CA: A Cancer Journal for Clinicians

Our medical research library holds 9 studies published in CA: A Cancer Journal for Clinicians (1978–2019). Each entry links to the study's record on PubMed and, where there is one, to the publisher's page and a free full text. 5 have an abstract, the authors' own summary as PubMed records it: open "Abstract" to read it.

About the journal

• Publisher: Wiley
• Published: 1950 to the present, United States
• Language: English
• ISSN: 0007-9235 (print), 1542-4863 (electronic)
• Its record in the NLM Catalog

2010s

• Mesothelioma: Scientific clues for prevention, diagnosis, and therapy. M. Carbone, P.S. Adusumilli, H.R. Alexander, et al. 2019;69(5):402-429. Review PubMed · Publisher · Free full text

  Abstract

  Mesothelioma affects mostly older individuals who have been occupationally exposed to asbestos. The global mesothelioma incidence and mortality rates are unknown, because data are not available from developing countries that continue to use large amounts of asbestos. The incidence rate of mesothelioma has decreased in Australia, the United States, and Western Europe, where the use of asbestos was banned or strictly regulated in the 1970s and 1980s, demonstrating the value of these preventive measures. However, in these same countries, the overall number of deaths from mesothelioma has not decreased as the size of the population and the percentage of old people have increased. Moreover, hotspots of mesothelioma may occur when carcinogenic fibers that are present in the environment are disturbed as rural areas are being developed. Novel immunohistochemical and molecular markers have improved the accuracy of diagnosis; however, about 14% (high-resource countries) to 50% (developing countries) of mesothelioma diagnoses are incorrect, resulting in inadequate treatment and complicating epidemiological studies. The discovery that germline BRCA1-asssociated protein 1 (BAP1) mutations cause mesothelioma and other cancers (BAP1 cancer syndrome) elucidated some of the key pathogenic mechanisms, and treatments targeting these molecular mechanisms and/or modulating the immune response are being tested. The role of surgery in pleural mesothelioma is controversial as it is difficult to predict who will benefit from aggressive management, even when local therapies are added to existing or novel systemic treatments. Treatment outcomes are improving, however, for peritoneal mesothelioma. Multidisciplinary international collaboration will be necessary to improve prevention, early detection, and treatment.

  © 2019 American Cancer Society.

• Local Cancer Recurrence: The Realities, Challenges, and Opportunities for New Therapies. D.A. Mahvi, R. Liu, M.W. Grinstaff, et al. 2018;68(6):488-505. Review PubMed · Publisher · Free full text

  Abstract

  Locoregional recurrence negatively impacts both long-term survival and quality of life for several malignancies. For appropriate-risk patients with an isolated, resectable, local recurrence, surgery represents the only potentially curative therapy. However, oncologic outcomes remain inferior for patients with locally recurrent disease even after macroscopically complete resection. Unfortunately, these operations are often extensive, with significant perioperative morbidity and mortality. This review highlights selected malignancies (mesothelioma, sarcoma, lung cancer, breast cancer, rectal cancer, and peritoneal surface malignancies) in which surgical resection is a key treatment modality and local recurrence plays a significant role in overall oncologic outcome with regard to survival and quality of life. For each type of cancer, the current, state-of-the-art treatment strategies and their outcomes are assessed. The need for additional therapeutic options is presented given the limitations of the current standard therapies. New and emerging treatment modalities, including polymer films and nanoparticles, are highlighted as potential future solutions for both prevention and treatment of locally recurrent cancers. Finally, the authors identify additional clinical and research opportunities and propose future research strategies based on the various patterns of local recurrence among the different cancers.

  © 2018 American Cancer Society.

1990s

• Asbestos-related cancer. J.F. Genits. 1996;46(4):254-5. Comment · Letter PubMed · Publisher
• Carcinogens and the workplace. R. Hawkins. 1996;46(4):255-6. Comment · Letter PubMed · Publisher

1980s

• Ovarian cancer. H.R. Barber. 1986;36(3):149-84. Review PubMed · Publisher

  Abstract

  Early diagnosis is the most effective means of reducing the currently high mortality rate associated with ovarian cancer. The palpation of what appears to be a normal size ovary in a premenopausal woman suggests an ovarian tumor in a postmenopausal woman. Ovarian cancer should be ruled out in any woman 40 years of age or older who has persistent, unexplained GI symptoms. Ninety percent of all ovarian tumors are of epithelial origin. Treatment consists of total hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and appendectomy. Instillation of P32 is optional. In stages IIb, III, and IV tumors, chemotherapy is advised; in stages I and IIa, the use of prophylactic chemotherapy must be judged on an individual basis. In children, ovarian cancer that is beyond the localized stage is one of the most frustrating of all gynecologic diseases. Total surgical extirpation of disease is the only hope for cure; for now, early diagnosis is more chance than scientific method. Thanks to better public and professional education, ovarian cancer is now being diagnosed at an earlier stage. The earlier the diagnosis, the greater the chance for cure. It is becoming obvious that ovarian cancer is a disease of the GI tract, and physicians treating ovarian cancer should be prepared to deal with bowel-associated problems. The practice of tapping women with ascites for diagnosis as well as doing an exploration merely to obtain a biopsy should be discouraged. Unless the physician is prepared to carry out the optimal surgical approach for the patient, it is crucial that the patient be referred to either a center or to a physician who is actively engaged in the day-to-day care of cancer patients. With the combined use of all the available treatment methods, patients with ovarian cancer are now living longer and more comfortably. There is also indication that their long-term survival will be increased. The one message that is important for both patients and physicians is that the gloom and doom of the 1960s and 1970s can now be replaced by a spirit of optimism.

• Asbestos: historical perspective. L. Garfinkel. 1984;34(1):44-7. Historical article PubMed · Publisher

• Classics in Oncology: Asbestos exposure and neoplasia. I.J. Selikoff, J. Churg, E.C. Hammond. 1984;34(1):48-56. Historical article PubMed · Publisher

  Abstract

  Building trades insulation workers have relatively light, intermittent exposure to asbestos. Of 632 insulation workers, who entered the trade before 1943 and were traced through 1962, 45 died of cancer of the lung or pleura, whereas only 6.6 such deaths were expected. Three of the pleural tumors were mesotheliomas; there was also one peritoneal mesothelioma. Four mesotheliomas in a total of 255 deaths is an exceedingly high incidence for such a rare tumor. In addition, an unexpectedly large number of men died of cancer of the stomach, colon, or rectum (29 compared with 9.4 expected). Other cancers were not increased; 20.5 were expected, and 21 occurred. Twelve men died of asbestosis.

• Granulocytic sarcoma of the peritoneum. T. Miksanek, C.V. Reyes, Z. Semkiw, et al. 1983;33(1):40-3. Case report PubMed · Publisher

  Abstract

  Granulocytic sarcoma is an unusual extramedullary tumor composed of immature cells of the myelogenous series; it usually occurs during the course of myelogenous leukemia. This paper presents a rare case of granulocytic sarcoma of the peritoneum, occurring without evidence of myelogenous leukemia in peripheral blood and bone marrow.

1970s

• Asbestos-associated disease in United States shipyards. I.J. Selikoff, E.C. Hammond. 1978;28(2):87-99. PubMed · Publisher

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