asbestiform riebeckite) and tremolite and their potential to release PTEs into groundwaters worldwide. A large number of PTEs, such as Fe, Cr, Ni, Mn, Co and Zn, may be hosted by asbestos minerals, and their release in the lung environment can cause different health problems as well as their intake via drinking water. The review highlights that amosite is the phase with the highest PTEs content, followed by crocidolite, actinolite, anthophyllite, tremolite and chrysotile. Chrysotile, tremolite, and anthophyllite contain higher levels of Cr, Ni, and Co, while Fe and Mn are more enriched in amosite and crocidolite. Actinolite contains a high concentration of all considered PTEs. High levels of Cr, Fe, Zn, Mn, and Ni were also detected in groundwater interacting with ophiolite rocks containing asbestos minerals. The three main recognized hydro-geochemical facies (Mg-HCO3, Ca-HCO3 and Ca-OH), characterizing the ophiolite aquifers, show high levels of Cr and Ni, with values sometimes above the World health Organization (WHO) thresholds for drinking waters, which can cause adverse health effects in short and long term. The knowledge emerging from this work is a significant contribution to the already wide frame of understanding asbestos-related diseases and provide a strong scientific basis for further mineralogical and geochemical studies.

  Copyright © 2024. Published by Elsevier B.V.

• Exploring microbial diversity and interactions for asbestos modifying properties. L.C. Wong, U. Rodenburg, R.R. Leite, et al. 2024;951:175577. PubMed · Publisher

  Abstract

  Asbestos poses a substantial environmental health risk, and biological treatment offers a promising approach to mitigate its impact by altering its chemical composition. However, the dynamics of microbial co-inoculation in asbestos bioremediation remain poorly understood. This study investigates the effect of microbial single cultures and co-cultures on modifying crocidolite and chrysotile fibers, focusing on the extraction of iron and magnesium. Seventy bacterial and eighty-three fungal strains were isolated from five diverse sites, characterized phylogenetically using the 16S rRNA gene and ITS region, respectively, and assessed for siderophore and organic acid production. Most bacterial strains were identified as Pseudomonas, while Penicillium predominated among fungal strains. Ten bacterial and 25 fungal strains were found to produce both organic compounds. Four microbial co-cultures (one bacterium-bacterium, two fungus-bacterium, and one fungus-fungus) exhibiting synergistic effects in plate assays, alongside their respective single cultures, were incubated with crocidolite and chrysotile. ICP-OES analysis revealed that in crocidolite, the co-culture HRF19-HRB12 removed more iron than their single cultures, while Penicillium TPF36 showed the highest iron removal. The co-culture of two Pseudomonas strains (HRB12-RB5) exhibited the highest magnesium concentration in the supernatant. In chrysotile, the co-culture HRB12-RB5 removed more iron than their individual cultures, with Penicillium TFSF27 exhibiting the highest iron concentration in the solution. Penicillium TFSF27 and the co-culture TFSF27-TPF36 demonstrated the highest magnesium removal. SEM-XRMA analysis showed a significant reduction in iron and magnesium content, confirming elemental extraction from the fibers' structure. This study significantly broadens the range of microbial strains capable of modifying asbestos fibers and underscores the potential of microbial co-cultures in asbestos remediation.

  Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.

• Assessing pollution and health risks from chromite mine tailings contaminated soils in India by employing synergistic statistical approaches. S. Banerjee, S. Ghosh, S. Jha, et al. 2023;880:163228. PubMed · Publisher

  Abstract

  Potentially toxic elements (PTEs) contamination in the agricultural soil can generate a detrimental effect on the ecosystem and poses a threat to human health. The present work evaluates the PTEs concentration, source identification, probabilistic assessment of health hazards, and dietary risk analysis due to PTEs pollution in the region of the chromite-asbestos mine, India. To evaluate the health risks associated with PTEs in soil, soil tailings and rice grains were collected and studied. The results revealed that the PTEs concentration (mainly Cr and Ni) of total, DTPA-bioavailable, and rice grain was significantly above the permissible limit in site 1 (tailings) and site 2 (contaminated) as compared with site 3 (uncontaminated). The Free ion activity model (FIAM) was applied to detect the solubility of PTEs in polluted soil and their probable transfer from soil to rice grain. The hazard quotient values were significantly higher than the safe (FIAM-HQ < 0.5) for Cr (1.50E+00), Ni (1.32E+00), and, Pb (5.55E+00) except for Cd (1.43E-03), Cu (5.82E-02). Severity adjustment margin of exposure (SAMOE) results denote that the PTEs contaminated raw rice grain has high health risk [CrSAMOE: 0.001; NiSAMOE: 0.002; CdSAMOE: 0.007; PbSAMOE: 0.008] for humans except for Cu. The Positive matrix factorization (PMF) along with correlation used to apportion the source. Self-organizing map (SOM) and PMF analysis identified the source of pollution mainly from mines in this region. Monte Carlo simulation (MCS) revealed that TCR (total carcinogenic risk) cannot be insignificant and children were the maximum sufferers relative to adults via ingestion-pathway. In the spatial distribution map, the region nearer to mine is highly prone to ecological risk with respect to PTEs pollution. Based on appropriate and reasonable evaluation methods, this work will help environmental scientists and policymakers' control PTEs pollution in agricultural soils near the vicinity of mines.

  Copyright © 2023 Elsevier B.V. All rights reserved.

• Assessment of trace element contamination and effects on Paracentrotus lividus using several approaches: Pollution indices, accumulation factors and biochemical tools. O. El Idrissi, S. Ternengo, B. Monnier, et al. 2023;869:161686. PubMed · Publisher

  Abstract

  Among the most common contaminants in marine ecosystems, trace elements are recognized as serious pollutants. In Corsica (NW Mediterranean Sea), near the old asbestos mine at Canari, trace elements from the leaching of mine residues have been discharged into the sea for several decades. The aim of this study was to assess the levels of contamination in this area and the potential effects on Paracentrotus lividus (Lamarck, 1816) using pollution indices, accumulation factors and biochemical tools. For this purpose, the concentration of 24 trace elements was measured in sea urchins (gonads and gut content), macroalgae, seawater column and sediment collected at 12 stations nearby the old asbestos mine and at a reference site. The bioaccumulation of trace elements occurs as follows: macroalgae > gut > gonads. TEPI contribute to highlight contamination gradients which are mainly due to the dominant marine currents allowing the migration of mining waste along the coastline. This hypothesis was supported by TESVI, which identified characteristic trace elements in the southern area of the mine. High hydrogen peroxide content, associated with elevated catalase and glutathione-S-transferase enzyme activities, were also identified at these sites and at the reference site. Trace elements contamination as well as several abiotic factors could explain these results (e.g. microbiological contamination, hydrodynamic events, etc.). The results obtained in this study suggest that oxidative stress induced by contamination does not affect the health of Paracentrotus lividus. This work has provided a useful dataset allowing better use of sea urchins and various tools for assessing trace element contamination in coastal ecosystems.

  Copyright © 2023 Elsevier B.V. All rights reserved.

• Global, regional, and national burden of asbestosis from 1990 to 2019 and the implications for prevention and control. Z. Ou, X. Li, J. Cui, et al. 2023;904:166346. PubMed · Publisher

  Abstract

  Background: Asbestosis is a common pneumoconiosis caused by long-term asbestos exposure. Analysis of the burden of asbestosis would help in creating informed public health strategies.

  Methods: Data on asbestosis were analyzed using the Global Burden of Disease study 2019. The estimated annual percentage change (EAPC) was calculated to demonstrate temporal trends in the age-standardized rate (ASR) of asbestosis from 1990 to 2019.

  Results: Globally, 36,339 incident cases of asbestosis, led to 3572 deaths and 71,225 disability adjusted life years (DALYs) in 2019. During 1990-2019, the overall ASRs of incidence and DALYs declined by an annual average of 0.29 % and 0.27 %, with the respective EAPCs being -0.29 (95 % confidence interval [CI]: -0.43, -0.14) and -0.27 (95%CI: -0.53, -0.01). The ASRs of mortality increased with EAPC of 0.65 (95%CI: 0.34, 0.96). Trends in incidence and prevalence rose in females, but declined in males. The asbestosis burden was heterogeneous across regions and countries. The heaviest burden of asbestosis was observed in the United States, India, and China. Trends in ASRs of asbestosis varied across countries/territories. Pronounced increasing trends in incidence and prevalence occurred in Georgia, Iran, and Croatia.

  Conclusions: Decreasing incident trend of asbestosis was observed globally over the past three decades. However, the ongoing asbestosis burden highlighted that asbestosis remained a challenge to public health, and cost-effective measures were required to reduce the asbestosis burden.

  Copyright © 2023. Published by Elsevier B.V.

• Size characteristics of asbestiform fibers in lung tissue of animals that grazed in areas rich in ophiolitic outcrops in Central Calabria (Southern Italy). M.R. Bruno, A. Cannizzaro, A. Olori, et al. 2023;856(Pt 1):159061. PubMed · Publisher

  Abstract

  In Calabria (Southern Italy) naturally occurring asbestos (NOA) mainly occurs in the ophiolitic sequences cropping in the Mount Reventino area. The most common type of asbestos detected was the amphibole tremolite; fibrous antigorite and minor chrysotile were also found. The development of asbestos-related diseases depends on, among other things, the morphological characteristics of fibers, length and width, affecting the durability of asbestos fibers in the lung. In this work fifteen lung samples of sheep, goats and wild boars, grazing around the Mount Reventino area were collected and asbestos fibers analysed. Observed fibers (357), of which 97 % were tremolite and 3 % antigorite fibers, were grouped according to species, grazing area and age of the animals. The aim of this work was to highlight any differences among the groupings and to compare our size results with data in literature related to exposed populations. Principal Component Analysis (PCA) highlighted a positive correlation between tremolite fiber length and width and revealed groupings in terms of animal age. The Kruskal-Wallis test showed statistically significant differences between fiber mean widths in young and old animals. 63 % observed asbestiform fibers were longer than 5 μm and 7 % of the fibers were longer than 20 μm (critical fiber length connected to the frustrated phagocytosis by the macrophage). Fibers conforming to the Stanton Hypothesis size (predictor of the carcinogenic potency of fibers) were 1 %. Our size parameters of fibers detected in the animal lungs were in fairly good agreement with literature data for human asbestos exposure to tremolite. These results confirmed that an animal-sentinel system could be used to monitor the natural background of the airborne breathable fibers exposure. In addition, the size correlation of animal-human breathed fibers could be useful to study their potential toxicity. Additional data are necessary for improving the agreement with human exposure data.

  Copyright © 2022 Elsevier B.V. All rights reserved.

• Sustainable management of hazardous asbestos-containing materials: Containment, stabilization and inertization. S. Bolan, L. Kempton, T. McCarthy, et al. 2023;881:163456. Review PubMed · Publisher

  Abstract

  Asbestos is a group of six major silicate minerals that belong to the serpentine and amphibole families, and include chrysotile, amosite, crocidolite, anthophyllite, tremolite and actinolite. Weathering and human disturbance of asbestos-containing materials (ACMs) can lead to the emission of asbestos dust, and the inhalation of respirable asbestos fibrous dust can lead to 'mesothelioma' cancer and other diseases, including the progressive lung disease called 'asbestosis'. There is a considerable legacy of in-situ ACMs in the built environment, and it is not practically or economically possible to safely remove ACMs from the built environment. The aim of the review is to examine the three approaches used for the sustainable management of hazardous ACMs in the built environment: containment, stabilization, and inertization or destruction. Most of the asbestos remaining in the built environment can be contained in a physically secured form so that it does not present a significant health risk of emitting toxic airborne fibres. In settings where safe removal is not practically feasible, stabilization and encapsulation can provide a promising solution, especially in areas where ACMs are exposed to weathering or disturbance. Complete destruction and inertization of asbestos can be achieved by thermal decomposition using plasma and microwave radiation. Bioremediation and chemical treatment (e.g., ultrasound with oxalic acid) have been found to be effective in the inertization of ACMs. Technologies that achieve complete destruction of ACMs are found to be attractive because the treated products can be recycled or safely disposed of in landfills.

  Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

• There is plenty of asbestos at the bottom. The case of magnesite raw material contaminated with asbestos fibres. A.F. Gualtieri, D. Malferrari, D. Di Giuseppe, et al. 2023;898:166275. PubMed · Publisher

  Abstract

  Although all six asbestos minerals (the layer silicate chrysotile and five chain silicate species actinolite asbestos, amosite, anthophyllite asbestos, crocidolite and tremolite asbestos) are classified as carcinogenic, chrysotile is still mined and used in many countries worldwide. Other countries, like Italy, impose zero tolerance for all asbestos species, but conflicting views repress the development of globally uniform treaties controlling international trade of asbestos-containing materials. Hence, countries with more severe legislations against the use of these hazardous materials lack of an international safety net against importation of non-compliant products. This research reports the first discovery of commercial magnesite raw materials contaminated with white asbestos (chrysotile). X-ray powder diffraction and thermogravimetric/thermodifferential measurements showed the presence of serpentine group minerals in both the semi-processed (powder) and quarried material. The univocal identification of chrysotile in the powders was confirmed by its peculiar Raman bands of the OH stretching vibrations between 3500 and 3800 cm-1, with an intense peak at ∼3695 cm-1 and a weak contribution at ∼3647 cm-1. Transmission electron microscope showed that chrysotile forms fibres up to a few microns long and up to 80 nm thick with a nanotube structure characterized by inner channels as large as 30-40 nm. Fibres size analysis obtained by scanning electron microscopy indicates mean length and diameter of 5.95 and 0.109 μm with medians of 2.62 and 0.096 μm, respectively; some among the fibres analysed exhibit the so-called "Stanton size" (i.e., asbestos fibres longer than 8 μm and thinner than 0.25 μm that are strongly carcinogenic). Quantitative analysis showed a chrysotile content around 0.01 wt% not allowed by current regulations in Italy and many other countries. More generally, our findings demonstrate that without shared policies aimed at regulating asbestos circulation on the global market, "asbestos-free" national policies will inevitably fail.

  Copyright © 2023 Elsevier B.V. All rights reserved.

• Asbestos cement products and their impact on soil contamination in relation to various sources of anthropogenic and natural asbestos pollution. A. Obmiński. 2022;848:157275. PubMed · Publisher

  Abstract

  The results of a quantitative analysis of asbestos content in the ground with varying degrees of concentration of this mineral as a result of natural phenomena such as rock weathering, contamination by the manufacture of asbestos and cement products, and the many years of use of "eternit roofs" are presented. Preliminary thermal treatment, soil grinding and sieving were used for the determinations, followed by electrostatic separation in order to obtain the concentration of asbestos in a smaller volume. It was used for microscopic preparations for the identification and planimetry of asbestos. A polarizing optical microscope was used in the qualitative and quantitative analysis. The levels of re-emission of asbestos dust into the air as a result of the exploitation of contaminated soil were estimated. Polluted land in industrially areas, at a distance of up to 1200 m, contains 0.0003 % to 0.02 % asbestos. The content of 0.01 % asbestos does not require remediation in the absence of soil use. It may cause <500 fibres/m3. Removing the facade of asbestos-cement panels from the building at a distance of up to 10 m resulted in concentration <0.007 % of free asbestos in the ground, and for used roofs <0.001 % from above the distance of 3 m. This means that land in the vicinity of buildings with facade or roofing made of a-c products can be safely exploited. The direct discharge of rainwater from the gutter into the ground, however, contaminates it well above this value and those places should be treated as hazardous waste due to the presence of asbestos fibres in unbound form, containing <9,8 %. Ultimately, the size of the threat depends on many factors and can be comparable with the pollution of industrial production.

  Copyright © 2022 The Author. Published by Elsevier B.V. All rights reserved.

• Asbestos mining waste impacts on the sedimentological evolution of the Bécancour chain of lakes, southern Quebec (Canada). O. Jacques, R. Pienitz. 2022;807(Pt 3):151079. PubMed · Publisher

  Abstract

  More than a century (1877-2011 CE) of asbestos mining activities in the Thetford Mines region have resulted in the accumulation of gigantic mineral waste piles on the banks of the Bécancour River (southern Quebec, Canada). This river widens downstream from the mining sites to form a chain of lakes, successively: Stater Pond, Trout Lake, Lake William and Lake Joseph. A previous paleolimnological investigation revealed that waste erosion and transport strongly modified and polluted Trout Lake. However, questions remain about the extent of the mining contamination within the Bécancour River Basin and its impacts at other spatial scales. Here, we aimed to address this lack of knowledge by analyzing the sedimentological evolution of Stater Pond and lakes William, Joseph and Bécancour (upstream reference site). Radiometric dating (210Pb, 137Cs, 14C) and analyses of geochemical composition (ICP-AES/ICP-MS), computed tomography, magnetic susceptibility, loss-on-ignition and grain size were performed on sediment cores retrieved at these sites. In contrast to Lake Bécancour, yet similar to Trout Lake, we found that Stater Pond and Lake William have received high mineral matter loads since the creation of the Lake Asbestos Mine during the 1950s. Recent lake sediments at these downstream sites were highly enriched in magnesium, chromium and nickel. Comparison of their geochemical signature with that of sedimentary source materials from within the drainage basin demonstrated that they predominantly originate from mining waste erosion. Because of this issue, Stater Pond and lakes Trout and William are nowadays exposed to very high sediment accumulation rates (up to 1.4 cm yr-1; 0.6 g cm-2 yr-1) and heavy metal enrichment. Evidence for contamination was also found in Lake Joseph, indicating that wastes are transported and deposited over ≥25 km downstream from the mining sites. Our study highlights the high risks and dangers associated with asbestos pollutants in aquatic ecosystems.

  Copyright © 2021 Elsevier B.V. All rights reserved.

• Comparison of total PM emissions emitted from electric and internal combustion engine vehicles: An experimental analysis. S.H. Woo, H. Jang, S.B. Lee, et al. 2022;842:156961. PubMed · Publisher

  Abstract

  Electric vehicles (EVs) are regarded as zero emission vehicles due to the absence of exhaust emissions. However, they still contribute non-exhaust particulate matter (PM) emissions, generated by brake wear, tire wear, road wear, and resuspended road dust. In fact, because EVs are heavier than internal combustion engine vehicles (ICEVs), their non-exhaust emissions are like to be even higher. While total PM emissions, including exhaust and non-exhaust PM emissions, from ICEVs and EVs have been compared based on the emission factors (EFs) listed in national emission inventories, there have been no comparisons based on experimental determinations. In this study, exhaust and non-exhaust emissions generated from a gasoline ICEV, diesel ICEV, and EV were experimentally investigated. The results showed that the EFs for the total PM emissions of ICEVs and EV were dependent on the inclusion of secondary exhaust PM, the brake pad type, and the regenerative braking intensity of the EV. When only primary exhaust PM emissions were considered in vehicles equipped with non-asbestos organic (NAO) brake pads, the total PM10 EF of the EV (47.7-49.3 mg/V·km) was 10-17 % higher than those of the gasoline ICEV (42.3 mg/V·km) and diesel ICEV (43.2 mg/V·km). However, in vehicles equipped with low-metallic (LM) brake pads, the total PM10 EF of the EV (49.2-57.7 mg/V·km) was comparable or lower than those of the gasoline ICEV (56.3 mg/V·km) and diesel ICEV (57.2 mg/V·km). When secondary PM emissions were included, the EF was always significantly lower for the EV than ICEVs. The total PM10 EF of the EV (47.7-57.7 mg/V·km) was lower than those of the gasoline ICEV (56.5-70.5 mg/V·km) and diesel ICEV (58.0-72.0 mg/V·km). Since secondary PM particles are mostly of submicron size, the EFs of the PM2.5 fraction of the ICEVs (28.7-33.0 mg/V·km) were two times higher than those of the EV (13.9-17.4 mg/V·km).

  Copyright © 2022 Elsevier B.V. All rights reserved.

• Comprehensive evaluation of the possible impact of roofing materials on the quality of harvested rainwater for human consumption. B.M. Tengan, O. Akoto. 2022;819:152966. PubMed · Publisher

  Abstract

  Water is a vital natural resource that influences life and contributes to domestic and industrial activities. Availability and accessibility of safe water sources are crucial for a country's economic growth. Harvesting of roof runoffs is an alternative source of water used for domestic purposes. However, the quality of harvested rainwater can be affected by roofing materials. This research seeks to assess heavy metals concentration, physicochemical and bacteriological parameters in roof runoffs and estimate the water quality index and health risk these metals pose to consumers. Rainwater samples were collected from Aluzinc, Aluminum, Galvanized, and Asbestos roofing materials within the Ejisu municipality. Rainwater collected directly from the sky was used as control. All runoffs from the four roofing materials recorded Cd, Fe, Cr, turbidity, pH, E.coli, total and fecal coliform levels above WHO limit for drinking water. There was a significant variation in pH, EC, Zn, Cd, Cr, Fe, E. coli, total and fecal coliform levels between control samples and roof runoffs (p < 0.05). The estimated water quality index for runoffs from the four roofing materials exceeded 100 indicating their unsuitability for drinking. Cadmium recorded the highest non-cancer health risk to children and adults in all the roof runoffs. Hazard quotients (HQs) above one were recorded for a child (HQ = 40.1) and an adult (HQ = 13.6) via dermal exposure to Cd in runoff from Aluminum roofing material. Hazard quotient of 9.53 and 4.08 were estimated for a child and an adult respectively via oral exposure to Cd in runoffs from Asbestos roofing material. The estimated cancer risks were above 10-3 for a child and an adult via oral and dermal exposure to Cd in all roof runoffs, suggesting a possible cancer health effect. The study concludes that the four roofing materials impact negatively on the quality of runoffs.

  Copyright © 2022 Elsevier B.V. All rights reserved.

• Kinetics-informed global assessment of mine tailings for CO2 removal. L.A. Bullock, A. Yang, R.C. Darton. 2022;808:152111. PubMed · Publisher

  Abstract

  Chemically reactive mine tailings are a potential resource for drawing down carbon dioxide out of the atmosphere in mineral weathering schemes. Such carbon dioxide removal (CDR) systems, applied on a large scale, could help to meet internationally agreed targets for minimising climate change, but crucially we need to identify what materials could react fast enough to provide CDR at relevant climate change mitigation timescales. This study focuses on a range of silicate-dominated tailings, calculating their CDR potential from their chemical composition (specific capacity), estimated global production rates, and the speed of weathering under different reaction conditions. Tailings containing high abundances of olivine, serpentine and diopside show the highest CDR potential due to their favourable kinetics. We conclude that the most suitable tailings for CDR purposes are those associated with olivine dunites, diamond kimberlites, asbestos and talc serpentinites, Ni sulphides, and PGM layered mafic intrusions. We estimate the average annual global CDR potential of tailings weathered over the 70-year period 2030-2100 to be ~93 (unimproved conditions) to 465 (improved conditions) Mt/year. Results indicate that at least 30 countries possess tailings materials that, under improved conditions, may offer a route for CDR which is not currently utilised within the mining industry. By 2100, the total cumulative CDR could reach some 33 GtCO2, of which more than 60% is contributed by PGM tailings produced in Southern Africa, Russia, and North America. The global CDR potential could be increased by utilization of historic tailings and implementing measures to further enhance chemical reaction rates. If practical considerations can be addressed and enhanced weathering rates can be achieved, then CDR from suitable tailings could contribute significantly to national offset goals and global targets. More research is needed to establish the potential and practicality of this technology, including measurements of the mineral weathering kinetics under various conditions.

  Copyright © 2021 Elsevier B.V. All rights reserved.

• ATR-FTIR and LC-Q-ToF-MS analysis of indoor dust from different micro-environments located in a tropical metropolitan area. M. Vishnu Sreejith, K.S. Aradhana, M. Varsha, et al. 2021;783:147066. PubMed · Publisher

  Abstract

  Indoor dust is an important matrix that exposes humans to a broad spectrum of chemicals. The information on the occurrence of contaminants of emerging concern (CECs), their metabolites, and re-emerging contaminants in indoor dust is rather limited. As the indoor environment is exposed to various chemicals from personal care products, furniture, building materials, machineries and cooking/cleaning products, there is a high chance of the presence of hazardous contaminants in indoor dust. In the present study, dust samples were collected from four different micro indoor environments (photocopying centres, residential houses, classrooms, and ATM cabins) located in an urban environment located in India's southwestern part. The collected samples were subjected to ATR - FTIR and LC-Q-ToF-MS analyses. The ATR - FTIR analysis indicated the presence of aldehydes, anhydrides, carboxylic acids, esters, sulphonic acids, and asbestos - a re-emerging contaminant. A total of 19 compounds were identified from the LC-Q-ToF-MS analysis. These compounds belonged to various classes such as plasticisers, plasticiser metabolites, photoinitiators, personal care products, pharmaceutical intermediates, surfactants, and pesticides. To the best of our knowledge, this is the first report regarding the presence of CECs in indoor environments in Kerala and also the suspected occurrence of pesticides (metaldehyde and ethofumesate) in classroom dust in India. Another important highlight of this work is the demonstration of ATR-FTIR as a complementary technique for LC-Q-ToF-MS in the analysis of indoor pollution while dealing with totally unknown pollutants. These results further highlight the occurrence of probable chemically modified metabolites in the tropical climatic conditions in a microenvironment.

  Copyright © 2021. Published by Elsevier B.V.

• Airborne fiber particles: Types, size and concentration observed in Beijing. Y. Li, L. Shao, W. Wang, et al. 2020;705:135967. PubMed · Publisher

  Abstract

  Airborne fibers are of public concern because of their potential threat to the environment, however their physical and chemical properties are poorly understood. Fibers are defined as having an aspect ratio >3:1. Fiber particles were collected in the near surface air, surface deposited dust and building materials in Beijing. They were examined using analytical scanning electron microscopy. The particles were initially classified into two categories: organic and inorganic. Organic fibers comprised microplastic and natural organic fiber particles. Inorganic fibers were mainly man-made mineral fibers (MMMFs), asbestos (represented by chrysotile), calcium sulfate and metal fiber particles. Microplastic and MMMFs fibers were most abundant, accounting for 34.6% and 40.3% in total, respectively, followed by asbestos (7.8%), calcium sulfate (7.2%), metal fibers (5.6%) and natural organic fiber particles (4.5%). The number-concentration of these particles was about 16.7 × 10-3 fibers/ml at 1.5 m above the ground and about 14.1 × 10-3 fibers/ml at about 18 m, suggesting the particles were mainly derived from surface and were re-suspended. Approximately 80% of the airborne fiber were smaller than 20 μm in length, which is possibly the critical size for fiber particles to re-suspend into the air. Surface dust and construction sites were speculated to be the major contributors of the fiber particles.

  Copyright © 2019 Elsevier B.V. All rights reserved.

• Asbestos-containing materials in abandoned residential dwellings in Detroit. A. Franzblau, A.H. Demond, S.K. Sayler, et al. 2020;714:136580. PubMed · Publisher · Free full text

  Abstract

  Objective: The efforts of many municipalities to demolish abandoned residential dwellings (ARDs) are hampered by the presence of asbestos-containing materials (ACMs) in these structures. However, the extent of such materials is unknown. Our study sought to characterize ACMs present in ARDs demolished in Detroit.

  Methods: Working with the City of Detroit, we obtained information on all ARDs demolished from 2014 to 2017. We randomly sampled 605 ARDs and analyzed the presence, type, and amount of ACM present, and the associated abatement and demolition costs.

  Results: Asbestos was present in about 95% of the sampled ARDs. The most common types of ACMs were flooring, roofing, siding, and duct insulation. The material containing the greatest fraction of asbestos was duct insulation. The type of asbestos generally present was chrysotile. Only eight (1%) ARDs contained commercial amphibole asbestos; another 36 contained vermiculite. The total cost of demolition averaged $13,645 per home, of which 20.1% was asbestos abatement.

  Conclusions: The majority of the ACM in the ARDs was nonfriable and consisted of chrysotile. This study contributes information about the nature and extent of ACM in ARDs, which can provide part of the foundation for making an assessment of possible asbestos-containing air emissions during the demolitions of ARDs, and the nature or extent of pre-demolition abatement that may be needed (if any) to protect the public's health.

  Copyright © 2020 Elsevier B.V. All rights reserved.

• Environmental contamination by naturally occurring asbestos (NOA): Analysis of sentinel animal lung tissue. A. Campopiano, A. Cannizzaro, A. Olori, et al. 2020;745:140990. PubMed · Publisher

  Abstract

  Ophiolites are known sources of naturally occurring asbestos (NOA). In Calabria (Southern Italy) NOA are mainly concentrated in the ophiolitic sequences cropping in the Mount Reventino area, in the southern part of the Sila massif, and along the Coastal Chain. The most common type of asbestos identified in the rocks of these areas belongs to the tremolite-actinolite series. Another identified asbestiform mineral is fibrous antigorite belonging to the serpentine mineral group with a minor amount of chrysotile. The purpose of the present study is to evaluate the diffusion of natural asbestiform fibers from NOA using sentinel animals. Fifteen lung samples of sheep, goats and wild boars from Mount Reventino area and two from an area free from NOA were collected. The lung samples were subjected to anatomopathological examination and lung fiber burden analysis by electron microscopy. Abundant tremolite and few antigorite fibers were detected in the lung samples coming from the NOA area. No corpuscle of asbestos was observed. No fiber was found in the two lung samples of sheet from the area free from NOA. These concentrations of fibers per gram of dry weight of lung tissue (f/gdw) ranged from 104 to 106 f/gdw. The asbestos fibers detected in the lungs of the examined animals reflect the geological features of the areas where they grazed and lived. The anatomopathological analysis showed that 60% of the examined animals had macroscopic lesions affecting their lungs. The presence of tremolite fibers in the lungs confirms the diffusion of mineral fibers in the environment and the real advantage of using animal populations in the study areas.

  Copyright © 2020 Elsevier B.V. All rights reserved.

• Flocking asbestos waste, an iron and magnesium source for Pseudomonas. S.R. David, S. Fritsch, A. Forster, et al. 2020;709:135936. PubMed · Publisher

  Abstract

  Iron and magnesium are essential nutrients for most microorganisms. In the environment, the availability of iron is low relative to that of magnesium. Microorganisms have developed various iron acquisition systems, which have been well studied, whereas few studies have examined magnesium acquisition. The production of siderophores is one of the efficient strategies widely used to sustain iron nutritional requirements. Many studies have shown that minerals, such as clays, iron oxides, and silicates, can serve as nutrient sources for bacteria. Asbestos, a natural fibrous silicate present in soil contains iron and/or magnesium, depending on the species of asbestos. Our aim was to study the acquisition of iron and magnesium from flocking asbestos waste by Pseudomonas aeruginosa and the involvement of the siderophores, pyoverdine and pyochelin. Flocking asbestos waste promoted growth under iron- and magnesium-limited conditions, together with a decrease in pyoverdine production, correlating with the dissolution of iron from the waste. In long-term experiments, flocking asbestos waste provided these two essential elements for bacterial growth and resulted in a decrease of iron in asbestos fibers. Among the enzymes required for pyochelin and pyoverdine synthesis, PchA and PvdJ were tagged with the fluorescent protein mCherry to analyze the expression patterns of proteins involved in siderophore production. Both enzymes were produced in the presence of flocking asbestos waste, suggesting a role of the pyoverdine and pyochelin pathway in asbestos dissolution. We investigated the involvement of each siderophore in iron and magnesium removal using mutants in one or both siderophore pathways. We observed a significant increase in iron extraction in the presence of siderophores and the absence of one of the two siderophores could be compensated by the other. Flocking asbestos waste represents an iron and magnesium source for P. aeruginosa, with iron removal linked to a siderophore-driven mechanism.

  Copyright © 2019 Elsevier B.V. All rights reserved.

• Human exposure to trace elements and PCDD/Fs around a hazardous waste landfill in Catalonia (Spain). M. Herrero, J. Rovira, M. Marquès, et al. 2020;710:136313. PubMed · Publisher

  Abstract

  Hazardous waste landfills (HWLs) usually mean the end of non-reusable, non-recyclable and non-recoverable wastes derived from industrial activities. A number of hazardous compounds and toxic elements, such as PCDD/Fs, Cd, Cr, Hg, Pb and As, is associated to these wastes. The HWL of Castellolí (Catalonia, Spain) treats a variety of hazardous wastes, which include bottom ashes from waste incinerators and asbestos potentially containing those toxicants. In 2007, our group began a surveillance program inside the HWL and in nearby villages focused on assessing the environmental levels of PCDD/Fs and toxic elements. Here we summarize the most updated results, corresponding to data from samples collected between 2015 and 2018. The levels of most trace elements (As, Cd, Cr, Ni and Pb) in soils, as well as those of Cd and Pb in air, were significantly higher (p < 0.01) inside the HWL than outside. However, no relevant differences were noted in the concentrations of trace elements when comparing the results of villages near the HWL with those located farther. With respect to PCDD/Fs, a progressive decrease was observed between the first (2007) and most recent (2018) surveys. The human health risks associated with the exposure to trace elements and PCDD/Fs exposure were within acceptable ranges according to national and international legislations (HQ < 1 and Cancer risk < 10-5).

  Copyright © 2019 Elsevier B.V. All rights reserved.

• Identifying predictors of personal exposure to air temperature in peri-urban India. C. Milà, A. Curto, A. Dimitrova, et al. 2020;707:136114. PubMed · Publisher

  Abstract

  Characterizing personal exposure to air temperature is critical to understanding exposure measurement error in epidemiologic studies using fixed-site exposure data and to identify strategies to protect public health. To date, no study evaluating personal air temperature in the general population has been conducted in a low-and-middle income country. We used data from the CHAI study consisting of 50 adults monitored in up to six non-consecutive 24 h sessions in peri-urban south India. We quantified the agreement and association between fixed-site ambient and personal air temperature, and identified predictors of personal air temperature based on housing assessment, self-reported, GPS, remote sensing, and wearable camera data. Mean (SD) daytime (6 am-10 pm) average personal air temperature was 31.2 (2.6) °C and mean nighttime (10 pm-6 am) average temperature was 28.8 (2.8) °C. Agreement between average personal air and fixed-site ambient temperatures was limited, especially at night when personal air temperatures were underestimated by fixed-site temperatures (MBE = -5.6 °C). The proportion of average personal nighttime temperature variability explained by ambient fixed-site temperatures was moderate (R2mar = 0.39); daytime associations were stronger for women (R2mar = 0.51) than for men (R2mar = 0.3). Other predictors of average nighttime personal air temperature included residential altitude, ceiling height, and household income. Predictors of average daytime personal air temperature included roof materials, GPS-tracked altitude, time working in agriculture (for women), and time travelling (for men). No biomass cooking, urban heat island, or greenspace effects were identified. R2mar between ambient fixed-site and personal air temperature indicate that ambient fixed-site temperature is only a moderately useful proxy of personal air temperature in the context of peri-urban India. Our findings suggest that people living in houses at lower altitude, with lower ceiling height and asbestos roofing sheets might be more vulnerable to heat. We also identified households with higher income, women working in agriculture and men with long commutes as disproportionately exposed to high temperatures.

  Copyright © 2019. Published by Elsevier B.V.

• Letter to Editor regarding Franzblau et al. 2020: Asbestos-containing materials in abandoned residential dwellings in Detroit, Science of Total Environment, v714,1-8. A.L. Frank. 2020;739:139129. Letter · Comment PubMed · Publisher

• Measurement of asbestos emissions associated with demolition of abandoned residential dwellings. R.L. Neitzel, S.K. Sayler, A.H. Demond, et al. 2020;722:137891. PubMed · Publisher · Free full text

  Abstract

  Many cities are revitalizing their urban cores through the demolition of abandoned residential dwellings (ARDs). However, data regarding the emissions of asbestos during such an operation are sparse. We measured airborne asbestos emissions from emergency demolitions (demolitions on structures deemed too dangerous to enter and remove asbestos) of ARDs in Detroit. High-flow air sampling was conducted during ARD demolitions. Air samples were analyzed using Phased Contrast Microscopy (PCM), and a subset using Transmission Electron Microscopy (TEM). One hundred and one air samples were collected on 25 emergency demolitions. Fifty-four of the 101 PCM samples (53%) exceeded the limit of detection (LOD). However, only 2 of 46 TEM samples (4%) exceeded the LOD for asbestos; these latter samples were from two different demolitions and each contained a single chrysotile asbestos fiber. Using conservative exposure assumptions and commonly-accepted risk estimation formulae, we estimated the lifetime risk of mesothelioma and lung cancer combined to be less than one case per one million people. Emissions of airborne asbestos during emergency (unabated) ARD demolition operations appear to be negligible. As a result, the associated health risk for asbestos-related disease is also negligible. Reconsideration of current regulatory mandates for asbestos abatement in ARDs may be warranted.

  Copyright © 2020 Elsevier B.V. All rights reserved.

• Occurrence, behaviour, and human exposure pathways and health risks of toxic geogenic contaminants in serpentinitic ultramafic geological environments (SUGEs): A medical geology perspective. W. Gwenzi. 2020;700:134622. Review PubMed · Publisher

  Abstract

  Serpentinitic ultramafic geological environments (SUGEs) contain toxic geogenic contaminants (TGCs). Yet comprehensive reviews on the medical geology of SUGEs are still lacking. The current paper posits that TGCs occur widely in SUGEs, and pose human health risks. The objectives of the review are to: (1) highlight the nature, occurrence and behaviour of TGCs associated with SUGEs; (2) discuss the human intake pathways and health risks of TGCs; (4) identify the key risk factors predisposing human health to TGCs particularly in Africa; and (5) highlight key knowledge gaps and future research directions. TGCs of human health concern in SUGEs include chrysotile asbestos, toxic metals (Fe, Cr, Ni, Mn, Zn, Co), and rare earth elements. Human intake of TGCs occur via inhalation, and ingestion of contaminated drinking water, wild foods, medicinal plants, animal foods, and geophagic earths. Occupational exposure may occur in the mining, milling, sculpturing, engraving, and carving industries. African populations are particularly at high risk due to: (1) widespread consumption of wild foods, medicinal plants, untreated drinking water, and geophagic earths; (2) weak and poorly enforced environmental, occupational, and public health regulations; and (3) lack of human health surveillance systems. Human health risks of chrysotile include asbestosis, cancers, and mesothelioma. Toxic metals are redox active, thus generate reactive oxygen species causing oxidative stress. Dietary intake of iron and geophagy may increase the iron overload among native Africans who are genetically predisposed to such health risks. Synergistic interactions among TGCs particularly chrysotile and toxic metals may have adverse human health effects. The occurrence of SUGEs, coupled with the several risk factors in Africa, provides a unique and ideal setting for investigating the relationships between TGCs and human health risks. A conceptual framework for human health risk assessment and mitigation, and future research direction are highlighted.

  Copyright © 2019 Elsevier B.V. All rights reserved.

• Response to Letter to the Editor regarding Franzblau et al., Asbestos-containing materials in abandoned residential dwellings in Detroit, from Prof. Arthur Frank, MD, PhD. A. Franzblau, A.H. Demond, S.K. Sayler, et al. 2020;739:139165. Letter · Comment PubMed · Publisher

• Wild rats as urban detectives for latent sources of asbestos contamination. F. Ingravalle, L.A. Ceballos, V. D'Errico, et al. 2020;729:138925. PubMed · Publisher

  Abstract

  Based on a large body of evidence asbestos minerals have been classified as carcinogens. Despite the Italian ban on asbestos in 1992 and the subsequent remediation activities, latent sources of contamination may still represent a hazard where asbestos were particularly used. Using wild rats as sentinel animals, this study aimed at uncovering sites with the greatest potential for non-occupational exposure to asbestos in the city of Casale Monferrato (Piedmont Region, Italy), where the largest Italian manufacturing plant of asbestos-cement had been active. During the study period (2013-2015) a total of 40 wild rats were captured from 16 sampling capture points. The lungs of wild rats have been investigated by using scanning electron microscopy (SEM) with energy dispersive spectroscopy (EDS). The SEM-EDS detected the presence of asbestos fibers (tremolite/actinolite, amosite, and chrysotile) in rats' lungs from 11 sampling points. The hypothetical rats' home-range and the observed site-specific concentration of asbestos fibers per gram of dry lung tissue were used to identify areas to be targeted by additional search of latent sources of asbestos. In conclusion, our results showed that the use of wild rats as sentinel animals may effectively integrate the strategies currently in use to reduce the exposure to asbestos.

  Copyright © 2020 Elsevier B.V. All rights reserved.

• X-ray synchrotron microtomography: a new technique for characterizing chrysotile asbestos. A. Bloise, C. Ricchiuti, G. Lanzafame, et al. 2020;703:135675. PubMed · Publisher

  Abstract

  Over the last decades, many studies have been conducted on rocks containing Naturally Occurring Asbestos (NOA) to determine the potential health risks to exposed neighboring populations. It is difficult to accurately characterize the asbestos fibres contained within the rocks as conventional techniques are not effective and have drawbacks associated with the disturbance of the sample under study. X-ray synchrotron microtomography (SR-μCT) supplemented with polarized light microscope (PLM), scanning electron microscopy analysis combined with energy dispersive spectrometry (SEM/EDS), electron probe micro-analysis (EPMA) were used for identifying asbestos fibres in a mineral matrix. As a case study, we analyzed a representative set of veins and fibrous chrysotile that fills the veins, taken from massive serpentinite outcrops (Southern-Italy). We were able to identify respirable chrysotile fibres (regulated asbestos) within the serpentinite matrix. SR-μCT of NOA veins achieved the resolution and reconstructed 3D structures of infill chrysotile asbestos fibres and other phase structures that were not resolvable with PLM, SEM or EPMA. Moreover, due to differences in chemical composition between veins and matrix, the data obtained enabled us to evaluate the vein shapes present in the massive serpentinite matrix. In particular, iron and aluminum distribution variations between veins and matrix induce different radiation absorption patterns thus permitting a detailed image-based 3D geometric reconstruction. The advantages of the SR-μCT technique as well as limitation of conventional methods are also discussed. These analytical approaches will be used for conducting future research on NOA of other minerals, which exhibit asbestiform and non-asbestiform habits within veins, including asbestos amphiboles.

  Copyright © 2019 Elsevier B.V. All rights reserved.

2010s

• Malignant peritoneal mesothelioma in a boar who lived in Calabria (Italy): Wild animal as sentinel system of human health. E. Colombino, S. Capella, F. Casalinuovo, et al. 2019;683:267-274. PubMed · Publisher

  Abstract

  Mesothelioma is a tumor of the serosal membranes described both in human and veterinary medicine. While in humans the relationship between mesothelioma and exposure to asbestos and some other asbestiform minerals is well known, in animals it is still difficult to establish. In this paper a case of malignant peritoneal mesothelioma probably related to asbestos exposure in a wild boar is described. At post-mortem evaluation the peritoneum, diaphragm and serosal surface of liver and kidneys showed isolated to coalescent multiple nodular lesions. Samples from diaphragm, liver and lung were collected to perform microbiological and histological investigations. To assess the presence of asbestos and/or other asbestiform minerals, SEM-EDS investigations were performed on organs and soil samples collected from the area where the wild boar lived. Microbiological investigations were negative for Mycobacterium species. Gross and histological examination were compatible with a biphasic mesothelioma, with nodules composed of epithelioid and sarcomatoid elements with high pleomorphism. Immunohistochemistry revealed only multifocal scattered positivity for WT-1 and D2-40. Asbestos fibres were detected in all samples (organs and soil) by SEM-EDS, demonstrating a potential relationship between the neoplasia and the exposure to naturally occurring asbestos (NOA). In conclusion, the results of the present study are further confirmation that wild animals, such as the boar, are suitable sentinels to indicate the risk of environmental exposure to asbestos for human populations.

  Copyright © 2019 Elsevier B.V. All rights reserved.

• Sociodemographic predictors of residents worry about contaminated sites. E. McIntyre, J. Prior, I.L.C. Connon, et al. 2018;643:1623-1630. PubMed · Publisher

  Abstract

  The management and remediation of contaminated environments increasingly involves engagement with affected local residents. Of late, risk communication tools and guidelines have drawn attention to the stress and concern of residents as a result of heightened awareness of localised contamination and the need to address these less visible impacts of contamination when engaging with affected communities. Despite this emerging focus, there is an absence of research exploring the factors that predict resident worry about neighbourhood contamination. This paper aims to address this shortcoming by drawing on data from a cross-sectional survey of 2009 adult residents in neighbourhoods near 13 contaminated sites across Australia. Analyses used ordered logistic regression to determine the sociodemographic, environmental, and knowledge-based factors that influence residents' degree of worry. The findings suggest age, gender and income significantly affect residents' degree of worry. Being knowledgeable about the contaminant was associated with lower degrees of worry. Conversely, having a stronger sense of place within a neighbourhood predicted higher degrees of worry. Type of contaminant also impacted resident worry, with residents being less likely to worry about hydrocarbon, asbestos and waste than other types of contaminants. Our analyses suggest resident worry can be reduced through improving access to accurate information and the development of specific risk reduction strategies tailored to each neighbourhood and aimed at the heterogeneous distribution of worry amongst residential populations.

  Copyright © 2018 Elsevier B.V. All rights reserved.

• Predicting the mortality from asbestos-related diseases based on the amount of asbestos used and the effects of slate buildings in Korea. S.Y. Kim, Y.C. Kim, Y. Kim, et al. 2016;542(Pt A):1-11. PubMed · Publisher

  Abstract

  Asbestos has been used since ancient times, owing to its heat-resistant, rot-proof, and insulating qualities, and its usage rapidly increased after the industrial revolution. In Korea, all slates were previously manufactured in a mixture of about 90% cement and 10% chrysotile (white asbestos). This study used a Generalized Poisson regression (GPR) model after creating databases of the mortality from asbestos-related diseases and of the amount of asbestos used in Korea as a means to predict the future mortality of asbestos-related diseases and mesothelioma in Korea. Moreover, to predict the future mortality according to the effects of slate buildings, a comparative analysis based on the result of the GPR model was conducted after creating databases of the amount of asbestos used in Korea and of the amount of asbestos used in making slates. We predicted the mortality from asbestos-related diseases by year, from 2014 to 2036, according to the amount of asbestos used. As a result, it was predicted that a total of 1942 people (maximum, 3476) will die by 2036. Moreover, based on the comparative analysis according to the influence index, it was predicted that a maximum of 555 people will die from asbestos-related diseases by 2031 as a result of the effects of asbestos-containing slate buildings, and the mortality was predicted to peak in 2021, with 53 cases. Although mesothelioma and pulmonary asbestosis were considered as asbestos-related diseases, these are not the only two diseases caused by asbestos. However the results of this study are highly important and relevant, as, for the first time in Korea, the future mortality from asbestos-related diseases was predicted. These findings are expected to contribute greatly to the Korean government's policies related to the compensation for asbestos victims.

  Copyright © 2015 Elsevier B.V. All rights reserved.

• Evidence of arsenic release promoted by disinfection by-products within drinking-water distribution systems. S.S. Andra, K.C. Makris, G. Botsaris, et al. 2014;472:1145-51. PubMed · Publisher

  Abstract

  Changes in disinfectant type could trigger a cascade of reactions releasing pipe-anchored metals/metalloids into finished water. However, the effect of pre-formed disinfection by-products on the release of sorbed contaminants (arsenic-As in particular) from drinking water distribution system pipe scales remains unexplored. A bench-scale study using a factorial experimental design was performed to evaluate the independent and interaction effects of trihalomethanes (TTHM) and haloacetic acids (HAA) on arsenic (As) release from either scales-only or scale-biofilm conglomerates (SBC) both anchored on asbestos/cement pipe coupons. A model biofilm (Pseudomonas aeruginosa) was allowed to grow on select pipe coupons prior experimentation. Either TTHM or HAA individual dosing did not promote As release from either scales only or SBC, detecting <6 μg AsL(-1) in finished water. In the case of scales-only coupons, the combination of the highest spike level of TTHM and HAA significantly (p<0.001) increased dissolved and total As concentrations to levels up to 16 and 95 μg L(-1), respectively. Similar treatments in the presence of biofilm (SBC) resulted in significant (p<0.001) increase in dissolved and total recoverable As up to 20 and 47 μg L(-1), respectively, exceeding the regulatory As limit. Whether or not, our laboratory-based results truly represent mechanisms operating in disinfected finished water in pipe networks remains to be investigated in the field.

  Copyright © 2013 Elsevier B.V. All rights reserved.

• The wild rat as sentinel animal in the environmental risk assessment of asbestos pollution: a pilot study. M. Ardizzone, C. Vizio, E. Bozzetta, et al. 2014;479-480:31-8. PubMed · Publisher

  Abstract

  Asbestos has been banned in many countries, including Italy. However, sources of exposure may still exist, due to asbestos in-situ or past disposal of asbestos-containing waste. In an urban area with past high environmental exposure, like Casale Monferrato, the lung fiber burden in sentinel animals may be useful to identify such sources. A pilot study was conducted to assess the feasibility of its determination in wild rats, a suitable sentinel species never used before for environmental lung asbestos fiber burden studies. Within the framework of pest control campaigns, 11 adult animals from 3 sites in the urban area of Casale Monferrato and 3 control rats from a different, unexposed town were captured. Further, 3 positive and 3 negative control lung samples were obtained from laboratories involved in breeding programs and conducting experimental studies on rats. Tissue fiber concentration was measured by scanning electron microscopy with energy dispersive spectrometry. Asbestos (chrysotile and crocidolite) was identified in the lungs from rats from Casale Monferrato, but not in control rats and in negative control lung samples. Asbestos grunerite at high concentration was found in positive control lung samples. Measurement of the lung fiber burden in wild rats has proved feasible: it was possible not only to detect, but also to characterize asbestos fibers both qualitatively and quantitatively. The pilot study provides the rationale for using wild rats as sentinels of the soil contamination level in Casale Monferrato, to identify areas with the possible presence of previously unrecognized asbestos sources.

  Copyright © 2014 Elsevier B.V. All rights reserved.

• Necessity and approach to integrated nanomaterial legislation and governance. J. Wang, J.D. Gerlach, N. Savage, et al. 2013;442:56-62. PubMed · Publisher

  Abstract

  Nanotechnology is one of the most promising technologies to emerge in recent decades. Materials that are specially engineered to have at least one dimension that is no larger than 100 nm are now continuously manufactured and incorporated as critical components of different products that people use daily. While we are taking advantage of nanomaterials (NMs) and nano-products, they may pose a risk to humans and the broader environment. Some types of fibrous NMs such as carbon nanotubes and nano-fibers may present a risk similar to that of asbestos. Some carbon or metal based NMs may threaten the environment due to their bioaccumulative nature within food webs. In order to prevent future adverse effects from products or byproducts of nanotechnology, we suggest an integrated multi-faceted approach which includes an integrated regulation that is based upon life cycle assessment, empirically derived risk assessment. Advanced research that fills the knowledge gap regarding the understanding of NMs in scientific and social norms will be helpful in a full life cycle assessment of NMs. Emphasizing nanotechnology education to the public for an increased understanding and participation associated with media coverage will finally draw governments' attention with an integrated legislation to be instituted. Developing the optimal mix of these tools, including research, public education, media coverage, integrated legislation, will be significant to proactively manage the complexity of nanotechnology and prevent any undesirable effect due to the NMs exposure.

  Copyright © 2012 Elsevier B.V. All rights reserved.

• Industrial pollution and pleural cancer mortality in Spain. G. López-Abente, P. Fernández-Navarro, E. Boldo, et al. 2012;424:57-62. PubMed · Publisher

  Abstract

  Pleural cancer mortality is an acknowledged indicator of exposure to asbestos and mesothelioma mortality but in 15%-20% of cases no exposure can be recalled. In the past, asbestos was used in many industries and it is still found in many installations. Our objective was to ascertain whether there might be excess pleural cancer mortality among populations residing in the vicinity of Spanish industrial installations that are governed by the Integrated Pollution Prevention and Control (IPPC) Directive and the European Pollutant Release and Transfer Register Regulation and report their emissions to air. An ecological study was designed to examine pleural cancer mortality at a municipal level (8098 Spanish towns) over the period 1997-2006, during which 2146 deaths were registered. We conducted an exploratory "near vs. far" analysis to estimate the relative risks (RRs) of towns situated at a distance of <2 km from installations. This analysis was repeated for each of the 24 industrial groups. RR and their 95% credible intervals (95% CIs) were estimated on the basis of a Poisson conditional autoregressive Bayesian model with explanatory variables. Integrated nested Laplace approximations were used as a Bayesian inference tool. Analysis showed statistically significant RRs in both sexes in the vicinity of 7 of the 24 industrial groups studied (RR, 95% CI), namely, biocide facilities (2.595, 1.459-4.621), ship-building (2.321, 1.379-3.918), glass and mineral fibre production (1.667, 1.041-2.665), non-hazardous waste treatment (1.737, 1.077-2.799), galvanising (1.637, 1.139-2.347), organic chemical plants (1.386, 1.075-1.782) and the food and beverage sector (1.255, 1.006-1.562). In the proximity of sources pertaining to the biocide, organic chemical and galvanising sectors, the risk was seen to be rising among men and women, a finding that could indicate airborne environmental exposure. These results support that residing in the vicinity of IPPC-registered industries that release pollutants to the air constitutes a risk factor for pleural cancer.

  Copyright © 2012 Elsevier B.V. All rights reserved.

• Resistance to asbestos-induced apoptosis with continuous exposure to crocidolite on a human T cell. M. Maeda, S. Yamamoto, Y. Chen, et al. 2012;429:174-82. PubMed · Publisher

  Abstract

  We have been investigating the immunological effects of asbestos. The establishment of a low-dose and continuously exposed human T cell line, HTLV-1 immortalized MT-2, to chrysotile (CB) revealed reduction of CXCR3 chemokine receptor and production of IFN-γ that caused a decline of tumor immunity. These effects were coupled with upregulation of IL-10, TGF-β, and BCL-2 in asbestos-exposed patients. To observe the immunological effects of crocidolite (CR) on human T cells, a trial to establish a low-dose and continuously exposed model was conducted and compared with a previously reported CB-exposed model (MT-2CB). Transient exposure of MT-2 original cells to CB or CR induced a similar level of apoptosis and growth inhibition. The establishment of a continuously exposed subline to CR (MT-2CR) revealed resistance against CR-induced apoptosis and upregulation of the BCL-2/BAX ratio similar to that recorded for MT-2CB. Both sublines showed reduced production of IFN-γ, TNF-α, and IL-6 with increased IL-10. cDNA microarray with network/pathway analyses focusing on transcription factors revealed that many similar factors related to cell proliferation were involved following continuous exposure to asbestos in both MT-2CB and MT-2CR. These results indicate that both CB and CR fibers affect human T cells with similar degrees even though the carcinogenic activity of these substances differs due to their chemical and physical forms. Trials to identify early detection markers for asbestos exposure or the occurrence of asbestos-inducing malignancies using these findings may lead to the development of clinical tools for asbestos-related diseases and chemoprevention that modifies the reduced tumor immunity.

  Copyright © 2012 Elsevier B.V. All rights reserved.

2000s

• Environmental exposure to asbestos and other inorganic fibres using animal lung model. E. Fornero, E. Belluso, S. Capella, et al. 2009;407(3):1010-8. PubMed · Publisher

  Abstract

  Professional exposure to asbestos fibres is widely recognized as very dangerous to human health and for this reason many countries have banned their commercial uses. People, nevertheless, continue to be exposed to low dose of asbestos from natural and anthropogenic sources still in loco, for which the potential hazard is unknown. The aim of this research is to assess environmental exposure in an area with outcropping serpentinite rocks, which bear asbestos mineralizations, using sentinel animals which are a non-experimental animal model. We studied the burden of inorganic fibres in cattle lungs which come from two areas in Italy's Western Alps bearing serpentinitic outcrops: Susa Valley with a heavy anthropization and Lanzo Valleys, with a minor human impact. The identification and quantification of inorganic fibres were performed by Scanning Electron Microscope (SEM) and Energy Dispersive Spectrometer (EDS). In comparison to humans, studies of animals have some advantages, such as no occupational exposure or history of smoking and, in the case of cattle, a sedentary life restricted to one region. Results spotlight that over than 35% of inorganic fibres found both in Susa and Lanzo valleys, belong to asbestos mineralogical species (asbestos tremolite/actinolite, chrysotile s.s., asbestos grunerite, crocidolite). We also observed a higher concentration of artificial fibrous products in Susa samples showing a correlation with the level of anthropization. These results confirm that sentinel animals are an excellent model to assess breathable environmental background because it is possible to eliminate some variables, such as unknown occupational exposure.

• Utilization of the seagrass Posidonia oceanica to evaluate the spatial dispersion of metal contamination. C. Lafabrie, G. Pergent, C. Pergent-Martini. 2009;407(7):2440-6. PubMed · Publisher

  Abstract

  Metal concentrations have been measured in blades of the endemic Mediterranean seagrass Posidonia oceanica, along transects from three different contaminant point sources (the former asbestos mine of Canari - Corsica, France; the chemical plant of Solvay/Rosignano - Livorno, Italy; and the industrial harbour of Porto-Torres - Sardinia, Italy). The aim of this study was to evaluate the spatial extent of the impact of these sources in terms of metal contamination. The results showed that metal contamination from the former mine of Canari (cobalt - Co, chromium - Cr and nickel - Ni) extends at least 5 km to the north and south. The impact of this mine, which closed in 1965, seems to be lingering still. Mercury (Hg) contamination in the Livorno location was difficult to evaluate due to the presence of others potential sources of mercury in the area (e.g. industrialized city of Livorno, natural cinnabar deposits, intense tectonic activity of the area). At any rate, mercury concentration decreased strongly with distance from the plant. Lead (Pb) contamination at the Porto-Torres harbour was very low and disappeared with distance from the harbour. However, as the Porto-Torres harbour does not appear as a substantial point source of Pb contamination and because of the ubiquitous characteristic of the Pb element, it is difficult to draw any general conclusions concerning this element. The results presented in this study demonstrated the usefulness of the seagrass P. oceanica as a tool for the evaluation of the spatial extent of metal contaminations from point sources and could, therefore, contribute to on-going efforts to manage coastal environments.

• Nature and extent of the exposure to fibrous amphiboles in Biancavilla. B.M. Bruni, A. Pacella, S. MazziottiTagliani, et al. 2006;370(1):9-16. PubMed · Publisher

  Abstract

  An epidemiological and environmental study in the Biancavilla area (Sicily, Italy) was recently prompted by an impressively high incidence of malignant pleural mesothelioma. Epidemiology suggested an environmental contamination by amphibole fibres rather than risks related to a specific occupational activity. The aim of this study is to describe the diffusion of fibrous amphiboles in the area and identify their source. Fibrous amphiboles were found in the products from the local quarries, which had been used for years to build houses. After sampling all around Biancavilla, three sites were detected and they were characterized by an abundant presence of mineral fibres. Fibrous amphiboles were also recovered from building materials (mortar and plasters) and airborne particulates sampled in urban sites with high dust emissions due mainly to unpaved roads. Moreover, amphibole fibres were detected in the lung tissue of a woman who died of pleural mesothelioma. The results of this study suggest that the amphibole fibre diffusion in the Biancavilla environment lasted for many years and had been maximum during the sixties and the seventies with the uncontrolled development of the local building industry. Today, the environmental situation results to be changed following both the closing of the stone quarries and the urbanization works after 2001, above all the asphalting of dusty roads. Anyway sporadic mesothelioma cases have still to be expected in the next years.

• Trees as reservoirs for amphibole fibers in Libby, Montana. T.J. Ward, T. Spear, J. Hart, et al. 2006;367(1):460-5. PubMed · Publisher

  Abstract

  Tree bark and core samples were collected from areas surrounding the asbestos-contaminated vermiculite mine in Libby, MT. These samples were collected to provide preliminary data in support of a proposed study to determine if trees can serve as reservoirs for amphibole fibers and to determine if there is a potential for exposure to those that harvest contaminated wood in the Libby mine area, specifically during firewood harvesting and commercial logging. Initially, three sets of samples were taken both within and directly outside of the EPA restricted area surrounding the mine site. Based on the results of the initial samples, a follow-up sampling program was conducted both in the town of Libby and directly outside the city limits. Gravimetric reduction of a tree core sample did not indicate the presence of amphibole fibers. However, transmission electron microscopy analysis of bark samples collected near the vermiculite mine yielded substantial amphibole fiber concentrations ranging from 41 million to 530 million fibers/g of bark. In addition, a bark sample collected approximately 7 miles west of the town next to a railroad line had concentrations of 19 million fibers/g. A conversion of these mass-based concentrations to areal concentrations (to reflect surface area contamination) revealed concentrations in excess of 100 million amphibole fibers/cm(2). These preliminary results suggest that trees in the Libby valley and along vermiculite shipping corridors can serve as reservoirs for amphibole fibers, and that a potential for exposure exists for those who harvest contaminated wood.

• Pulmonary fibre burden in sheep living in the Biancavilla area (Sicily): preliminary results. P. DeNardo, B. Bruni, L. Paoletti, et al. 2004;325(1-3):51-8. PubMed · Publisher

  Abstract

  In a national survey on mortality from malignant pleural neoplasms in Italy, aimed at detecting geographic clusters of cases of the disease, the town of Biancavilla, located in a volcanic area of Eastern Sicily, showed high risk of pleural mesothelioma in the absence of occupational asbestos exposure. An environmental survey suggested the stone quarries located in 'Monte Calvario', south-east of the town of Biancavilla, as a possible source of asbestiform fibre exposure. A subsequent crystal-chemistry investigation of the 'Monte Calvario' amphiboles identified the mineral asbestiform fibres as 'fluoro-edenite', a new end-member of the edenite ==> fluoro-edenite series. A collaborative epidemiological and environmental study was initiated to investigate the characteristics of the outbreak of malignant mesothelioma and test the hypothesis of a causal association with exposure to naturally occurring fibres. To investigate if a sheep population could be used to monitor the environmental diffusion of the fibres, we examined lung specimens from 27 culled sheep, at least 3 years old and living near Monte Calvario to check for the presence of fluoro-edenite fibres, using scanning electron microscopy (SEM) analysis and X-ray microanalysis. Fourteen mineral species have been isolated in the mineral particulate matter taken from pulmonary parenchyma, and fluoro-edenite was detected in eight sheep. These preliminary data suggest a possible bio-indicative role of sheep as sentinel animals in the evaluation of environmental fibre diffusion, which merits further investigation.

  Copryright 2003 Elsevier B.V.

• Asbestos: old foe in 21st century developing countries. L.V. Harris, I.A. Kahwa. 2003;307(1-3):1-9. Editorial PubMed · Publisher

  Abstract

  While use of asbestos materials in developed nations has been decreasing because of the harmful health effects of asbestos dust mining, processing and use of the ancient material in developing countries is increasing. The regulatory mechanism for use, handling and disposal of asbestos and associated waste in developing countries are weak and information on asbestos-related diseases is scanty but emerging. We identify lack of epidemiological data on asbestos health effects as a major gap to be bridged in the promotion of occupational and environmental health in developing countries. Without data on local situations, diseases such as asbestosis and mesothelioma remain too obscure to assist the campaign for appropriate regulation of asbestos usage or attracting attention to abominable industrial practices generally.

• Pet dogs as sentinels for environmental contamination. L.C. Backer, C.B. Grindem, W.T. Corbett, et al. 2001;274(1-3):161-9. PubMed · Publisher

  Abstract

  The presence of environmental contaminants in air, water and food may pose significant health risks to the exposed human population. However, problems associated with assessing chronic exposure to low doses of environmental chemicals, multiple exposure routes, diseases with long latency periods, and non-specific health outcomes make it difficult to conduct the appropriate human epidemiologic studies. It may be useful to complement human epidemiology with animal studies. Animals monitored or evaluated in situ for the appropriate suite of endpoints can provide information about both exposure levels and potential adverse health effects. Animals have served as sentinel indicators for health effects associated with a number of environmental exposures, including pesticides and asbestos. Pet dogs may be particularly valuable sentinels because they share the human environment. In addition, dogs respond to many toxic insults in ways analogous to humans, they have physiologically compressed life spans, and they are free from some important lifestyle risk factors for disease. An example of how pet dogs may be used as sentinels for potential human health hazards involves a study of the genotoxic effects resulting from exposure to a mixture of chemicals from nearby Superfund sites. We conducted a cross-sectional study of exposed dogs (living in the community with the Superfund sites) and controls (living in a nearby community). The pet owners completed a questionnaire, and we collected a blood sample from each dog. The blood samples were analyzed for standard clinical parameters and assays for possible genotoxic effects (peripheral blood lymphocyte micronucleus frequency and lymphocyte subtyping). Pet dogs living near the Superfund sites had a higher micronucleus frequency than control animals, suggesting that the dogs may have been exposed to environmental contaminants from these sites.

• The role of metals in autoimmune vasculitis: epidemiological and pathogenic study. P. Stratta, A. Messuerotti, C. Canavese, et al. 2001;270(1-3):179-90. PubMed · Publisher

  Abstract

  Background: A possible relationship between Silica (Si) exposure and antineutrophil cytoplasm antibodies (ANCA)-associated vasculitis has been reported. Furthermore, tuberculosis (TBC) has been frequently described in patients with silicosis, and TBC infection shares with ANCA-associated vasculitis the formation of granulomas. Therefore, an intriguing network including Silica, Vasculitis, TBC and ANCA might be hypothesized. The aim of this work was to further investigate these correlations using both epidemiological and pathogenic approaches.

  Methods: Study I--epidemiological study. A case-control study to compare the occupational histories of 31 cases of biopsy proven vasculitis (18 pauci-immune crescentic glomerulonephritis, 9 microscopic polyangitis, 4 Wegener's granulomatosis) with those of 58 age, sex and residence-matched controls (affected by other kidney diseases), was performed. Occupational Health physicians designed an appropriate questionnaire in order to evaluate a wide spread of exposures and calculate their entity by the product of Intensity x Frequency x Duration. Study II--tuberculosis association. A case-control study to evaluate the frequency of a previous history of tuberculosis (TBC) in 45 patients with vasculitis and 45 controls were performed. Study III--ANCA positivity. A case-control study to evaluate the presence of ANCA was performed by testing blood samples of 64 people with previous professional exposure and 65 sex/age matched patients hospitalized in a General Medicine Unit. Furthermore, the same evaluation was made in a pilot study in 16 patients with ongoing or previous TBC. Study IV--experimental study. The oxygen free radicals (OFR) and IL-12 production (both involved in the pathogenesis of vasculitis) from human phagocytic cells stimulated with an amorphous (diatomaceous earth) and a crystalline (quartz) form of Si at the doses of 10 and 100 microg ml(-1) was evaluated.

  Results: Study I--a positive history of exposure to Si resulted in significantly more present in cases (14/31 = 45%) than in controls (14/58 = 24%, P = 0.04, OR = 2.4) and no other significant exposure association was found (including asbestos, mineral oil, formaldehyde, diesel and welding fumes, grain and wood dust, leather, solvents, fungicides, bitumen, lead and paint). Study II--past TBC infection was significantly more present in patients with vasculitis (12/45 = 26%) than in controls (4/45 = 8%, P < 0.05). Study III--ANCA was present in 2/64 exposed people (vs. 0/65 controls, P = NS) and 0/16 patients with TBC. Study IV--both amorphous and crystalline Si forms represented a stimulus for OFR and IL-12 production, but quartz resulted as a greater inductor.

  Conclusions: We conclude that Si exposure might be a risk factor for ANCA-associated vasculitis, possibly enhancing endothelial damage by phagocyte generation of oxygen free radicals and Th1 differentiation by an excessive IL-12 phagocyte production. Frequency of TBC was significantly higher in vasculitis patients. ANCA was not frequent in the preliminary examination of people with previous professional exposure or patients with TBC, but the number of samples evaluated is too small to allow conclusions.

1990s

• A study of fibrous aerosols in the home environment in Sosnowiec, Poland. J.S. Pastuszka, A. Kabala-Dzik, K.T. Paw. 1999;229(1-2):131-6. PubMed · Publisher

  Abstract

  This work constitutes the first report on the concentration of airborne respirable fibers, and their length distribution in different groups of homes in Sosnowiec, Poland. The measurements have been made by using the MIE Laser Fiber Monitor FM-7400. Mean concentration level of the respirable fibers, longer than 5 microns, ranged from 350 m-3 through 910 m-3 up to 1020 m-3 in the homes located in suburban areas, near the busy streets, and in the buildings covered with asbestos-cement sheets, respectively. These results indicate the outdoor asbestos-containing materials as the main sources of airborne fibers inside the Sosnowiec dwellings.

• Heavy metals in soils and plants of serpentine and industrial sites of Albania. S. Shallari, C. Schwartz, A. Hasko, et al. 1998;209(2-3):133-42. PubMed

  Abstract

  Soils developed on serpentine rocks cover a large area in Albania which contains large reserves of iron, nickel, chromium and copper and is characterised by a high density of mines and metal smelters. This work was conducted to study the flora associated with serpentine and former industrial and mining sites in Albania. Eight sites were investigated in the south-eastern, central and northern parts of the country. Soils were sampled in the Ap horizon and plants were collected and identified. Plant material was allowed to dry before being ground. Soil and plant samples were analysed for total Ca, Cd, Co, Cr, Cu, Mg, Ni, Pb and Zn. Results showed that each site exhibited a high concentration of one or more metals. The maximum concentrations of metals in soils dry matter (DM) were 14 mg Cd kg-1, 476 mg Co kg-1, 3865 mg Cr kg-1, 1107 mg Cu kg-1, 3579 mg Ni kg-1, 172 mg Pb kg-1 and 2495 mg Zn kg-1. The Mg/Ca ratio in serpentine soils varied from 1 to 7.8. A collection of 58 plant species, members of 44 genera and 17 families, were collected. Alyssum markgrafii in the north and Alyssum murale in the south-eastern serpentines had a concentration of 1.26 and 0.85% Ni in DM, respectively. In the species Herniaria hirsuta, a serpentine plant, concentrations of 808 mg Ni kg-1 and 275 mg Cr kg-1 in DM were recorded. Other taxa (Filago, Inula, Picris, Galamintha, Marrubium, Teucrium, Lotus, Ononis and Xeranthemum) from serpentines had a high, but not exceptional Ni content. Some species collected on serpentines and industrial sites presented rather high concentrations of lead or copper in their above-ground parts, probably related to contamination by soil dust.

• Angular and fibrous particles in lung are markers of job categories. A. Dufresne, R. Bégin, C. Dion, et al. 1997;206(2-3):127-36. PubMed

  Abstract

  Introduction: The lung concentration of angular and fibrous particles has been measured when cases are stratified into their job categories; 21 miners (metallic mines such as gold, zinc and copper), 18 iron foundrymen, 22 non-iron foundrymen, four welders, three sand-blast workers, four construction workers, three technicians and professionals, seven workers in other trades excluding welding. Twelve asbestos miners representing a positive exposure to asbestos and 20 people representing a background population were added to the previous groups.

  Material And Methods: Particles, both angular and fibrous, were extracted from lung parenchyma by a bleach digestion method, mounted on copper microscopic grids by a carbon replica technique and analyzed by transmission electron microscopy (TEM) and energy dispersive spectroscopy (EDS). Quartz concentration was also determined by X-ray diffraction (XRD) on a silver membrane filter after the extraction from the lung parenchyma.

  Results: (1) The highest concentrations of quartz were found in mines (metallic mines), iron foundrymen and sand-blast workers. Notable amounts quartz were found in welders and professionals. (2) The highest concentrations of short fibres were found in non-iron foundrymen, asbestos miners and construction workers. (3) The highest concentrations of long fibres were found in non-iron foundry men and asbestos miners. (4) The highest concentrations of ferruginous bodies were found in non-iron foundrymen and asbestos miners. (5) The non-iron foundrymen were exposed to ceramic fibres and asbestos fibres.

  Conclusion: The results of the study may not be representative of the broad spectrum of workers in the industrial activities in which they have been involved. However, the detailed composition of the retained particles of our workers is explained both qualitatively and quantitatively by their work histories. Finally, the broad range of particle types identified in the lungs of these workers illustrate the complexity or trying to determine disease origins in these occupational settings.

• Quantifying health effects from the combined action of low-level radiation and other environmental agents: can new approaches solve the enigma?. W. Burkart, G.L. Finch, T. Jung. 1997;205(1):51-70. Review PubMed · Publisher

  Abstract

  Efforts to assess the quantify deleterious effects from toxicants are directed mainly towards single agents, whereas real world environmental and occupational exposures to natural and anthropogenic agents quite often entail the concomitant presence of several toxicants. These combined exposures may lead to health risks that differ from those expected from simple addition of the individual risks. For example, combined exposures to physical and chemical agents such as radon and smoking or asbestos and smoking produce over-additive effects at exposure levels typical for earlier workplaces. In tumour therapy, the modulation of radiation effects by cytotoxic drugs is widely used to enhance the therapeutic gain. Whether interactions occurring at high exposure levels are important at the low exposure levels set for the public and for modern workplaces is difficult to answer. A scientifically sound extrapolation from these high to low-dose levels should be based on dose-effect relationships of the relevant agents alone and in combination. In general this information is not available. The existing data base on combined effects is rudimentary, mainly descriptive and rarely covers exposure ranges large enough to make direct inferences to present day low-dose exposure situations. In view of the multitude of possible interactions between the large number of potentially harmful agents in the human environment, descriptive approaches will have to be supplemented by the use of mechanistic models for critical health endpoints such as cancer. To generalise and predict the outcome of combined exposures, agents will have to be grouped depending on their physical or chemical mode of action on the molecular and cellular level. Such a grouping must be guided by specific mechanistic studies designed to examine the underlying hypothesis regarding how various classes of agents interact.

• Nickel-related cancer in welders. S. Langård. 1994;148(2-3):303-9. Review PubMed · Publisher

  Abstract

  During stainless steel (SS) welding, solid aerosols are generated from elemental compounds which are generally considered to be human carcinogens; i.e. compounds of hexavalent chromium (CrVI) and nickel. Epidemiological studies among groups of SS-welders have indicated that they may carry a higher risk of acquiring lung cancer than mild steel (MS) welders using the same welding techniques. This excess risk has been demonstrated in cohort as well as by case-control studies. The present evidence does not support the view that exposure to SS-welding fumes poses a hazard of cancer at any other site. Exposure to asbestos and smoking are generally major confounders in these studies. The number of SS-welders world-wide seems to be increasing, thus these findings may be of significance to SS-welders and to the welding industry. Despite the information on the possible cancer hazard among SS-welders, current epidemiological data on cancer incidence and mortality do not offer clear evidence to determine whether exposure to nickel or CrVI compounds constitutes the more important risk factor for lung cancer.

• Guadalupe corridor transportation project asbestos health risk assessment, San Jose, California. W.E. Steiner, J.L. Koehler, W.W. Popenuck. 1990;93:115-24. PubMed · Publisher

  Abstract

  A study was conducted to assess health risks and identify a set of appropriate mitigation measures to control airborne emissions of natural asbestos from construction of the Guadalupe Corridor Transportation Project, a highway and light-rail construction project in San Jose, California. This study supported a state-mandated Environmental Impact Report. Communication Hill, along the project route, is known to contain natural chrysotile asbestos-bearing rock. The study described in this paper estimated potential asbestos emissions, identified and evaluated mitigation measures, and evaluated air pathway exposure and health risks. With mitigation, estimated risks were found to be acceptable by the regulatory agency, and construction proceeded.

1980s

• Natural fibrous zeolites and their carcinogenicity-a review. K.R. Spurny. 1983;30:147-66. PubMed · Publisher

  Abstract

  More than 50 cases of pleural mesothelioma have been reported during the period 1974-1978 in a relatively small area of Turkey, centered in and around the villages of Karain and Tuzköy, in the province of Cappadocia. The area of Karain and Tuzköy is covered with volcanic tuffs, in which asbestos, glass and zeolite fibers were detected. The inhaled dusts of these fibrous materials might be the cause of the high mesothelioma rate. The most important publications on this problem are reviewed and the results of our own examinations are discussed.

• Asbestos and drinking water in Canada. P. Toft, D. Wigle, J.C. Meranger, et al. 1981;18:77-89. PubMed · Publisher

  Abstract

  Samples of raw, treated and distributed tap water were collected from 71 municipalities across Canada and analyzed for asbestos content by transmission electron microscopy. Chrysotile asbestos was identified as the major asbestos type present in drinking water with some 5% of public water supplies containing asbestos at concentrations greater than 10 million fibres per litre. Improvement factors of up to 300 were observed for the removal of chrysotile fibres from drinking water during treatment, indicating that coagulation/filtration treatment is efficient for this purpose. In certain cases there is evidence to suggest that erosion of asbestos from pipe material is taking place. Age-standardized mortality rates for gastro-intestinal cancers were calculated for each city for the period of 1966 to 1976. Rates for the 2 localities with the highest (congruent to 10(8)/L) concentrations of asbestos fibres in treated drinking water were compared with the weighted average of the rates for the 52 localities with asbestos concentrations not significantly greater than zero. Eleven localities had intermediate concentrations of asbestos and six were too small for meaningful statistical analysis. Relatively high mortality rates were apparent amongst males in city 1 for cancer of the large intestine except rectum, and in both sexes in city 1 and males in city 2 for stomach cancer. It is felt that these findings are probably related to occupational exposure to asbestos. Further statistical analyses are required, however, before the significance of these observations can be fully assessed.

• The control of potential health risks related to drinking water in the UK. T.A. Dick. 1981;18:317-34. PubMed · Publisher

  Abstract

  In the United Kingdom, potable water put into supply is required to be 'wholesome'. The term 'wholesome' is interpreted as clear, palatable and safe to drink. About 99% of potable supplies are provided by Regional Water Authorities and Water Companies (for England and Wales), Regional Councils and Island Councils (for Scotland) and the Department of the Environment (NI) (for Northern Ireland). These water authorities draw their raw water from upland surface waters, lowland surface waters (including lakes and rivers) and underground waters. Although each source provides approximately one-third of supply, the proportion varies considerably in different parts of the UK. Consequently the control of potential health risks related to drinking water also varies according to the source of supply. The paper describes briefly the treatment practice for the various sources, including disinfection practice. More specifically the paper describes current UK practice or developments in the control or investigation of plumbosolvency, fluoridation, nitrate, trihalomethanes, other organic micropollutants, sodium, asbestos and tar linings in pipes. The possibilities for the surveillance of the 1% of private supplies are also discussed.

• The need to control asbestos fibers in potable water supply systems. J.R. Millette, R.L. Boone, M.T. Rosenthal, et al. 1981;18:91-102. PubMed · Publisher

  Abstract

  Occupational studies have shown that asbestos is a human carcinogen. Because many inhaled asbestos fibers deposited in the lung are cleared and swallowed, workers are also exposed through ingestion. Of the millions of current and former workers who have been heavily exposed to asbestos, one in ten will die from cancer of the gastrointestinal tract. A number on the order of 1 in 1,000 ingested asbestos fibers penetrate the digestive tract and ingested fibers have been recovered in such tissues as kidney, intestine, liver, and urine. One animal study showed tumor production related to ingestion of asbestos-containing material but, in general, the results of seven animal feeding studies have been inconclusive. A statistically significant relationship between male lung and stomach cancer and female peritoneal, gall bladder, and esophageal cancer and asbestos counts in drinking water was determined in one epidemiology study. Increased rates for male stomach and lung, and female pancreatic cancer related to asbestos in drinking water were reported in another study but possible occupational exposure made it difficult to draw conclusions. Data on excess gastrointestinal cancer among occupational groups has been used to estimate that drinking water containing 300,000 asbestos fibers per liter over a lifetime will result in one additional cancer among 100,000 people.

• Water supply and health, balancing between questions and answers. B.C. Zoeteman. 1981;18:369-74. PubMed · Publisher

1970s

• The organic content of international reference samples of asbestos. J. Hilborn, R.S. Thomas, R.C. Lao. 1974;3(2):129-40. PubMed · Publisher

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